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Biomedical subjects

J Harada

Publications and source records attributed to J Harada.

At least 91 records · Page 5Linked to original sources
PubMed1987

A consideration on the new classification of latest lung ventilators.

Concerning the classification of ventilators, Elam (1958), Faireley (1959), and Hunter (1961) reported some simple ones such as pressure limited, volume limited, pressure preset, or volume preset models. Mapleson (1969) also classified them by the generating force or cycling together with the above-mentioned types. The latest ventilators applicable to patients with respiratory failure usually have some cut-off function at high airway pressures as a safety measure. Therefore, all of them belong to the pressure limited type. Some ventilators are of two types such as the time cycled and pressure cycled type. Therefore, we attempted to classify ventilators into four groups, i.e. the time cycled, volume cycled, pressure cycled and selective time-pressure cycled types according to the fundamental mode of ventilator function, the so-called change of cycling from inspiration to expiration. Each group was further divided into subgroups according to preset dials such as respiratory rate, I/E ratio, inspiration time, expiration time, tidal volume, flow rate and airway pressure. By this method, fifty one ventilators on the market in Japan can be classified without overlapping. Although this classification seems complex, it will be of use in selecting ventilators by emphasizing preset dials according to the user's needs, ability or both.

Journal Article↗
PubMed1987

[The Su-polysaccharide skin test in lung cancer].

Skin testing with intradermally injected Su-Polysaccharide (extracted from Su strain Streptococcus bacteria) was performed in 41 cases of lung cancer. Su-polysaccharide skin test results were correlated, to some extent, with the patient's age, clinical stage and performance status and showed a similar trend to the simultaneously performed PPD skin test. These results suggested the potential usefulness of Su-Polysaccharide skin test results as one of the parameters of immunological status of patients with lung cancer. It was also demonstrated that skin reaction to Su-Polysaccharide was increased specifically after OK-432 immunotherapy and was well correlated with the prognosis of the disease. The Su-Polysaccharide skin test was thus considered to be a useful parameter for monitoring the immune response to OK-432 immunotherapy in lung cancer and also one of the parameters of prognostic value.

Adult↗
PubMed1987

[A case of the duplicate origin of right vertebral artery].

A 70-year-old woman was admitted to our hospital with complaints of head heaviness and dizziness. Right vertebral angiogram demonstrated a duplicate origin of right vertebral artery with kinking at the both origins. Medical treatment was started immediately, but any improvement could not be obtained. So, surgical correction was attempted for the kinkings and the head heaviness and dizziness disappeared postoperatively. Duplicate origin of right vertebral artery could be confirmed at operation. Six cases of duplicate origin of vertebral artery were analyzed from the literature with special considerations to the genesis.

Aged↗
PubMed1985

[Value and problems of magnetic resonance imaging in the diagnosis of aortic dissection].

Nuclear magnetic resonance imaging was performed for 14 patients with aortic dissection using a 0.15 T resistive magnetic imaging system (Toshiba MRT-15A). The diagnosis was confirmed by X-ray computed tomography. The scan time was 15 minutes, and five or 10 slices were obtained simultaneously. The imaging was made using spin echo method (repetition time: TR = 200-800 msec, and echo delay time: TE = 40 msec). The natural contrast between flowing blood and stationary material permits the clear demonstration of the intimal flap of aortic dissection. The intimal flap was demonstrated in seven cases as a curvilinear high intensity band within the dilated aorta in consecutive sections. The rapidly flowing blood in the narrow true lumen produced little or no signal, while eddy currents within the false lumen usually produced signals. The thrombi in the false lumen had high intensity. In seven cases, the false lumen was completely filled with thrombi and the intimal flap could not be observed on nuclear magnetic resonance images.

Aortic Dissection↗
PubMed1983

Combination chemotherapy for small cell carcinoma of the lung: evaluation of four-drug combination of cyclophosphamide, vincristine, methotrexate, and procarbazine.

Forty-one patients with small cell carcinoma of the lung were treated with a four-drug combination of cyclophosphamide, vincristine, methotrexate, and procarbazine. The response rate was 68% (28 responded among 41 patients), with 10 complete responses (24%) and 18 partial responses (44%). The median survival time from the initiation of chemotherapy was 11 months for patients with limited disease and 8 months for those with extensive disease. Patients who achieved complete response survived significantly longer than those who did not; the median survival time for complete responders was 14.5 months, compared to 8.5 months for partial responders and 6 months for non-responders. Myelosuppressive toxicity remained within acceptable limits, with 5% incidence of leukocytopenia (less than 1,000/microliter) and 7% incidence of thrombocytopenia (less than 50,000/microliter) following the first course of the regimen.

Adult↗
PubMed1983

[Intrathoracic administration of adriamycin with closed tube thoracostomy drainage for malignant pleuritis: observation on the administration dosage].

The effect of intrathoracic administration of adriamycin with closed tube thoracostomy drainage was investigated on patients with various malignant pleural effusions (13 lung cancer and one each stomach, breast, ovarian cancer, respectively). The doses of adriamycin ranged from 50, 30, 20, to 10 mg given to four groups of 4 cases respectively. Comparative study on effective rates, survival period after the administration, side effects and histopathological changes in autopsied cases was performed. The results obtained were as follows: 1. With regard to effective rates and histopathological changes, no difference was observed in the four groups in term of dose escalation of Adriamycin. 2. 50% survival period was similar within the groups administered 20, 30 and 50 mg of Adriamycin. However, the group receiving 10 mg showed slightly shorter survival period. 3. Although serious side effects were not observed in any groups, minor toxicities were mostly encountered in the 50 mg group. 4. It was concluded that in the treatment of malignant pleural effusion, an appropriate dose of intrathoracic administration of adriamycin was about 20-30 mg.

Adenocarcinoma↗
PubMed1982

Bone marrow examination for detection of metastasis in patients with bronchogenic carcinoma: an evaluation of 107 patients.

As a staging procedure before treatment, examination of bone marrow from the posterior iliac crest was performed on a total of 107 patients with bronchogenic carcinoma. Among them, 11 patients (10.3%) had metastasis in the bone marrow: five of 39 adenocarcinomas, five of 33 small cell carcinomas, one of four large cell carcinomas, and none of 31 epidermoid carcinomas. Leukoerythroblastosis was found exclusively in the patients with metastasis, although the presence of tumor cells in the bone marrow did not correlate well with peripheral blood cell counts. Survival following an intensive chemotherapy in patients with bone marrow metastasis was substantially longer for those with small cell carcinoma than for those with other histologic types of bronchogenic carcinoma.

Biopsy↗