Biomedical subjects

J I Sebes

Publications and source records attributed to J I Sebes.

42 records · Page 3Linked to original sources

PubMed1977

Carcinogenic effect of N-methyl-N'-nitro-N-nitrosoguanidine and fission neutron irradiation in rats.

Examinations were made on the carcinogenic effects of a chemical compound, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), and a physical carcinogen, whole-body irradiation with fission neutrons, on the gastrointestinal tract of male albino Sprague-Dawley rats. The carcinogens were used singly and together in order to investigate their possible synergistic effects on the induction of adenocarcinomas of the stomach and small intestine. Of the 13 animals treated with the chemical, MNNG, and living more than 9 months, 9 showed gross tumors (5 gastric and 4 duodenal), confirming the high incidence of gastrointestinal carcinomas induced by MNNG in the rat. There were no gastrointestinal tumors found after neutron exposure. When the 2 carcinogens were combined, no additivity or synergism occurred. After neutron irradiation, a dental syndrome with loss of incisor teeth was observed. The effect of neutron irradiation on subgingival pathology of the teeth is being investigated.

Adenocarcinoma↗

PubMed1976

The relationship between radiographic findings and asymmetrical radioactivity in the shoulder.

A prospective study was performed to compare asymmetrical radioactivity in the shoulder on 99mTc bone scans with the conventional radiographic findings of 100 right-handed and 8 left-handed patients. Of the 100 right-handed patients, 30 had increased radioactivity in the right shoulder; 5 showed increased radioactivity on the left. Clinical history, shoulder physical examination, and site of injection did not influence the frequency of asymmetrical radioactivity; only dominant handedness correlated with this finding.

Adolescent↗

PubMed1976

Lung abscess and osteomyelitis of rib due to Yersinia enterocolitica.

The first reported case of infection of the lung and bone with Yersinia enterocolitica is described. This organism has only recently been known to infect humans. Although a wide spectrum of diseases has been described, all have appeared to be relatively benign; however, in our case a rapid necrotizing process occurred. Therefore, the aggressive nature of this organism outside its usual surroundings, eg, the gastrointestinal tract, is worth noting.

Aged↗

PubMed1975

Histopathologic changes induced in rats by localized x-irradiation of an exteriorized segment of the small intestine.

The sequence of histopathological changes was described after X-irradiation of the exteriorized segment (3 cm) of the rat ileum with a single dose of 2200 R. A one-year follow-up was provided in rats whose exteriorized intestinal segments were irradiated. Comparisons were made between one group of animals in which the superior mesentric artery and vein were clamped during irradiation and a second group in which these vessels were not clamped. A third group of sham-irradiated controls was used for comparisons. There was a delay in the onset and progression of the radiation damage to the mucosa of the hypoxic animals in the acute post-irradiation phase. In addition, prolongation of survival in the rats with the superior mesenteric vessels clamped was observed. Mucosal regeneration was noted, occurring at 52 days post-exposure. No adenocarcinomas were found up to 354 days after irradiation. An angiofibroma and a highly differentiated osteoid lesion were described.

Adenocarcinoma↗

PubMedDate not supplied

Microfoci of avascular necrosis in sickle cell anemia: pathophysiology of the dot dash pattern.

OBJECTIVE: Definition of the nature of calcaneal "erosions" in sickle cell anemia. METHODS: Skeletons of individuals demonstrated to have had sickle cell anemia were examined for the presence of calcaneal surface discontinuity. RESULTS: Calcaneal and articular surface osseous microinfarction were identified macroscopically and confirmed radiologically by CT. CONCLUSIONS: This appears to be the first macroscopic identification of calcaneal and articular surface osseous microinfarction in sickle cell anemia and explains the osseous pathology that appears so unique to sickle cell anemia.

Anemia, Sickle Cell↗

PubMedDate not supplied

Antiquity of arthritis: spondyloarthropathy identified in the Paleocene of North America. off.

OBJECTIVE: Determination of the antiquity of spondyloarthropathy by examining the fossil record. METHODS: Fossil collections from the Paleocene and Eocene of North America were systematically examined to determine the occurrence and population frequency of spondyloarthropathy. RESULTS: Spondyloarthropathy was present in three mammalian orders dated at 30 to 50 million years. The frequency was 13% to 50% in the affected genera. CONCLUSIONS: Erosive arthritis of the spondyloarthropathy variety is now documented to have originated at least 40 million years ago in the Paleocene.

Animals↗