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Biomedical subjects

J Fuchs

Publications and source records attributed to J Fuchs.

At least 145 records · Page 8Linked to original sources
PubMed1984

Plasma viscosity in ischemic heart disease.

Plasma viscosity was measured by the capillary method in 108 patients with ischemic heart disease. The highest value of plasma viscosity was found in 11 patients with severe unstable angina (1.66 +/- 0.068), while in 18 patients with less severe unstable angina plasma viscosity was lower (1.61 +/- 0.056; p less than 0.025). In 43 patients with acute myocardial infarction plasma viscosity was 1.53 +/- 0.10, significantly lower than in the two groups with unstable angina (p less than 0.005). In 36 patients with stable angina plasma viscosity was 1.42 +/- 0.089, similar to that found in 100 normal subjects. Plasma viscosity did not increase in 30 ischemic heart disease patients during exercise-induced myocardial ischemia. It is suggested that the elevated plasma viscosity in unstable angina demonstrated in this study compromises the oxygen delivery to the myocardium and coronary blood flow and therefore may possibly be a factor in the pathophysiology of this syndrome.

Adult↗
PubMed1984

Low serum creatine phosphokinase values in patients with acute viral hepatitis.

Low values of serum creatine phosphokinase (CPK) were found in a group of 27 patients suffering from acute viral hepatitis. The values were significantly lower than CPK values in a group of 25 patients with extra hepatic obstructive jaundice (23.3 +/- 32.1 versus 163 +/- 43 U/L, p less than 0.001). CPK values in the hepatitis group when recovered (6 months after hospitalization) were much higher than the mean CPK levels in the same group during the acute illness (178 +/- 28 versus 23.3 +/- 32.1 U/L, p less than 0.001) and were the same as a control group of 26 healthy volunteers (179 +/- 28 versus 179 +/- 20.9 U/L). Similar results were found when the groups were divided into separate male and female groups. Serum CPK values, thus, were found to be a useful diagnostic tool to distinguish between patients with intrahepatic jaundice due to acute viral hepatitis and patients with extra hepatic obstructive jaundice.

Adolescent↗
PubMed1983

Multiform accelerated idioventricular rhythm in acute myocardial infarction: electrocardiographic characteristics and response to verapamil.

Thirteen patients with acute myocardial infarction with multiform accelerated idioventricular rhythm (AIVR) occurring during the first 12 hours of monitoring in the coronary care unit are described. This arrhythmia, similar to the more common uniform AIVR, was intermittent, did not cause hemodynamic compromise, and was not related to more serious ventricular arrhythmias. There was no correlation between the bundle branch block pattern of the multiform AIVR and the electrocardiographic location of the myocardial infarction, but there was a perfect correlation between the frontal plane electrical axis of the multiform AIVR and the electrocardiographic location of the myocardial infarction. The presence of fusion beats between the different forms of AIVR suggests multifocality rather than multiformity. Intravenous verapamil (3 to 5 mg bolus) was administered to 6 patients with multiform AIVR in whom the arrhythmias were persistent enough to allow the evaluation of the effect of verapamil on the arrhythmia. Verapamil caused no change in the rate of AIVR in 1 patient, but in a second patient it decreased the rate by 20 beats/min. In 4 patients, verapamil abolished the arrhythmia: in 2 patients carotid sinus pressure (induced sinus slowing) allowed the emergence of the AIVR at a lower rate, and in the remaining 2 patients the arrhythmia was not observed.

Adult↗
PubMed1982

Entorhinal cortex lesions induce a decreased calcium transport in hippocampal mitochondria.

