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Biomedical subjects

J Korsgaard

Publications and source records attributed to J Korsgaard.

At least 37 records · Page 2Linked to original sources
PubMed1992

Comparison of two ibuprofen formulations in the treatment of shoulder tendonitis.

In order to compare the efficacy and tolerance of two drug formulations of ibuprofen, conventional tablets 600 mg QID (CI) and sustained-release tablets 1200 mg BID (SRI), a total of 147 patients in 7 centres in Denmark with nontraumatic shoulder pain were included in a double-blind dummy study. Initially all patients received a local injection of corticosteroid and local anaesthetic, and were randomly allocated either drug (CI or SRI) for a period of 3 weeks. Complete relief was recorded from significantly more of the patients in the CI group (21%) than in the SRI group (7%) while a similar number of patients improved viz., 67% of the SRI treated group and 77% of the CI treated group. Based on doctor's assessment improvement in the two groups was equal. 44% of the patients recorded side effects, the number and pattern being the same in the two groups. No serious side effects were recorded. It is concluded that the two treatment regimens can be rated as clinically equivalent.

Adult↗
PubMed1990

Pulmonary function and bronchial reactivity in asthmatics during low-level formaldehyde exposure.

This study evaluated whether formaldehyde, at concentrations similar to those found in the indoor environment, could produce adverse effects on the lower airway of 15 asthmatic persons with documented bronchial hyperresponsiveness who were exposed for 90 min in a climate chamber to clean air containing formaldehyde vapor at levels of 0.85 mg/m3, 0.12 mg/m3, and 0.008 mg/m3. No significant changes in forced expiratory volume in 1 sec (FEV1), airway resistance (Raw), specific airway resistance (SRaw), and flow-volume curves could be detected during formaldehyde exposure. Furthermore, histamine challenge tests performed immediately after formaldehyde exposure showed no evidence of changes in bronchial reactivity. No late reactions were registered during the first 14-16 hr after exposure. The results suggest that residential levels of formaldehyde are of minor importance in the emergence of pulmonary symptoms. Discrepancies between the present study and previous data may be due to differences in environmental conditions.

Adolescent↗
PubMed1990

Mite allergy and exposure to storage mites and house dust mites in farmers.

Sensitization to house dust mites, storage mites and other common inhalation allergens was studied in 144 farmers using SPT and RAST. The study population was selected from a random sample of 808 farmers and consisted of 47 persons who had declared themselves to suffer from asthma, 63 persons who had reported respiratory symptoms, and 34 healthy persons without respiratory symptoms. The most prevalent RAST was towards storage mites and was found in 17% of farmers who suffered from asthma and was estimated to occur in 5% of the random sample of farmers. A positive RAST to house dust mites was found in 17% of farmers who reported to suffer from asthma. Sensitization to pollens, animal dander and grain species was rare. A positive RAST to moulds was not found. There was a strong association between a positive RAST to house dust mites and a positive RAST to storage mites (odds ratio 21.0). A positive RAST to storage mites was significantly associated with living in a dwelling in the past which was recalled as damp (odds ratio 4.9). A high number of house dust mites was found in nearly all dwellings (median count 148 mites/0.1 g dust) and a high number of storage mites was found in some dwellings. This study suggests that in humid and temperate regions of Europe, allergy to storage mites in farmers is not caused exclusively by occupational exposure but damp housing conditions and indoor exposure to storage mites may also be important.

Agriculture↗
PubMed1990

House dust mites and atopic dermatitis. A case-control study on the significance of house dust mites as etiologic allergens in atopic dermatitis.

The occurrence of house dust mites was measured in homes of 24 patients with atopic dermatitis, 30 patients with mite-sensitive asthma and 32 patients with asthma not related to house dust mites. Patients with mite-positive asthma and patients with atopic dermatitis had significantly higher exposure to house dust mites compared with patients with mite-negative asthma. For atopic dermatitis the higher exposure to house dust mites corresponded to a relative risk of 4.7 and a clear dose-response relationship was demonstrated between exposure and risk of disease in the subgroups of patients with atopic dermatitis. The present epidemiologic results support the idea that house dust mites may be an etiologic factor in a proportion of adult patients with atopic dermatitis.

Allergens↗
PubMed1989

Atopic dermatitis and house dust mites.

The occurrence of house dust mites (Dermatophagoides spp) was investigated in the homes of 26 patients with atopic dermatitis (AD), 20 patients with psoriasis and 41 randomly selected homes in Arhus, Denmark. The AD patients with moderate to severe eczema had an increased concentration of mites (median 85 mites/0.1 g mattress dust) compared with the controls (median 8 mites/0.1 g mattress dust). The higher exposure to house dust mites corresponded to a relative risk of 4.6 and a clear dose-response relationship between exposure and disease could be demonstrated. Our results illustrate a clear association between moderate to severe atopic dermatitis and increased exposure to house dust mites in the patients' homes, and support the hypothesis that mite antigens could be an aetiological factor in atopic dermatitis.

Adolescent↗
PubMed1989

Lung function and bronchial reactivity in farmers.

