Biomedical subjects
Publications and source records attributed to J F Hamon.
Ten young men underwent a sleep deprivation of 48 h which resulted in a 19 percent decrease of beard-hair growth. This effect, reflecting the lowering of protein synthesis during sleep deprivation, was presumably related to hormonal disturbance, namely depression of growth hormone release, decrease of dihydroxytestosterone availability or increase of sympathetic tone and/or corticoids.
The aim of this research was to study brain information processing during waking, deep slow sleep (stage IV) and paradoxical sleep (stage V) in humans, by using as a clue endogenous components of the sensory evoked potential, the emitted potential and the contingent negative variation (CNV). Eight subjects underwent three kinds of mixed auditory stimulus couples: (a) SI-SII: 2 identical clicks (50 msec, 5000 Hz); (b) SI-SIII: SIII (50 msec, 500 Hz) different from SI, was during waking, the target stimulus; (c) SI followed by an omitted click. During sleeping, the situation was used without motor response. The contingent negative variation was clearly observed during waking and paradoxical sleep as the evoked potential whose morphology during deep slow sleep was similar to K complexes. The emitted potential was obtained in four subjects out of seven during paradoxical sleep. These results suggest that during wakefulness, the discrimination of an unconditional stimulus involves a conditioning establishment revealed by the CNV and the emitted potential. The fact that the emitted potential and CNV were unavailable during stage IV is an argument in favor of the hypothesis that the conditioning effects disappear during deep slow sleep. The occurrence of CNV and emitted potential during the paradoxical stage of sleep, suggests that a conditioning established during waking can appear during this stage of sleep.
The aim of the study was to assess the effects of chronic palm alcohol (a compound of ethyl and methyl alcohols distilled from palm tree wine) consumption, on waking electroencephalogram (EEG) of 60 alcoholics of both sexes. Four profiles have been determined on EEG abnormalities criteria: 1/ theta rhythms (44 patients), 2/ slow alpha rhythms (9 patients), 3/ slow waves and 4/ paroxysmal rhythms. The whole results are globally in agreement with reports regarding waking EEG abnormalities in ethylic subjects. Nevertheless the presence of thêta waves in recordings of many of the subjects, all irritable or aggressive and exhibiting emotional disturbances, would constitute the sign of this alcoholic type.
One hundred and two patients with Crohn's colitis present on average for 8 years, were studied retrospectively in order to determine whether or not a group of patients existed in whom the disease remained limited to the colon, and if such a group could be identified early on in the course of the disorder. At the time of the diagnosis of Crohn's disease, 34 patients had a concomitant anoperineal lesion, while 68 had disease affecting the colon only. In the latter, at the end of the follow-up period, the disease remained exclusively limited to the colon in 39 cases (57 p. cent). The actuarial rate of non-extra-colonic spread was 75, 40 and 35 p. cent at 5, 10 and 15 years respectively. Spread involved above all the anoperineal region (55 p. cent at 10 years), and less often the ileum (20 p. cent at 10 years). In patients monitored for at least 6 years, there was no significant difference between those in whom disease had spread and those in whom it remained limited to the colon, regarding the main initial clinical findings by history and examination, the same applying after the disease had been present for 3 years. These results would go against the existence of a specific entity of "Crohn's disease affecting the colon as an organ" and support the opinion that coloproctectomy with a pouch should be avoided in colitis due to Crohn's disease.
OBJECTIVES: To evaluate the influence of the indication of the first surgical procedure on the prognosis of Crohn's disease. METHODS: We compared retrospectively the long-term course of 179 patients operated on for a perforating disease and 322 patients operated on for a nonperforating disease. Mean follow-up was 11 years and 2 months in the two groups. RESULTS: Forty of 179 (25%) and 106 of 322 (33%) patients with perforating and nonperforating diseases underwent a second intestinal resection, respectively. The patients who had been operated on for a perforating disease were significantly more often reoperated on for the same indication, and conversely. Patients with perforating diseases experienced less second resections (actuarial rates: 37 +/- 11% vs 51 +/- 8% at ten years respectively), less post-surgical handicaps (mean index 24.9 vs 27.9), and fewer patients required immunosuppressive drugs (25 vs 35%). CONCLUSION: Long-term prognosis of perforating Crohn's disease does not appear to be more severe than that of nonperforating disease.