DNA synthesis is not required for the commitment of murine erythroleukemia cells.
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Animals↗
Biomedical subjects
J Kernen
Publications and source records attributed to J Kernen.
Control of proliferation and differentiation in cells transformed by Friend virus.
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Butyrates↗
Synchronization of MEL cell commitment with cordycepin.
The response of differentiating MEL cells to the nucleotide analogue cordycepin reveals a previously unrecognized aspect of the molecular events which cause commitment of these cells to terminal erythroid differentiation. Cordycepin rapidly inhibits commitment of DMSO-treated MEL cells in a dose range which does not cause cytotoxicity. Reversal of cordycepin treatment in the presence of inducer leads to a rapid and synchronous commitment of a significant proportion of cells in the culture. These results suggest that MEL cells can be blocked just prior to the point of commitment by cordycepin treatment.
Animals↗
Stage i well differentiated adenocarcinoma of the endometrium.
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Adenocarcinoma↗