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Biomedical subjects

J Freitag

Publications and source records attributed to J Freitag.

At least 73 records · Page 4Linked to original sources
PubMed1982

[Quantitative determination of regional cerebral circulation with Xe-133: lst experiences using this method in the clinic].

After injection of the radioactive noble gas Xe133 into the A. carotis interna, the regional blood flow in the brain is determined with a 10-channel measuring unit. From the first clinical evaluation of the findings in 35 patients, the following conclusions can be drawn: 1. In epileptics, a localised hyperaemia very probary indicates a latent increased convulsive activity. 2. The measurement of the cerebral blood flow does not yield a contribution to the diagnosis of the type of cerebral tumours. 3. As a consequence of mass shifting of space occupying processes particularly endangered brain sections, also remote from the focus proper, show a localised pathological hyperaemia (morbid "luxus perfusion"). 4. Of greatest importance is the method for clearing up of pathophysiological relations, the clearing up of questions in connection with the blood/brain barrier function, and for the indications for and estimation of the results of vascular-surgical interventions.

Brain↗
PubMed1982

[Results of computer tomographic diagnosis of the kidney].

The diagnostic value of CT scanning in kidney diseases was checked on the basis of a retrospective evaluation of the findings of 400 examinations. The significance of expansive processes could be established, with the exception of a blood-filled cyst, which was classified as malign. Even in cases of urinary stasis and unilateral renal non-functioning a comprehensive clarification of the pathological finding was possible.

Abscess↗
PubMed1981

The arterio-venous difference for immunoreactive parathyroid hormone and the production of adenosine 3,'5'-monophosphate by isolated perfused bone: studies with analogs of parathyroid hormone.

Recent studies suggest that the uptake of immunoreactive parathyroid hormone (iPTH) displays different characteristics in liver, kidney, and bone. Using the isolated perfused canine bone, we have characterized the uptake of two synthetic analogs of PTH, bovine PTH-(3-34) [bPTH-3(3-34)] and [Nle8,Nle18,Tyr34]bPTH-(3-34) amide, which had previously been shown to inhibit PTH-stimulated adenylate cyclase activity in renal membranes. During the infusion of synthetic bPTH-(1-34) (3 ng/ml), extraction of iPTH by isolated perfused bone averaged 37 +/- 1%, and cAMP production rose from 6.2 +/- 2.0 to 21 +/- 3 pmol/min. Extraction of bPTH-(3-34) was similar (35 +/- 2%), but cAMP levels did not increase over baseline with PTH concentrations as high as 100 ng/ml. Simultaneous infusion of bPTH-(1-34) and bPTH-(3-34) at molar ratios of 1:2 led to a 50% inhibition of PTH-stimulated cAMP increases. The extraction by bone of the more potent in vitro inhibitor of renal cortical adenylate cyclase [Nle8,Nle18,Tyr34]bPTH-(3-34) NH2 (3 ng/ml) averaged 39 +/- 2%. In contrast, cAMP production rose from a baseline of 5.6 +/- 0.5 to 12.5 +/- 2.0 pmol/min, demonstrating agonist activity for the analog. These studies show that [Nle3,Nle18,Tyr34]bPTH-(3-34) NH2 has agonist properties in isolated perfused bone, and unsubstituted bPTh-(3-34) inhibits PTH-stimulated cAMP release by perfused bone.

Animals↗
PubMed1981

[The results of reno-vasography in the diagnosis of space-occupying processes].

In the great majority of cases the renovasography allows clear evidence concerning the dignity of a growing and displacing process. In 362 patients 200 angiographically malignant findings and 174 renovasographically benign processes were found. In 187 cases (93.5%) in malignant findings an accordance with the result of the histological examination could be achieved. In 12 cases falsely negative findings were got. 1 case (0.5%) resulted in falsely positive findings on the opposite side. In 174 circumscribed benign changes of the kidney 164 cases (94%) were judged angiographically correctly. 5 (3%) were not classified exactly. 5 (3%) showed angiographically the picture of the malignant tumour.

Adenocarcinoma↗
PubMed1981

[Diagnosis of brain abscesses by angiography and nuclear medicine methods].

