Hypothesis: anencephaly and spina bifida are usually preventable by avoidance of a specific but unidentified substance present in certain potato tubers.
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Biomedical subjects
Publications and source records attributed to J H Renwick.
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Multiple self-healing squamous epithelioma is determined by a rare autosomal allele in heterozygous state and affects both sexes with approximately equal severity. The lesions are found more frequently on exposed areas of skin and their distribution correspondingly differs between the sexes. Reliable information on 62 cases has been obtained in the west of Scotland. This number of patients is more than twice that recorded in the world literature. It seems possible that the Scottish cases have arisen from a single mutation occurring before 1790.
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Synthesis of lactate dehydrogenase in somatic and gametic tissues of certain avian and mammalian species is controlled by alleles at three loci, A, B, and C. We report breeding experiments with pigeons that conclusively demonstrate linkage between the B and C structural loci in this species. The most probable recombination fraction is zero, and contiguity is not excluded. The upper 95 percent probability limit is 4.5 percent. This tight linkage of two loci that produce closely similar polypeptides suggests that the loci acquired their separate identities through a duplication event. Further-more, the existence of recognizable B- and C-type polypeptides in both the bird and the mammal suggests that the event and the resulting linkage preceded the separation of these fauna. If so, then the linkage has persisted for a very long time.
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