PubMed Health⌕ Search

Biomedical subjects

J Guyot

Publications and source records attributed to J Guyot.

At least 19 recordsLinked to original sources
PubMed2006

[Infliximab--practical guidelines for the treatment of Crohn's disease].

Infliximab is a monoclonal chimeric antibody, with high affinity and specificity for tumour necrosis factor alpha (TNFalpha) that plays a central role in the pathogenesis of immune mediated inflammatory disorders including Crohn's disease and ulcerative colitis. Globally over 600000 patients have been treated with infliximab to date. This global experience led to a better definition of the overall safety and efficacy profile of this medication. The goal of the present recommendations is to provide practical information to physicians involved in the care of patients with inflammatory bowel disease.

Antibodies, Monoclonal↗
PubMed2006

[Inflammatory diseases of the intestines].

5-aminosalicylates preparations are not superior to placebo for the maintenance of medically-induced remission in patients with Crohn's disease. We have to reconsider the potential risks associated with inhibition of lymphocyte trafficking since it can induce serious and potentially lethal infections. Infliximab has shown efficacy in active ulcerative colitis.

Adrenal Cortex Hormones↗
PubMed2005

[Inflammatory bowel diseases].

COX-2 specific anti-inflammatory agents appear as able to induce a flare of inflammatory bowel disease as classical anti-inflammatory agents. The use of steroids, immunomodulators or infliximab prior to surgery does not appear to increase post-operative complication rates. Cases of hepatitis B reactivation have been described after infliximab therapy, suggesting that hepatitis B serological status should be verified prior to infliximab therapy. Adalimubab, a fully humanized antibody directed against TNF-alpha, is efficacious in patients that have lost response or did not tolerate infliximab. Approval of this agent is still awaited. Leucoapheresis is a promising tool in ulcerative colitis.

Humans↗
PubMed1998

[Anterior snapping of the hip associated with the ilial psoas].

UNLABELLED: Anterior snapping of the hip was first described in 1951 by Nunziata and Blumenfeld. The aim of this study, based upon a personal series and backed up by literature reports, is a current review of this common clinical condition, usually asymptomatic, but sometimes painful especially in athletes. MATERIAL AND METHOD: 12 cases in 11 patients were treated surgically: 4 men and 7 women, mean age 25 years, 7 of them regularly involved in sport. The onset of the snapping was sudden in 6 cases, related to a precise movement, while in 6 cases pain preceded the gradual development of snapping. Pain may coincide with snapping, or may be of a "chronic" nature after exercise. The problem had been present for 2 years on average before treatment. Surgery consisted of posterior psoas aponeurotic fascia division and was sufficient in 11 cases. In one patient, disappearance of snapping was obtained only after division of the ilio-femoral ligaments. Mean postoperative follow-up was 6.5 years (1 to 12 years). Pain disappeared in all patients. A slight, intermittent and asymptomatic snapping persisted in 3 cases. All athletes regained their previous performance level. DISCUSSION: CLINICAL: Symptoms consist of a dull, deep clicking sensation in the groin during active mobilization of the hip. It never occurs with passive mobilization. The entire problem is that of attributing painful symptomatology to snapping. ANATOMICAL STUDY: In almost all cases, snapping is due to a sudden movement of the psoas aponeurotic fascia on the ilio-pectinate eminence. Other causes have been reported: ilio-femoral ligaments on the femoral head, rectus femoris or psoas tendon on bony crests or of psoas on the cotyloid cup of an artificial hip. INVESTIGATIONS: These are primarily designed to rule out any other cause of snapping or inguinal pain (foreign body, acetabular labrum lesion, etc). Bursography and dynamic ultrasonography identify the snapping site, but it is sometimes difficult to confirm that this is responsible for painful symptoms. TREATMENT: If such responsibility is confirmed, and if any psychological component can be ruled out, this should first be "medical" by stretching and local injections in the serous bursa. Surgery should consist in division of the psoas aponeurotic fascia, leaving the muscle fibers intact. The procedure should be performed under sensory epidural anesthetic, the only way of ensuring peroperatively that snapping has disappeared. Division of the psoas distal tendon at the lesser trochanter is not appropriate.

