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Biomedical subjects

J Korsgaard

Publications and source records attributed to J Korsgaard.

48 records · Page 3Linked to original sources
PubMed1983

Preventive measures in mite asthma. A controlled trial.

To evaluate the effect of preventive measures 46 patients, all allergic to house-dust mites (Dermatophagoides spp.), were randomly allocated to a study and a control group. According to the patients' subjective recordings of symptom score and use of medicine, compared with the control group, the study group had improved. There was, however, no improvement when comparing the objective recordings of morning and evening peak flow and use of medicine, and it is concluded that the preventive measures in this programme are not very effective for patients allergic to house-dust mites. The reduction in indoor humidity in the study group was limited and, as a high indoor humidity is the cause of huge populations of house-dust mites in homes, it is emphasized that future programmes of preventive measures should focus more on damp problems, particularly those related to bad housing construction.

Adolescent↗
PubMed1983

Mite asthma and residency. A case-control study on the impact of exposure to house-dust mites in dwellings.

The occurrence of mites in house dust from the homes of 25 patients with newly diagnosed house-dust mite asthma was much greater than that in the house dust from homes of 75 randomly selected matched control subjects. The difference in exposure corresponded to a relative risk of about 7.0, and a clear dose-response relationship could be demonstrated. The 25 patients lived in older and more humid houses than the control subjects did, which explains the greater number of house-dust mites found and suggests possibilities for and the necessity of introducing hygienic standards for the indoor environment as a measure of primary prevention in house-dust mite allergy.

Allergens↗
PubMed1982

Preventive measures in house-dust allergy.

To evaluate the effect of preventive measures on the concentration of house-dust mites (Pyroglyphidae), the homes of 23 consecutive patients allergic to house-dust mites and the homes of 75 randomly selected control subjects were studied. Although the patients' homes were cleaned more frequently (p less than 0.0007 for 4 cleaning qualities), greater concentrations of house-dust mites (p = 0.0073) were found in dust from bedroom carpets in the patients' homes than in the homes of the control subjects. A tendency (p less than 0.15) in the same direction was found for mattress surfaces and living room carpets. High absolute humidity of indoor air was related to greater concentrations of house-dust mites. There was a tendency (p less than 0.10) towards higher humidity in the patients' homes than in those of the control subjects. It was concluded that high humidity improves the survival of house-dust mites in homes. Energy saving measures such as installing insulation raises indoor humidity and can lead to an increased incidence and severity of house-dust mite allergy.

Animals↗
PubMed1979

Tarsonemid mites in Danish house dust.

From a study of 98 typical Danish city apartments it was found that pyroglyphid and tarsonemid mites dominated the housedust acarofauna. Both groups of mites show a remarkable similarity in their occurrence and dependence on the microclimate. Room air humidities above 7 g water/kg dry air involved the highest densities. Below this limit only background contamination appeared. At least 14 distinct forms of tarsonemid mites were found, with Tarsonemus floricolus Can. & Fanz., 1876 as the dominating species. As tarsonemid mites were found regularly rather than occasionally, it is suggested that these mites may be responsible for at least a part of the cases of housedust allergy that cannot be ascribed to the content of Dermatophagoides mites in the housedust.

Allergens↗
PubMed1979

Detection and quantitation of Dermatophagoides antigens in house dust by immunochemical techniques.

Rabbit antibodies against D. pteronyssinus whole culture extract were rendered specific to mite antigens by immunoabsorption with extract of human dander. Using the absorbed antibodies, an extract of a mite culture gave rise to 15 peaks in crossed immunoelectrophoresis and to a titer of 512 in counter-immunoelectrophoresis. When applied to dust samples from the homes of allergic patients, counterimmunoelectrophoresis gave reproducible results within an error of 1 titer-step. Mite antigens were detected in 64% of 105 dust samples investigated. The titer correlated well (P less than 0.005) with the concentration of Dermatophagoides bodies, found in 13 mattress dust samples by microscopy. Advantages and limitations of immunochemical quantitations of house dust mites in dust samples is discussed in relation to investigations by microscopy.

Antibodies↗
PubMedDate not supplied

A one-year case study of farmers with storage mite allergy.

Four farmers with a positive bronchial challenge test to either L. destructor or T. putrescentiae had bronchial histamine challenge every second month during a year. In the same year, monthly samples of house dust, grain, straw and hay were analyzed for their content of house dust mites and storage mites. The exposure to house dust mites and storage mites differed between farmers. Significant changes in histamine reactivity were found, but no association with time of year or mite counts was observed.

Agriculture↗
PubMedDate not supplied

Storage mites as a cause of bronchial asthma in Denmark.

From October 1982 to July 1983, 133 consecutive patients complaining of allergic symptoms were prick-tested with three storage mites (Acarus siro, Lepidoglyphus destructor, Tyrophagus putrescentiae) and two housedust mites (Dermatophagoides pteronyssinus and Dermatophagoides farinae). A total of 60 patients (45%) had a positive prick-test for one or more of the storage mites. A mutual positive correlation was found between the prick-test results for the two house-dust mites as well as for the three storage mites. No significant correlation was found between house-dust mites and storage mites. Four cases of allergy to storage mites are presented. The diagnosis of storage mite allergy was based on the clinical history, prick-test, bronchial provocation test and the finding of storage mites in the environment of the patient. Our study suggests that allergies to storage mites could be rather frequent in the Danish population.

Adult↗
PubMedDate not supplied

Annual fluctuations of mites and fungi in Danish house-dust: an example.

For one year dust was sampled monthly from a single mattress. Until August mite counts were at background levels. In September and October there was a burst in the counts for the house-dust mite, Dermatophagoides farinae and for the house mite, Glycyphagus domesticus. Their occurrence might be interpreted as a response to large densities of an unidentified yeast in September. This yeast appeared when the indoor absolute humidity exceeded 9 g H2O/kg dry air. The mite Tarsonemus rakowiensis reached its maximum in October, and might be a possible house-dust mite predator, although the evidence is far from conclusive. An aliquot of ten grams of mattress dust sampled from a mite-free location on top of the mattress hardly became infested, although the environmental conditions were ideal. Obviously, the mattress dust from the dry room was not optimal for either the yeast or the mites.

Animals↗