In most cases, abscesses are formed otogenically or rhinogenically. The clinical symptoms may be uncharacteristic. The diagnosis is made by employing nuclear-medical and angiographic procedures. In 40 patients suspected of having a cerebral abscess, transfemoral cerebral angiography and in 14 cases gammaencephalography or cerebral scintigraphy was carried out. Angiographically, cerebral abscesses mostly appear as avascular growths while nuclear-medical or localised increase in the activity concentration suggests a pathological finding. The symptoms are uncharacteristic and can only be attributed to an abscess process in connection with clinical and paraclinical findings.

Adolescent↗
PubMed1981

[Diagnosis of space-occupying processes of the kidney by sequence scintigraphy and renovasography].

Proof and classification of a space-demanding process of the kidney is most successfully done by means of renovasography. The nuclear-medical investigation methods give only unspecific references to the disease. Investigation results of radionephrography, sequence scintigraphy and renovasography of 130 kidneys with space-demanding processes were comparatively evaluated. Renovasographically the findings of 35 malignant tumours, 58 solitary cysts and 37 polycystic degenerations were correctly classified. The radionephrography is of no importance for the diagnostics of space-demanding processes. The results of the sequence scintigraphy were in demands of space localised defects of parenchyma, reductions of parenchyma and one a non-functioning kidney. These findings gave rise to angiographical clarification. In the polycystic degeneration the irregular distribution of the activity in the parenchyma, multiple parenchymal defects and the enlargement of the organ referred to the disease.

Diagnosis, Differential↗
PubMed1981

[Experiences in the determination of brain death].

The experience gained in the ascertainment of the brain death in 45 cases permits to draw the following conclusions: 1. The irreversible functional loss of the brain is in the first place diagnosed on the basis of the clinical-neurological findings. 2. The clinical ascertainment of the brain death requires a considerable amount of experience and should be carried out jointly by neurologists and anaesthesiologists. 3. By using cerebral angiography for proving the arrest of the cerebral circulation it is possible to ascertain the brain death earlier, to cut the pending time and to carry out a possibly envisaged removal of an organ in the period before the dropping of temperature and blood pressure.

Adolescent↗
PubMed1980

The preparation of lipid-free extracts of drugs from blood for gas chromatographic analysis.

A method is presented to separate co-extracted biological materials, in particular lipids, from drugs in chloroform extracts of blood. The chloroform is evaporated and the residue is dissolved in a small volume of petroleum ether and partitioned with eight times this volume of 5% aqueous hydrochloric acid. The acidic, basic, and neutral drugs are extracted into the aqueous phase, leaving unwanted materials in the petroleum ether. The recoveries of drugs representative of a variety of types are presented. Reduction of the levels of lipids by factors on the order of 1000-fold is reported.

Centrifugation↗
PubMed1980

[Value of kidney perfusion scintigraphy in the diagnosis of hypertension].

The investigation findings of radionephrography, sequence scintigraphy and renovasography of 35 patients with hypertension were compared with the results of the renal perfusion scintigraphy. In chronic inflammatory renal diseases, stenoses of the renal arteries and space-occupying processes a good correlation of the findings is the result. The results of the investigations allow of the conclusion that the renal perfusion scintigraphy gives the possibility of a more aimed use of the angiography in the clarification of the renal cause of a hypertension.

Humans↗
PubMed1979

[Experiences with primary and secondary laparotomy with splenectomy in Hodgkin's disease].

The explorative laparotomy with splenectomy belongs under adequately strong indication to the standard techniques of the dilated diagnostics and stage subdivision of lymphogranulomatosis. 61 patients of the Medical Academy Magdeburg were exploratively laparotomised from 1974--1978, of them 38 patients primarily before the beginning of the therapy and 23 patients secondarily 1--8 years after therapy. Changes of the stages before and after laparotomy, relations between affection of the spleen and histological type and primary histology, respectively, as well as weight of the spleen are discussed, postoperative complications are explained and adequate conclusions rendered.

Diagnostic Techniques, Surgical↗
PubMed1979

[Angiographic diagnosis in renal injuries].

Blunt abdominal traumas are frequently connected with renal injuries. Adequate clinical symptoms and changes demonstrated by secretion urography refer to a renal trauma. An exact statement concerning kind, localisation and size of the injury may preoperatively be got only by renovasography. In 37 patients in 17 cases unconspicuous angiographic findings were made. Here superficial ruptures of the parenchyma once escaped demonstration. 6 times up to now unknown preexisting renal diseases without proof of a sequel of traumas were the result. In 2 cases moderately severe and in 3 patients severe renal traumas appeared.

Accidents, Traffic↗