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J Haot

Publications and source records attributed to J Haot.

At least 91 records · Page 5Linked to original sources
PubMed1965

Lymphoma growth in vivo: electronic discrimination between tumor and stroma cells.

Moloney lymphoma cells are larger than normal cells of mouse spleen, lymph-node, and thymus. Use of electronic cell-size anaylsis in conjunction with specific immunocytolysis permits difjerential counting of host and tumor cells. Increase of lymphoma cells occurs first in spleen and then in lymph nodes; in thymus it occurs only during the terminal stages of tumor growth.

Animals↗
PubMedDate not supplied

Evaluation of the role of human papillomavirus in oesophageal squamous cell carcinoma in Belgium.

OBJECTIVE: To evaluate the putative role of human papillomavirus (HPV) in the aetiology of oesophageal squamous cell carcinoma (OSCC) in Belgium. METHODS: The frequency of HPV infection was determined using HPV DNA PCRamplification with L1 consensus primers MY09-MY11, able to recognise about 40 different HPV types, on twenty-one formalin-fixed and paraffin-embedded oesophageal squamous cells carcinomas. Nineteen samples of histologically normal epithelium from the surgical margins of the OSCC specimens and five samples from normal oesophagus obtained at autopsy served as negative controls. RESULTS: We found only one HPV positive tumour (4.8%) out of the 21 OSCC cases. All the normal epithelium controls remained negative. CONCLUSIONS: Our data are in agreement with those previously published, suggesting that HPV infection only plays a minor role in the pathogenesis of oesophageal squamous cells carcinoma in West-European countries.

Adult↗
PubMedDate not supplied

[Critical study of digestive tract dysplasia].

Dysplasia designate the presence in a tissue of atypical architectural and cytological features similar to those observed in carcinogenesis. It must be clearly distinguished from metaplasia which is, in itself, a benign state characterized by the progressive replacement of a normal tissue by an other, normally foreign to this organ. Although the theoretical definition of dysplasia and its relation to carcinogenesis is well demonstrated, numerous difficulties remain regarding its classification and clinical applications. Recent research based on follow-up studies and on diagnostic reproducibility have somewhat clarified the problem, leading to a simplification of the classification in two tiers (high and low grade). High grade dysplasia can be considered as a high cancer risk necessitating a follow-up at short intervals and possibly requiring surgery. Low grade dysplasia, which can regress or progress very slowly represents a low cancer risk. After a first control at one or two months, it is suggested that endoscopic follow-up can be proposed at larger intervals (one or two years). The authors study the aspects of the dysplasia at the different levels of the gastrointestinal tract and summarise the clinical implication of this diagnosis.

Adenoma↗
PubMedDate not supplied

[Celiac disease in adults: clinical aspects--role of endoscopy].

Adult coeliac disease has a broad clinical spectrum and remains undetected for years. Among subclinical deficiency states, attributable to coeliac enteropathy, combined iron and folic acid malabsorption is predominant. An unexplained recurrent iron anaemia is an indication for small intestinal biopsy. Gastro-intestinal disorders are present in only 50% of the cases. Coeliac disease is frequently associated with other major histocompatibility complex (MMC)-linked diseases which are mediated by immunological mechanisms: dermatitis herpetiformis, oral ulcerations, IgA nephropathy, rheumatoid arthritis, sarcoidosis. Dermatitis herpetiformis is a useful model for examination of the spectrum of mucosal changes that typify gluten sensitivity and subliminal lesions without villous atrophy. An increased interest is devoted to the intra-epithelial T-lymphocyte population, not only in the small intestine, but at the level of the stomach and the colon. A "rectal challenge" test has been proposed for detecting gluten sensitivity in coeliac patients. Such a test could be an original method of screening, reducing so the need of small intestinal biopsy. The preliminary results are to be confirmed. Until now, jejunoscopy remains mandatory for the diagnosis and the survey of intestinal lesions related to coeliac disease.

Adult↗
PubMedDate not supplied

[Stomach cancer: surgical experience in the clinics of the Louvain University (UCL) 1969-1986].

Gastric carcinoma: surgical experience at the University of Louvain Clinics from 1969 to 1986. From january 1969 to june 1986, 201 gastrectomies were performed for gastric adenocarcinoma (curative resection in 81%, palliative resection in 19% of the patients). Hospital postoperative mortality was 6.9%. Five and ten year actuarial survival rates were, +/- 4% and 34 +/- 7%, respectively. In this series, there was a rather high percentage of early gastric carcinoma (23% of the patients), with, as expected, a high actuarial 5 year survival rate: 90 +/- 6%.

Actuarial Analysis↗
PubMedDate not supplied

[Lymphocytic gastritis].

Lymphocytic gastritis is a new histopathological entity characterized by a dense lymphocytic infiltration of the gastric surface and pit epithelium. The diagnosis relies upon lymphocyte counts which are always far beyond the values obtained in other types of gastritis. The clinical presentation of lymphocytic gastritis is characterized, in the majority of cases, by weight loss and anorexia. Endoscopically it corresponds to a complex pattern of enlarged rugae and often eroded (aphthoïd) nodules. Our studies have shown a close correlation between lymphocytic gastritis and diffuse or corporeal varioliform gastritis. On the contrary, there is no relationship between lymphocytic gastritis and antral varioliform gastritis which exhibits heterogeneous histological features. Lymphocytic gastritis is a chronic disease which can evolve over long periods; it can however cure spontaneously (about half of the cases) after a delay of one to two years. The aetiology and pathogenesis are unknown. The histological similarity with coeliac disease suggests a possible role of immunological factors.

Chronic Disease↗