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Biomedical subjects

J Gregor

Publications and source records attributed to J Gregor.

60 records · Page 4Linked to original sources
PubMedDate not supplied

New groups of antimycobacterial agents: 6-chloro-3-phenyl-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones and 6-chloro-3-phenyl-2H-1,3-benzoxazine-2,4(3H)-dithiones.

A series of 6-chloro-3-phenyl-4-thioxo-2H-1,3-benzoxazine-2(3H)-ones 3 and a series of 6-chloro-3-phenyl-2H-1,3-benzoxazine-2, 4(3H)-dithiones 4 were synthesized by melting 6-chloro-3-phenyl-2H-1, 3-benzoxazine-2,4(3H)-dione and its derivatives substituted on the phenyl ring 2 with tetraphosphorus decasulfide. Compounds 2c-e, 3 and 4 exhibited in vitro activity against Mycobacterium tuberculosis, M. kansasii (two strains) and M. avium better than or comparable to that of isoniazid. Replacement of the oxo group by a thioxo group at position 4 led to improvement in activity against M. tuberculosis and M. kansasii. The Free-Wilson method and procedure developed by the authors were used to analyse the structure-activity and structure-antimycobacterial profile relationships, respectively.

Anti-Bacterial Agents↗
PubMedDate not supplied

Evaluation of the endomysial antibody for celiac disease: operating properties and associated cost implications in clinical practice.

OBJECTIVE: To evaluate the operating properties of endomysial antibodies (EMAs) in the diagnosis of celiac disease and to examine, using a cost minimization model, different strategies used in the diagnosis of celiac disease. METHODS: A total of 248 EMA results were reviewed and compared with small bowel biopsy results in 66 patients who had undergone both tests. Regression analysis was used to look for predictors of positive EMA results and positive biopsy results. A cost minimization model from a societal perspective was used to evaluate the cost differences among three different strategies. RESULTS: EMAs had a sensitivity of 95% and specificity of 64%. The only predictor of a positive biopsy result that reached statistical significance was a positive EMA. The strategy of EMA as a diagnostic test for celiac disease was the most expensive strategy, with a cost of $3,174 per patient assessed. The strategy of small bowel biopsy for all patients had a cost of $997, and a strategy of EMA followed by small bowel biopsy for positive patients had a cost of $866 per patient. The results were sensitive to cost of a gluten-free diet, the specificity of the EMA and the cost of a small bowel biopsy. CONCLUSION: The EMA is best used as a screening test from both a clinical and cost perspective.

Adolescent↗
PubMedDate not supplied

[Diagnostic procedure and surgical treatment of lipoblastoma in children. Own experience].

Three cases of surgical treatment of the right supraclavicular fossa lipoblastoma in a 9-year-old boy, the mesentery lipoblastoma in a 13-month-old boy and retroperitoneal space lipoblastoma in a 6-month-old boy are presented. Deformity of supraclavicular fossa in the first patient, abdomen circumference enlargement in the second and right abdomen deformity in the third patient were the only symptoms. The above mentioned symptoms lasted respectively 5, 3 months and 7 days. X-rays and sonography examinations showed the presence of solid capsuled mass of tabular structure each time. CT scans in patient with mesentery lipoblastoma revealed additionally a fat-like tissue of the tumour (CT examination in the third patient gave suspicion of lipopblastoma). All tumours were surgically removed - they had tabular structure and were capsuled. The diameters were respectively: 6.5 x 6x 4 cm, 20 x 16 x 9 cm and 13x16x6 cm. This is to emphasize that the results of preoperative examinations as far as size, borders and tabular character of both tumours were very accurate when compared with intraoperative picture. No postoperative complications were noted. The follow-up recheck period is 2 years in the first, 9 months in the second and I day in the third case. All boys are well.

Child↗