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Biomedical subjects

J I Sebes

Publications and source records attributed to J I Sebes.

At least 37 records · Page 2Linked to original sources
PubMed1986

Skeletal surveys in multiple myeloma. Radiologic-clinical correlation.

Thirty-three patients with multiple myeloma were studied with serial skeletal surveys, serum immunoglobulin levels, and postabsorptive urinary hydroxyproline (Spot-HYPRO) determinations. Twenty receiving chemotherapy were also followed with skeletal surveys in order to evaluate bone response to treatment. A close association was found between skeletal findings and changes in immunoglobulin levels with positive correlation in 71% of the patients. A similar association was found between skeletal disease and Spot-HYPRO level changes in 65%. Five of 12 patients (42%) with partial or complete clinical response to chemotherapy, demonstrated improvement in the appearance of skeletal lesions. Positive correlation between the roentgenographic changes and clinical markers of myeloma as well as therapeutic response, indicates that skeletal surveys are useful and effective in monitoring patients with multiple myeloma.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1986

Sickle cell gnathopathy: radiologic assessment.

To provide objective evaluation of sickle cell gnathopathy, lateral skull radiographs of fifty patients with sickle cell anemia and twenty-five controls, matched for age and sex, were evaluated with respect to hard palate length and palate--alveolar ridge (PAR) angle. These measurements were compared to the angle formed between sella, nasion, and a point just below the anterior nasal spine of the maxilla (SNA angle), which is widely used in evaluation of the midfacial skeletal profile. The maxillary protrusion was found to be due to an increase in the PAR angle, as there was significant difference in this measurement between the two groups while there was no difference in the hard palate and SNA angle measurements. In keeping with prior explanations, marrow hyperplasia is the cause of maxillary overgrowth. Although often detected clinically, sickle cell gnathopathy can be evaluated radiographically simply and accurately by measurement of the PAR angle.

Adolescent↗
PubMed1985

Radiologic assessment of bone and joint disease. I. Magnification radiology.

The advantages and limitations of magnification techniques are presented. Optical and geometrical techniques each have their proponents. The geometrical technique has proven valuable in the assessment of trauma, metabolic bone disease, arthritis, osteomyelitis, and neoplasm. It often shows pathology inapparent on conventional radiographs.

Arthritis↗
PubMed1984

Pelvic extramedullary hematopoiesis.

Extramedullary hematopoiesis is an infrequent cause of thoracic masses. Extrathoracic locations are even less common. We have studied two patients, one with suspected pelvic neoplasm, with technetium-99m sulfur colloid marrow image and transmission computerized tomography. This noninvasive evaluation established the diagnosis of pelvic extramedullary hematopoiesis in both. We recommend a similar diagnostic approach in patients with chronic anemia or other predisposing disease, presenting with a pelvic or abdominal mass.

Adult↗
PubMed1983

The manubriosternal joint in rheumatoid disease.

Manubriosternal joint abnormalities are often undetected causes of chest pain. Twenty-five normal patients and 40 cadaver specimens were evaluated to establish the normal radiographic anatomy of this articulation. Analysis of the manubriosternal joint was carried out in rheumatoid diseases in order to ascertain the incidence and variety of abnormalities. Twenty-seven of 100 manubriosternal joints were abnormal in rheumatoid arthritis. Of 25 patients with ankylosing spondylitis 20 (80%) revealed abnormalities either with erosions or fusion. None of 25 patients with psoriatic arthritis and none of 20 with Reiter syndrome showed erosions or ankylosis. The articulation should be evaluated in rheumatoid diseases and in non-arthritic patients with chest and/or shoulder pain.

Adult↗
PubMed1983

Terminal phalangeal sclerosis in sickle cell disease.

Hand films of 100 patients with sickle cell disease were analyzed in order to establish the type, distribution, and incidence of terminal phalangeal sclerosis. Fifty hand films from patients with no known sickle cell disease matched for age and race were also studied. Twenty-four of 100 patients with sickle cell disease, with 14 less than 20 years old, showed clear evidence of terminal phalangeal sclerosis, while only 10% of the controls were positive. The incidence was significantly different from the control group (chi 2 = 4.1949, d.f. = 1, p less than 0.05) suggesting that terminal phalangeal sclerosis is a significant finding in a young patient with sickle cell disease.

Adolescent↗
PubMed1983

The supine view in double-contrast knee arthrography.

