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Biomedical subjects

J Kimmig

Publications and source records attributed to J Kimmig.

At least 19 recordsLinked to original sources
PubMed1977

[Quantitative isolation of acid mucopolysaccharides from urine in progressive scleroderma (author's transl)].

After filtration the urine was concentrated to about 1/10 of the original volume. The urine was centrifuged for 15 min at 5000 rev/min. The supernatant was chromatographed on Bio-Gel P-2-with a 10% aqueous solution of ethanol. Then the glycosaminoglycan fraction was separated into seven further fractions by chromatography on Dowex 1 X 2 and elution with increasing concentration of sodium chlorid. The desalted fractions were analysed. From the analytical data presented no definite correlation between excretion of glycosaminoglycans in urine and progressive scleroderma can be observed. These results were discussed with further data presented by Hexosamine determination.

Glycosaminoglycans↗
PubMed1976

[Histochemical investigations in scleroderma (author's transl)].

The behavior of proteoglycanes was examined by histochemical methods in excised particles of skin from patients with progressive (n = 24) and circumscribed (n = 74) scleroderma. A method described by Ishikawa was principally used. An increase of the proteoglycanes was shown preferentially in the vascular and perivascular regions in progressive scleroderma and in the interfibrous space of the connective tissue in circumscribed scleroderma. While the vascular sclerosis is prominent from the clinical point of view in progressive scleroderma, the disease processes are found in collagen connective tissue of the corium in morphea.

Adult↗
PubMed1976

[Tryptophan-load in progressive scleroderma (author's transl)].

This presentation describes effects of oral tryptophan loading (5.0 g DL) on tryptophan metabolism in healthy subjects (n = 10) and persons with progressive scleroderma. N1-methylnicotinamide (N1MN), 3-hydroxyanthranilic acid (3 HAA), kynurine (KN), tryptamin (TA), xantheurenic acid (XA) were determinated. Alterations of tryptophan metabolism were evaluated by 24 h urinary excretions of the following metabolites: 5-hydroxy indolacetic acid (5 HAA) and indole-3-acetic acid (IAA). The pathological pathways were discussed, especially the way and influence of serotonine.

3-Hydroxyanthranilic Acid↗
PubMed1976

[Metabolism of collagen in progressive scleroderma and dermatomyositis].

The biosynthesis of collagen was studied in skin of healthy subjects and patients with progressive sclerodermia and dermatomyositis. The incorporatione of radioactive precursors (14C-proline), the rate of so-called collage-like-protein in sera, and the excretion of hydroxyprolin in urine depended on the severity of the dermatomyositis in progressive sclerodermia.

Blood Proteins↗
PubMed1975

[Therapy of progressive scleroderma. Collagen-like protein in progressive scleroderma under D-penicillamine therapy].

The collagen-like-protein (CLP) in sera of patients with scleroderma (n = 20) and controls with (n = 25) this disease as well as in scleroderma-patients under treatment with D-penicillamine (DPA) was determined. The increase of collagen-like-protein roughly parallels the activity of the disease and secondly parallels the therapy. A relationship to collagen biosynthesis or metabolism is discussed.

Blood Proteins↗