Adolescent↗
PubMed1997

Study with two prokinetics in functional dyspepsia and GORD: domperidone vs. cisapride.

The HT4-agonist Cisapride (CIS) and the peripheral D2-antagonist Domperidone (DOMP) have distinct prokinetic actions. We compared their clinical efficacy in 127 dyspeptic patients. Patients with upper abdominal complaints of > 1 month duration, who had a normal UGE were allocated to the REFLUX-group (RG), (predominance of heartburn, acid regurgitation or retrosternal pain) or if devoid of this specific symptomatology to the DYSPEPSIA-group (DG) In a double-blind randomised fashion and allocated to 10 mg CIS or 20 mg DOMP qid (RG) or tid (DG) for 1 month and followed-up for further 2 months. In RG (N = 43, p < 0.05) the response rates were clearly in favour of CIS, but not in DG (N = 84). In RG DOMP was more effective against nausea. The benefit of both therapies was largely maintained in the follow-up period. Cisapride and domperidone were effective in the treatment of dyspepsia. Cisapride was more effective than domperidone in the REFLUX-Group.

Adult↗
PubMed1996

Ionophore properties of monensin derivatives studied on human erythrocytes by 23Na NMR and K+ and H+ potentiometry: relationship with antimicrobial and antimalarial activities.

Eight derivatives of monensin with a modified C25-C26 moiety were synthesized. Their ionophore properties were studied on human erythrocytes by measuring Na+ influx with 23Na NMR and concomitant K+ and H+ efflux by potentiometry. Modification of OH-26 led to inversion of selectivity of transport in favor of K+/Na+ in comparison with monensin. This selectivity disappeared by suppression of the C26-OH moiety. Finally the ionophore ability was lost if the head-to-tail chelation of the monensin skeleton was prevented by blocking the terminal OH-25 and -26 functions. All the compounds were inactive on Gram-negative bacteria and fungi. MIC measured on Bacillus cereus showed that derivatives with increased K+/Na+ selectivity were clearly the most active against Bacillus growth. Most of the compounds showed potential antimalarial properties in the nanomolar range when tested in vitro against Plasmodium falciparum. The IC50S measured were correlated with the whole Na+ and K+ transport efficiency rather than with the ionic selectivity. In both cases determination of initial fluxes of transport for both cations (Na+ and K+) was necessary to investigate the relationship between biological and ionophore properties.

Adult↗
PubMed1994

[Torticollis and C1-C2 rotation subluxation. Apropos of a case. The value of a dynamic scanner and of a 3-dimensional scanner].

The authors report the rare and complex case of a girl who had been followed since the age of 3 years for hydrocephalus the cause of which was found only when she was 6-year old. The causative agent was a pilocytic astrocytoma of the cerebellum. On April 10, 1990, she underwent subtotal excision of the tumour, associated with radiotherapy. Four months later she developed an increasingly painful and irreducible torticollis which did not respond to tractions. Dynamic CT scans and 3-dimensional CT scans were performed in the fourth month and provided a diagnosis of right C1-C2 rotatory subluxation. There was no history of injury and no sign of inflammatory process. Rotatory subluxation is a very rare lesion difficult to diagnose, and few cases have been published, although the signs are those of classical torticollis in children. When medical treatment fails, often due to belated diagnosis, the only surgical treatment is uni- or bilateral C1-C2 arthrodesis. If the diagnosis can be made at an early stage, reduction of the rotatory luxation is usually easy and without consequences to the child. It is therefore recommended to perform a dynamic CT scan and a 3D CT scan as soon as possible in all children with lasting painful torticollis.

Astrocytoma↗
PubMed1991

Phosphate-dependent sodium transport in S. faecalis investigated by 23Na and 31P NMR.

