Biomedical subjects
Publications and source records attributed to J Kossakowski.
The preparation of N-substituted cyclic imides N-[4-[(4-aryl)-1-piperazinyl]alkyl]-5,7-dioxabicyclo[2.2.2]octane- 2, 3-dicarboximides by condensation of N-(3-chloropropyl)- or N-(4-chlorobutyl)imides with appropriate amine has been described. One of compounds was tested in the Vogel's test and displayed an expected activity on CNS.
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In continuation of the development of antipsychotic and anxiolytic agents with a reduced propensity toward extrapyramidal side-effects, a series of N-aminoalkyl derivatives of (s)-(+)-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-(10H, 11aH)-dione was prepared. Evaluation of these compounds in revealed a very low affinity for 5-HT1A receptor.
Preparation of a number of derivatives of 1-methyl-5-oxobicyclo[2.2.1]heptane-2,3-dicarboximide with a potential anxiolytic activity has been described. New analogs of Tandospirone i.e. derivatives of bicyclo[2.2.1]heptane (10), were aimed at.