Biomedical subjects
Publications and source records attributed to J Kolarík.
Legal miniabortions were utilized for taking 106 samples of the uterine cavity contents from 83 women. The material consisted of 15 embryonic and 19 maternal tissues. The embryonic nervous tissue was discovered in 7.7% of the specimens examined. The suitability of obtaining samples for transplantation with the currently used technique of legal abortions is considered.
Transplantation of embryonic nervous tissue into the septal area of the brain in a 21-year-old female patient with schizophrenia revealed the therapeutic effect and favourable effect on memory. However, the favourable effect lasted only 6 months. Among different questions such as whether the transplant was not exhausted, or was rejected, there is the uncertainty whether we did not damage it by repeated CT examinations. We proved, however, that transplantation of embryonic nervous tissue into the brain of the recipient does not involve the danger of uncontrolled growth of the transplanted tissue. Therefore retransplantation, possibly into a different part of the brain, can be considered.
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A simple and highly efficient percutaneous method eliminating the spinal ganglion and its posterior spinal cord root in treating metameric pain is described. Monitored by X-ray the needle crosses the vertebral canal passing e.g. from the right into the left intervertebral space. The intervention itself is made by a mesocaine alcohol block. The first experience with 12 patients is favourable in postdiscotomic syndromes or lumbar and causalgic pains in lower extremities having no mechanical cause discovered by CT.
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Inspired by current knowledge of the possible participation of monoamines in the origin of schizophrenia and by experimental experience with embryonic nerve tissue transplantations, the authors ventured implantation of a human embryo's nervous tissue into a schizophrenic's brain. Six cubic millimeters of the transplant were placed in the septal area of both hemispheres. The substantial improvement of the clinical picture and, particularly, distinct improvement of memory abilities in the patient can more likely be attributed to the effect of the transplant rather than to the simultaneous mechanical intervention in the target structure of the recipient's brain.
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