Na+ movements in S. faecalis were studied by 23Na NMR. They proved to be dependent on phosphate concentration in the buffer during the de-energization step. K+ and H+ were also studied respectively by potentiometry and 31P NMR and were shown not to be implicated. For de-energized cells the internal phosphate concentration, on the contrary, was directly linked to the external phosphate contained in the buffer. The experiments showed a Na+/Pi dependence in this prokaryote so far known only in eukaryotes.

Biological Transport↗
PubMed1991

[Thoracic pain and esophageal motility disorders].

These last years the clinical relevance of oesophageal disorders in the problem of chest pain has been more accurately defined. After exclusion of cardiac diseases with appropriate tests and of organic lesions of the oesophagus with upper endoscopy, the physician should look for: a gastro-oesophageal reflux disease with a 24-hour pH-metry, if possible coupled with a 24-hour oesophageal manometry. An oesophageal motor disorder, for example a diffuse spasm, with manometry with a provocation test. Confronted with disturbing chest pain, the capacity to determine their oesophageal origin represents not only a diagnostic but also a therapeutic help.

Chest Pain↗
PubMed1989

Study by NMR of the mode of action of monensin on Streptococcus faecalis de-energized and energized cells.

Streptococcus faecalis was used as a bacterial model for studying the mode of action of monensin by NMR investigations. Experiments were carried out in two states, characterized by several complementary methods: (i) the resting (de-energized) cell which was considered as an inert biological membrane, on which cationic transport induced by the ionophore alone can be investigated; (ii) the active (energized) cell where the ionophore-sensitive response of the living organism, particularly the cation pumps and the glycolysis, is probed. Studies of resting cells were performed, with changing external ionic concentrations, in the presence of monensin, which is preferentially a sodium carrier. Internal and external Na+ and H+ were followed by corresponding 23Na and 31P (inorganic phosphate) NMR resonances, K+ fluxes were measured by atomic absorption. It was shown that the induced cationic movements were linked to the existing ionic gradients for K+ and Na+. 31P and 13C NMR spectra for the intermediary metabolites detected in active cells showed that glycolysis is dramatically modified in the presence of monensin.

Adenosine Triphosphate↗
PubMed1989

[Screening for colorectal tumors using fecal occult blood studies].

Guaiac tests such as Hemoccult are widely used but are affected by several factors. Occult blood testing does uncover subclinical colorectal cancer often at early stage, but a favorable effect on survival remains to be proven. The sensitivity for the detection of malignancies is from moderate to good, but it is poor for benign polyps. Predictive value of a positive test for cancer ist about 8-12%. Thus, most of the individuals with a positive test would not need colonic investigations. Recommendations relating to the testing for of occult blood could change rapidly with the new immunologic techniques or with new data on mortality coming from controlled clinical trial now being conducted.

Colorectal Neoplasms↗
PubMed1986

Gastric ulcer: a double-blind comparison of 100 mg pirenzepine plus antacid versus 800 mg cimetidine plus antacid.

Fifty-five patients with endoscopically confirmed gastric ulcers received either cimetidine (28 patients) or pirenzepine (27 patients) in a randomized double-blind manner. Fifty-seven per cent of the patients treated with cimetidine and 48% of those treated with pirenzepine presented with endoscopically healed ulcers after 4 weeks of treatment. By 8 weeks complete healing had occurred in 83% of the patients taking cimetidine and 76% of those taking pirenzepine. These differences were not statistically significant. Severity of pain on entering the study was correlated with slower healing of the ulcer. Side effects occurred in 5 of 27 patients in the pirenzepine group and 3 of 28 in the cimetidine group. They were mostly mild and did not differ from side effects observed in other studies.

Antacids↗
PubMed1984

Ionophoric activity of the antibiotic X.14547 A in the mitochondrial membrane.

Release of Ca++, Mg++ and K+ by the carboxylic ionophore X-14547 A was studied in the mitochondrial membrane. A comparison was made with A.23187 ( Calcimycin ) and X.537 A (Lasalocid A) under the same experimental conditions. It was shown that in this test system X.14547 A is primarily a K+ carrier comparable with X.537 A.

Animals↗