Lesions to the entorhinal afferent of the hippocampus in rats caused marked changes in calcium transport into mitochondria. Pyruvate-supported calcium transport into mitochondria from the denervated hippocampus was decreased to a larger extent than succinate-supported transport, and adenosine triphosphate-supported transport was not significantly modified. Although cytochrome oxidase and succinate dehydrogenase activities were not significantly changed by entorhinal lesions, pyruvate flux through pyruvate dehydrogenase was significantly decreased, and this effect was correlated with changes in pyruvate-supported calcium transport. The active portion of pyruvate dehydrogenase decreased, whereas total pyruvate dehydrogenase was not modified. These data suggest that denervation might initiate dendritic atrophy and subsequent growth responses by modifying calcium regulation through a change in the phosphorylation of pyruvate dehydrogenase.

Adenosine Triphosphate↗
PubMed1982

[Diagnosis and therapy of carotid sinus syndrome (author's transl)].

We investigated 76 patients with carotid sinus syndrome followed over a time period of 12-40 months (mean 24 months). In 27 patients long-term ECG were recorded over 24 hours continuously. Carotid Doppler sonography was performed in all patients. 14 patients were studied electrophysiologically. The long-term ECG examinations in patients with carotid sinus syndrome showed a significant tendency to nocturnal bradycardia, and normal heart frequency during the day. In 41% of patients extracranial obstruction of internal carotid arteries could be demonstrated. During carotid sinus massage was a significant increase of the AH time, but there was no significant changes of the HV time. 12 out of 14 patients (86%) developed an AV-block during carotid sinus massage and atrial pacing. In 31 patients pacemakers were implanted. The indication for pacemaker implantation was the clinical symptom of syncope. These patients were observed over a period of 15-40 months (mean 24 months). 15 patients were free of symptoms after the pacemaker implantation, whereas 8 patients complained of dizziness and 4 patients experienced TIA's. 45 patients without pacemaker implantation were observed over a time period of 12-24 months. 30 patients were followed over 12 months. 16 patients were free of symptoms, 14 complained of dizziness. There was no syncopy in this group and no patients died during the observation period. In patients with cardio inhibitory carotid sinus syndrome and syncopy, pacemaker implantation is the therapy of choice. In asymptomatic patients or patients with occasional dizziness pacemaker is not indicated.

Aged↗
PubMed1979

[Conservative management of senile cataract with conjunctisan A eye drops].

It seems to be a generally held view that there is no way of treating senile cataract successfully. However, this view is contradicted by the results of a long-term study carried out on 192 eyes treated with Conjunctisan A. According to these results lens opacities in senile cataract can indeed be influenced by therapy. Conjunctisan is a new therapeutic principle which exploits the effect of watersoluble protoplasmic elements, in particular proteins, ribonucleic and deoxyribonucleic acids, phospholipids, polysaccharides, lens-cell-specific nucleic acids and amino acid precursors from the lens, vitreous body, retina, optic nerve, cornea, conjunctiva and placenta. Over a period of observation of 5 years (1973-1978) Conjunctisan A eye drops were administered to the conjunctival sac twice or three times a day. Out of 192 eyes thus treated, lens opacification was halted in 36% and vision improved in 45%. These results concur with those of our earlier investigations on 74 eyes (1969-1973). It is also worth mentioning that opacification is slowed down much more than previously assumed on the basis of experience: this was demonstrated in a comparison with 75 cases of senile cataract that were not treated or treated only by conventional methods.

Aged↗
PubMed1978

Demonstration of immunoglobulin production by tumor cells in non-Hodgkin's and Hodgkin's malignant lymphomas and its significance for their classification.

