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J Grunt

Publications and source records attributed to J Grunt.

At least 55 records · Page 3Linked to original sources
PubMed1975

Nation-wide survey of antibiotic resistance by means of a computer. Analysis of 200.000 strains of problem bacteria isolated in 1973.

Based on a pilot study performed in 5 District Public Health Laboratories (PHL) in the Slovakia in 1972 (1), the computer system for elaborating the informations concerning the resistance of "problem bacteria" to antibiotics has completely been introduced in 18 PHLs for all-year studies on the resistance to antibiotics in 1973. The results obtained in each PHL and also in total of about 200.000 bacterial strains belonging to 8 of the clinically most important bacterial species were passed on to the corresponding PHL and to the health authorities twice a year. Each PHL elaborated these data being useful and instructive for general practitioners and clinicians in the hospitals of their districts to a commented information on the actual state of effectiveness of individual antibacterial drugs. The multiple spectra of resistance to antibiotics indicating the occurrence of R plasmids in clinical isolates of bacteria and the dynamics for the development of resistance against certain specially monitored "reserved antibiotics" are elaborated at present and will be published in a subsequent communication...

Anti-Bacterial Agents↗
PubMed1975

Nationwide survey of antibiotic resistance by means of a computer. An introduction into the analysis of multiple antibiotic resistance.

One-year surveillance of single and multiple antibiotic resistance of 8 species of so-called "Problem Bacteria" by computer analysis of data obtained from 18 Public Health Laboratories in Slovakia in 1973 enables to establish the most frequently occuring spectra of multiple drug resistance which would point to the spread of typical R plasmids among the Problem bacteria investigated. As an introduction, we surveyed the mode of testing of Problem bacteria in individual PHLs against antibiotics - drugs of choice. Iw was important to find out whether strains belonging to Problem bacteria investigated are tested against sufficient number of antibacterial drugs. Our study shows that the percentage of bi- and multiple drug resistance in almost all bacterial species investigated depend on the number of antibiotics used in tests in vitro as single discs. The more antibiotic discs are used to test the strains, the more chance the laboratory has to register the true picture of multiresistance to antibiotics. Our study also shows that the testing in the PHLs associated to the computer study in this respect is inadequate. Moreover, the increasing complexity and proportion of multiple drug resistance in Problem Bacteria - with a notable exception of Salmonellae - forces the PHLs to use more and more discs so that using two Petri dishes full of discs - 12 to 15 discs - begins to be necessary in testing of most of the Problem bacteria under investigation.

Anti-Bacterial Agents↗
PubMed1975

Nation-wide survey of antibiotic resistance by means of a computer: bacterial strains from the urine, stool, and upper respiratory tract.

All-nation data of antibiotic resistance of about 200 000 bacterial strains isolated in the Slovak Socialist Republic in 1973 have been grouped, and compared, by means of a computer, into resistances of strains isolated from the urine, from upper respiratory tract (URT), from stool and from other pathological materials. In general, urine strains of all species investigated were found to be more resistant to "main antibiotics", and, suprisingly, to septrin, than strains from other sources. Strains of Staphylococcus aureus, and, notably, of Klebsiella-Enterobacter from the URT are generally more susceptible to antibiotics than strains of these species isolated from other sources. Urine strains of E. coli, P. mirabilis and Ps. aeruginosa show a high degree of resistance almost to all antibiotics, with exception of gentamicin and colistin (for E. coli and Ps. aeruginosa only). Further antibiotics for combatting these strains are urgently needed. Similar computer-assisted monitoring of strains from the very specified sources may be easily adapted for individual hospitals, clinics and even wards.

Anti-Bacterial Agents↗