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J Hébert

Publications and source records attributed to J Hébert.

95 records · Page 6Linked to original sources
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Quantitative analysis of T and B cell subsets in healthy and sick premature infants.

This work proposes a serial quantitative analysis of the numbers and percentages of B and T cell subsets in 104 consecutive premature infants (PI) between birth and six months of age as compared with 21 normal term infants. First, in order to ascertain the effects of perinatal distress at birth (respiratory distress, neonatal asphyxia) on certain parameters of the immune system, the PI were divided into two groups. One comprised 36 healthy preterms, the other, 68 preterms with perinatal distress. It was then shown that healthy PI differed from full-term infants by their higher absolute numbers of T cells (CD2-positive) and helper T cell subset (CD4-positive). These increases in CD2- and CD4-positive cells correlated with gestational age (GA). An increase in B lymphocytes (CD20-positive cells) was also documented but no correlation with GA could be seen. Secondly, perinatal distress was found to be concomitant with transient decrease in percentages and absolute numbers of CD2- and CD4-positive cells, particularly in PI of less than 28 weeks of gestation. The B cells (CD20- and CD21-positive cells) were not different in absolute numbers. Respiratory distress had a more discernable effect than fetal asphyxia on the immune system. Finally, no immunological parameters tested could at any time predict the occurrence of infection in PI during the first 6 months of life.

Antigens, CD↗
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Onset of action of loratadine and placebo and other efficacy variables in patients with seasonal allergic rhinitis.

In a double-blind study, 185 patients with seasonal allergic rhinitis were randomly assigned to receive 10 mg of loratadine or placebo once daily for three days. On day 1 of treatment, the onset of relief of symptoms within 30 minutes of drug administration was reported by 13% of the loratadine-treated patients and by 4% of the placebo patients (P less than 0.05). At two hours after drug administration, 65% of the loratadine-treated patients and 48% of the placebo patients reported symptom relief. On day 3, the loratadine-treated patients reported a significantly greater relief of symptoms, and according to both physician and patient evaluations, the treatment response was significantly superior in the loratadine-treated than in the placebo patients. The incidence of sedation was 2% in the loratadine group and 1% in the placebo group.

Adolescent↗
PubMedDate not supplied

Fresh venous femoral autografts and allografts as carotid substitutes in matched dogs from the same litter.

Pathological and biochemical investigations were performed on femoral veins used as fresh autografts and allograft substitutes in the carotid arteries of dogs from the same litter and separated in two groups described as compatible and incompatible after a mixed leukocyte culture (MLC). After 5 months of implantation, all the arterial substitutes were patent. The analyses gave the following results: 1. The haematologic parameters were not affected by the grafts. 2. Light microscopy (LM) and scanning electron microscopy (SEM) indicate a thrombotic accumulation and the presence of inflammatory cells in the compatible and the incompatible allografts. The occurrence of pathological changes was more pronounced in the incompatible group. 3. Immunostaining of anti-factor VIII-related antigen reveals a better preservation of the endothelial cell wall on the autograft. 4. The 6-keto-PGF1 alpha/TXB2 ratios of the autografts and the compatible allografts were similar.

6-Ketoprostaglandin F1 alpha↗