Food and malformation.
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Biomedical subjects
Publications and source records attributed to J H Renwick.
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In this study, we have attempted to detect and describe patterns in the arrangement of gene loci within chromosomes of a metazoon. Known loci (842 of them) on the first three chromosomes of Drosophila melanogaster have been characterised according to a list of 45 properties and the distributions of these properties have been examined systematically. For all these properties, there is little, if any, evidence of clustering between known loci that are not close enough to belong to the same 10-locus group. Our analysis has, however, revealed evidence confirming that some properties show a tendency to cluster within a 10-locus group. Even this tendency is not strong, except for some of the morphological properties. However, it is apparently at variance with the findings of Elston and Glassman (1967), based on fewer data.
The peak acid output of the stomach in a group of 71 mothers of spina bifida children and in 71 matched controls was estimated indirectly by the serum level of group I pepsinogens. The mean levels did not differ significantly, suggesting that the conjectured teratogen is not specially acid-labile. The variance was significantly higher in index subjects than in controls, but the interpretation of this finding is not clear.
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