Combined application of morphologic, immunochemical, and immunologic methods has led to a reinterpretation of non-Hodgkin's lymphomas and to the establishment of the Kiel classification. In the present paper, the main Ig-producing entities are considered. These are: 1. Chronic lymphocytic leukemia of the B-type (B-CLL)--a proliferation of lymphocytes and a few so-called prolymphocytes and lymphoblasts. The mean tissue IgM value is slightly increased; the serum IgM level is normal or reduced. The tumor cells bear SIg, and a majority of them have a receptor for C3d but always lack CIg and are usually devoid of receptors for C3b. 2. Lymphoplasmacytoid immunocytoma--a mixed proliferation of lymphocytes and centrocytes, blast cells, plasma cells, or plasmacytoid cells. The tissue Ig content is most often (91%) and most highly increased in this group, whereas the serum Ig level is increased in only 20% of the cases. The tissue IgM of 17 cases was shown to be monoclonal by IEF. Most tumor cells have SIg and a variable numbear CIg. The tumor cells bear both complement receptor subtypes, only a receptor for C3b, or no complement receptors at all. 3. Centroblastic/centrocytic lymphoma--usually a follicular proliferation of abundant small germinal center cells (centrocytes) and some large germinal center cells (centroblasts). The tumor cells bear SIg and both complement receptor subtypes. The C3b- and C3d-positive cells are located in the follicles, as in nonneoplastic lymphatic tissue. 4. Centrocytic lymphoma--a purebred, diffuse proliferation of the small germinal center cells (centrocytes). These cells bear SIg and receptors for C3b and C3d but usually lack CIg. 5. Centroblastic lymphoma--a proliferation of the large germinal center cells (centroblasts). 6. Lymphoblastic lymphoma of Burkitt's type. 7. Immunoblastic lymphoma--a diffuse proliferation of large basophillic cells resembling immunoblasts. The tissue IgM content is increased in 60% of the cases. It proved to be monoclonal with IEF in all five cases studied. The cells of five cases with increased tissue Ig content bore SIg. Nearly half of the cases studied showed CIg. Besides non-Hodgkin's lymphomas, paraffin sections of 87 biopsies from Hodgkin's disease were investigated for CIg in Hodgkin's and Sternberg-Reed cells. These cells stained positively in 68 cases, most often for IgG, followed by IgD. In five cases of the lymphocyte-depleted type, the staining of the Hodgkin's and Sternberg-Reed cells was restricted to one light chain type.

Burkitt Lymphoma↗
PubMed1977

Isolation of an Escherichia coli mutant deficient in thioredoxin reductase.

A mutant of Escherichia coli defective in thioredoxin reductase has been isolated and partially characterized. This mutant has no detectable thioredoxin reductase activity in vitro and yet it exhibits no in vivo defect in reduction of ribonucleotides. Evidence is presented that indicates that, in cells permeabilized via ether treatment, ribonucleoside diphosphate reduction can utilize glutathione as an alternate reducing system.

Escherichia coli↗
PubMed1977

[On the clinical picture and therapy of arachnitis optico-chiasmatica (author's transl)].

From 20 cases of arachnitis optico-chiasmatica (a. o.) the symptoms of this relatively rare but pathologico-anatomically proved disuse of the brain base involving the optic nerves are described. In this description newer methods of investigation are mentioned which allow a differentiation of the clinical picture of o.a. from that of tumors of the middle cranial fossa. A single case is described in especial detail because a remarkable corneal cloudiness occured in it. The anatomical connection between this corneal cloudiness and vegetative nerve fibers in the region of the Gasserian ganglion is mentioned in honour of the theory of Speransky on nerve-directed tissue changes.

Aged↗
PubMed1977

[Cytotoxic and antitumor effect of antibiotic PSX-1 in vitro and in vivo].

The inhibitory effect of antibiotic PSX-1 on tumour cells was studied in vitro and in vivo. The antibiotic inhibited above all the utilization of the added 14C-labelled uridine and adenine in EAC cells. After a short exposure to PSX-1 (180 min) the synthesis of nucleic acids and proteins in EAC proliferating in vitro was suppressed. Antibiotic PSX-1 in concentrations of about 2.5 mg/ml showed relatively low toxicity on normal human fibroblasts but caused a marked cytotoxic and cytopathic effect on tumour cells. A potential antitumor effect of PSX-1 was evaluated in vivo by using gradually EAC and L 1210 tumours. All the animals treated with the antibiotic in doses of 2.5--5.0 mg/kg/day with the use of EAC and 5.0 mg/kg/day with the use of L 1210 survived for 90 and 40 days respectively and no tumours developed in the treated mice during this period.

Animals↗