Biomedical subjects
Publications and source records attributed to J Klatka.
A patient with inoperable recurrence of the larynx carcinoma in lymphatic neck system after total laryngectomy was described. Nonradical surgical treatment combined with radical radiotherapy allowed to achieve a five-year symptom-free survival in this case.
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Investigations of larynx cancer rate of Lublin population were carried out in the years 1991-1994. Factors of the community rates in each year and in five-years age group were determined. 681 suffering people were examined clinically. The clinical stage and degree of organ involvement were appointed.
The concentration of total and protein-bound hydroxyproline in the serum and total hydroxyproline in the urine was measured in the group of 52 patients with larynx carcinoma by means of Prockop's and Udenfriend's colorimetric method modified by Tomaszewski. The mean level of total and protein-bound serum hydroxyproline in the group of clinical patients was statistically significantly raised when compared with control group. The mean level of total hydroxyproline in the urine of patients with larynx carcinoma was statistically insignificantly raised when compared with control group. The degree of clinical or organic progress of larynx carcinoma was not found to influence essentially the level of hydroxyproline in the serum of the examined patients. It was shown however, that statistically essential increase in the total hydroxyproline level in the urine depends on the degree of organic progress of larynx carcinoma.
The serum concentration of total and protein-bound hydroxyproline as well as urinary hydroxyproline excretion were measured in 52 laryngeal cancer patients before, during and after irradiation. The modified colorimetric method described by Prockop and Udenfriend was used. After irradiation the increased total hydroxyproline concentration and excretion were observed, whereas no changes in serum protein-bound hydroxyproline were stated. Any correlation between the results of therapy and serum/urinary hydroxyproline levels were observed.
In 52 laryngeal cancer patients treated by radiotherapy the serum and urine level of hydroxyproline was tested in connection with the intensity of local postirradiation reactions. The serum and urine level were tested by colorimetric method of Proctor and Udenfriend in Tomaszewski modification. In patients with second and third steps of local reaction intensity there was an elevated level of hydroxyproline only in urine. No correlation was observed between the serum level and local reaction.
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