The purpose of this study was to evaluate the prevalence and type of lung function disorders in Danish farmers. Three samples of farmers were drawn from a group of unselected farmers who had participated in an epidemiological study. Group I (47 persons) was a sample of the 8% of all farmers who had reported that they had asthma; group II (63 persons) was a sample of the 28% of farmers who had had wheezing, shortness of breath, or cough without phlegm; and group III (34 persons) a sample of the farmers (64% of the total) who had no asthma and no respiratory symptoms. The farmers with symptoms (groups I and II) had low mean levels of FEV1 and high values for residual volume, whereas the symptomless farmers had normal lung function and no airways obstruction. The proportion of farmers with an FEV1 below the 95% confidence limit for predicted values was 43% in group I and 23% in group II; there were none in group III. Bronchial hyperreactivity to histamine occurred in 96% of asthmatic farmers, 67% of farmers with wheezing or shortness of breath, and 59% of symptomless farmers. A low level of FEV1 was associated with the number of years in pig farming and bronchial hyperreactivity in group II but not group I or III. Most of the bronchial hyperreactivity was explained in the multiple regression analysis by a low FEV1, though this was significant only for farmers in group II. Thus farmers who reported asthma, wheezing, shortness of breath, or a dry cough in general had airways obstruction with an increased residual volume, whereas symptomless farmers had normal lung function. Severe bronchial hyperreactivity was mostly explained by a diagnosis of asthma and poor lung function, though some farmers with normal lung function and no respiratory symptoms had increased bronchial reactivity.

Adult↗
PubMed1988

Control of house dust mites by electrical heating blankets.

The contents of house dust mites, Dermatophagoides (D), in 10 beds supplied with electrical heating blankets (EHBs) and in 10 control beds were followed for 1 year. All beds were in regular use during the study period. Dust from mattresses and EHBs was collected monthly and analyzed for D by microscopy. Blankets were turned on during daytime and were washed every 3 months. For each bed the median concentration of D during the entire period was related to initial value. In the beds supplied with blankets, the overall median was 52% compared to 122% in the control beds (p less than 0.05). The difference between the two groups of beds was observed within the first month. Major antigens from D were reduced to 32% in the beds supplied with blankets and increased to 120% in the control beds (p less than 0.05). Climatic conditions were measured beneath the blanket in a spare bed. When beds were covered by eiderdown, temperature was increased by 26 degrees C, and the relative humidity was decreased by 24% within 3 hours. In conclusion, EHBs appear capable of reducing relative humidity and concentration of house dust mites on mattress surfaces.

Allergens↗
PubMed1988

Respiratory symptoms in Danish farmers: an epidemiological study of risk factors.

An epidemiological study was performed with a self administered questionnaire in a representative sample of 1685 Danish farmers. The purpose of the study was to assess the prevalence of self reported asthma, wheezing during work, and symptoms of chronic bronchitis and to evaluate possible risk factors for the development of these symptoms. A response rate of 73.3% was obtained. The prevalence of asthma was 7.7% and of chronic bronchitis 23.6% in responders. The prevalence of asthma and chronic bronchitis increased from 3.6% and 17.9% in 31-50 year old farmers to 11.8% and 33.0% in 51-70 year old farmers, and from 5.5% and 17.5% in dairy farmers to 10.9% and 32.0% in pig farmers. A logistic regression analysis with correction for age and smoking habits confirmed that pig farming was a risk factor for asthma (odds ratio 2.03), chronic bronchitis (odds ratio 1.53), and wheezing during work (odds ratio 3.33).

Adult↗
PubMed1983

Sensitivity to house dust mite and grass pollen in adults. Influence of the month of birth.

A comparison was made between the birth month of a control population and a sample of 240 adult patients with bronchial asthma or rhinitis and positive skin test towards house dust mite (Dermatophagoides pteronyssinus). The patients were born more frequently (P less than 0.005) in the summer and autumn months than in the other seasons. A similar comparison of 336 allergic patients with a positive skin test towards grass pollen (Phleum pratense) but no consistent seasonal preference in the birth months was revealed. This was possibly explained by the age of the patient group studied. The increased incidence of house-dust mite allergy in patients born in the months of May to September inclusive when house dust mites are supposed to be most abundant corresponds to a relative risk of 1.44. It is important to diminish the exposure to house dust mites in early childhood because exposure to allergens may influence the development of allergic disease in later life.

Adult↗
PubMed1983

House-dust mites and absolute indoor humidity.

The concentration of house-dust mites (Dermatophagoides spp.) was investigated for four seasons in three locations in each of 50 Danish apartments. Simultaneously the absolute humidity was recorded and the previously known correlation between mite counts and indoor humidity was confirmed. It appeared, however, that apartments which had a low absolute indoor humidity in the winter period (due to low household load of water vapour) did not contain noticeable concentrations of house-dust mites in the summer and autumn despite the fact that the indoor absolute humidity in these apartments could be high enough to allow for a high peak-population of mites. Because of this it is suggested that in a temperate climate avoidance measures against house-dust mites should be supplemented at least by a drying out period in the winter, when this process is convenient to perform because of the low outdoor absolute humidity.

Animals↗