PubMed Health⌕ Search

Biomedical subjects

J H Tripp

Publications and source records attributed to J H Tripp.

At least 73 records · Page 4Linked to original sources
PubMed1980

Yeast opsonisation in children with chronic diarrhoeal states.

Four patients with defective yeast opsonisation and protracted diarrhoea are reported. Plasma infusions improved the opsonising function in all 4 and the diarrhoea in 3. This immunological abnormality was assessed in 100 sequential patients with chronic diarrhoea associated with various gastrointestinal disorders; 52 with protracted diarrhoea and failure to thrive of undetermined cause, 26 with 'toddler diarrhoea', 8 with coeliac disease, 5 with chronic inflammatory bowel disease, and 9 with miscellaneous disorders. 23% of the patients with protracted diarrhoea of undetermined cause had defective opsonisation, a greater proportion (P less than 0.05) than that in 'toddler diarrhoea' or the remaining patients, in whom the frequency (4%) was similar to that (5%) in healthy populations. We suggest that yeast opsonisation be tested in children with protracted diarrhoea, as plasma infusions can be an effective form of treatment.

Child, Preschool↗
PubMed1980

Mucosal (Na+-K+)-ATPase and adenylate cyclase activities in children with toddler diarrhea and the postenteritis syndrome.

Assays for (Na+-K+)-ATPase and basal, fluoride stimulated and percentage of activation of adenylate cyclase have been established for small portions of human jejunal biopsies. Control means and ranges have been established for each activity in a group of children with failure to thrive but no gastrointestinal disease. Activities of (Na+-K+)-ATPase and percentage of activation and basal activity of adenylate cyclase are increased in children with toddler diarrhea. (Na+-K+)-ATPase activity is reduced in children with active postenteritis syndrome, and recovery from this syndrome is associated with an increase in this activity and of percentage of activation and basal activity of adenylate cyclase.

Acute Disease↗
PubMed1978

Echovirus encephalitis and myositis in primary immunoglobulin deficiency.

Two children are described with primary hypogammaglobulinaemia and encephalitis associated with echovirus infection. One also developed a condition resembling dermatomyositis which improved after he was given infusions of plasma containing antibody to the echovirus. Although both died of their encephalitis, the course of the brain disease in one of them may have been prolonged by treatment with specific antibody. These cases, together with another briefly mentioned case in an adult with congenital hypogammaglobulinaemia and echovirus infection, indicate that these patients are particularly susceptible to echoviruses.

Agammaglobulinemia↗
PubMed1977

Gastroenteritis: a continuing problem of child health in Britain.

A paediatric gastroenteritis unit had 608 admissions over 2 years. The children admitted were mostly under 6 months of age, had often been in hospital previously and were, as a group, underweight for their age. Severe biochemical disturbances, early complications, and death were significantly related and were almost entirely confined to the children under 6 months of age. There were 8 deaths (1-3%), 5 (0-8%) of which were associated with serious underlying disorders. Late complications related to food intolerance were found in 3%. Young infants with gastroenteritis are best cared for in units experienced in the management of acute metabolic disturbances in such patients, though highly specialised renal and gastrointestinal services are not essential. These units should provide continuing paediatric supervision.

Dehydration↗
PubMed1977

Effect of torso geometry on the magnetocardiogram.

Calculations of the effect of torso geometry on the extracorporeal magnetic field produced by a simple cardiac source have been carried out. Contrary to the results at present in the literature, it is found that the field solution is stable under perturbations of geometry in the sense that small relative changes in geometry produce comparably small changes in the magnetic field. Thus, simplified torso models may have a wider range of validity and usefulness than was previously thought.

Heart Function Tests↗
PubMed1977

Juvenile Gaucher's disease with horizontal gaze palsy in three siblings.

Three children in a West African family had Gaucher's disease of juvenile onset (Type 3), and all showed an identical neurological disorder. The diagnosis was substantiated by histochemical demonstration of Gaucher cells in bone marrow, liver, and spleen, the finding of an excess of glucosyl ceramides in a liver extract, and a deficient activity of the enzyme beta-glucosidase in cultured skin fibroblasts. The neurological picture was characterised by myoclonic epilepsy, muscle wasting, hypotonia, pyramidal signs, some intellectual deterioration, and a striking disturbance of eye movements. The latter appears to result from specific involvement of the supranuclear pathways subserving lateral gaze. The distinctive features of this clinical syndrome are emphasised.

Age Factors↗
PubMed1976

Modification to single catheter exchange transfusion technique.

A simple modification to the standard 'in-out' exchange transfusion technique is described which requires cannulation of the umbilical vein only, yet provides many of the theoretical and practical advantages of a 2-catheter arteriovenous technique. The advantages include a reduction of cardiovascular disturbance; a reduction of the inevitable pressure changes in the portal venous system (probably important in the pathogenesis of complicating necrotizing enterocolitis); administration of alkali or drugs diluted in donor blood; accurate assessment of balance; a more efficient exchange; and general ease of management allowing better clinical observation of the infant.

Acidosis, Respiratory↗
PubMed1975

Hypertension, oedema, and suppressed renin aldosterone system due to unsupervised salt administration.

This paper describes an infant with gastroenteritis, who developed hypertension and oedema after administration of inaccurately prepared oral glucose salt solution. The renin aldosterone system was suppressed in this child and it was suggested that this may be a factor in the development of hypernatraemia when abnormal water losses occur in infants fed on hyperosmolar feeds. Unless salt can be given accurately in small amounts it may be safer to advise feeds of glucose only in infants with mild diarrhoea.

Aldosterone↗
PubMed1968

The slowing of gastric emptying by monosaccharides and disaccharides in test meals.

1. Test meals containing various concentrations of glucose, maltose, sucrose, fructose, lactose, galactose and mixtures of these solutes were given to six healthy subjects. All meals contained 40 mM sodium citrate.2. The slowing of gastric emptying produced by the disaccharides in test meals was generally consistent with the stimulation of duodenal osmoreceptors occuring after the hydrolysis of the disaccharides.3. Glucose was slightly more effective, per osmole, in slowing gastric emptying than was galactose.4. By comparison with glucose or galactose, fructose was much less effective in slowing gastric emptying. In three subjects out of six there was a threshold for its effect.5. The results may be indicative of the relative activities of disaccharidases in the brush border of the small intestine. They are consistent with there being an osmoreceptor deep to these enzymes which slows gastric emptying.

Adult↗
PubMedDate not supplied

Illness experience and children's concepts of health and illness.

The effects of chronic illness on children's knowledge of health and illness were investigated by interviewing 57 children with diabetes and the same number of healthy children of similar age and background. There were few differences between the groups in their definitions of health or knowledge of the cause of illness. The data are discussed in terms of their theoretical relevance to the development of ideas about health and illness.

Adolescent↗
PubMedDate not supplied

Illness experience and related knowledge amongst children with asthma.

Forty-nine children with asthma (aged 7-16 years) completed a questionnaire concerned with (1) general knowledge about the body and how it works, and (2) specific knowledge about the cause and prognosis of asthma, knowledge of allergens and self-care behaviours. Compared with a matched group of healthy children, they were less well-informed about general knowledge of the body. Knowledge of asthma was also poor. Few children made any specific attempts to avoid situations known to precipitate attacks. There was no significant increase with age in knowledge of allergens or awareness of how to control attacks. The results indicate a need to make asthmatic children more aware of their illness, particularly with regard to self-care.

Adolescent↗