Knee arthrography is a widely used diagnostic procedure, but there is disagreement regarding the relative efficacy of single vs. double-contrast examinations in the evaluation for meniscal tears. In 353 double-contrast knee arthrograms, combining supine positioning with the routinely accepted prone views, there were 222 meniscal tears diagnosed using prone positioning alone, and seven additional tears were found with the added supine maneuver. Even though the knee joint was distended with both contrast material and air, the prone views tended to outline the meniscus in a double-contrast fashion, whereas the supine views provided single positive contrast detail of the same area. Supine views are particularly helpful when an obvious meniscal tear is not fluoroscopically apparent during prone filming.

Adolescent↗
PubMed1983

Avascular necrosis of the hip in the sickle cell hemoglobinopathies.

Two hundred and eighty-one patients with sickle cell disease were studied clinically and radiographically with emphasis on diagnosis of epiphyseal abnormalities and potential complications of hip replacement. Nineteen percent of patients with hemoglobin SS disease had avascular necrosis of the femoral head (ANF) while a 9% incidence was found in hemoglobin SC disease. Twenty of 47 patients with ANF had no hip pain. The degree of anemia did not correlate well with symptoms. Thirteen patients with avascular necrosis of the hip underwent hip replacement and four developed prosthesis-related complications.

Adult↗
PubMed1981

Calcaneal abnormalities and erosive bone disease associated with sickle cell anemia.

Although the arthritis of sickle cell anemia has generally been considered noninflammatory, published studies suggest the existence of an inflammatory variety. The common association of bone abnormalities with inflammatory arthritis precipitated a radiographic evaluation of 100 patients, chosen at random from those followed at the University of Tennessee Sickle Cell Center. Erosive disease was identified in 14 percent. This was correlated with clinical manifestations in a longitudinal manner. Loss of definition of the cortical margin in the superior aspect of the calcaneus appears to be erosive in nature. It has not been observed previously and may be pathognomonic for sickle cell anemia. Arthrographic and gross pathologic material is presented in support of this hypothesis.

Adolescent↗
PubMed1980

Cerebral infarction secondary to sickle cell disease: arteriographic findings.

Cerebral angiograms were performed in 14 children with sickle cell disease and clinical findings of cerebral infarction. The angiogram was normal in four patients. Ten patients had abnormalities in the carotid artery or its branches. The internal carotid artery was stenosed or occluded usually with bilateral disease. The anterior and middle cerebral arteries were involved in nine patients and branch occlusion was frequent. The posterior fossa arteries were not involved in these patients. The risk of angiography is low if appropriate precautions are taken. In these patients the indications for arteriography were to evaluate the effects of hypertransfusion therapy on cerebrovascular disease.

Adolescent↗
PubMed1980

Hypertrophic osteoarthropathy associated with carcinoma of the esophagus. Report of a case lacking pleuropulmonary involvement and review of the literature.

There have been no previous reports of hypertrophic osteoarthropathy associated with carcinoma of the esophagus lacking pulmonary or pleural involvement. The first such case is described with autopsy findings confirming the diagnosis. In addition a review of the literature concerning hypertrophic osteoarthropathy and its known associations is presented.

Carcinoma, Squamous Cell↗
PubMed1979

Radiographic changes of the skull in sickle cell anemia.

Skull radiographs of 194 patients from 4 months to 55 years old with sickle cell anemia revealed porous decreased bone density in 25%, widening of diploë associated with a relative decrease in the width of the outer table in 22%, and vertical "hair-on-end" striations in 5%. The youngest patient with vertical striations was 5 years old and the oldest was 39. Serial examinations in 60 patients revealed no decrease of the skull width nor disappearance of the striations with age.

Adolescent↗
PubMed1978

The relationship between HLA-B27 positive peripheral arthritis and sacroiliitis.

HLA typing for B27 antigen is a helpful diagnostic aid in the classification of peripheral arthritis patients (especially young patients) who are rheumatoid factor negative. We studied 109 patients with seronegative peripheral arthritis belonging to various clinical categories; 23% proved to be B27 positive in comparison to 7% of normal controls. In spite of a paucity of spinal manifestations there was a high prevalence of sacroiliitis (83%) in the B27 positive peripheral arthritis patients as opposed to only 21% in those without B27 antigen. HLA-B27 typing and radiographs of the sacroiliac joints are important differential tests.

Adolescent↗