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Biomedical subjects

J Kuś

Publications and source records attributed to J Kuś.

At least 55 records · Page 3Linked to original sources
PubMed1997

[Immunomodulatory properties of therapeutic and subtherapeutic levels of theophylline: effect on metabolic activity of human monocytes].

The aim of present study was to analyze the potential immunomodulatory effects of theophylline. We studied the influence of therapeutic and subtherapeutic drug concentrations on the metabolic human monocytes activity using the chemiluminescence test, that allows to evaluate the production of free oxygen radicals. Subtherapeutic theophylline concentrations of 2.5 and 5 micrograms/ml significantly increased monocytes spontaneous chemiluminescence activity. Moreover, in concentrations 5-20 micrograms/ml theophylline interfered with the process of monocyte activation by zymosan: decreasing O2-total and maximal production as well as affecting duration of the "respiratory burst" reaction. Correlation between theophylline concentration and intensity of its suppressive effect was also observed. Therefore we concluded that theophylline might be useful in the treatment of allergic inflammation characterising bronchial asthma.

Adjuvants, Immunologic↗
PubMed1997

[Theophylline does not exert an effect on the early phase of TNF-alpha through the activity of human monocytes].

Tumor necrosis factor-alpha (TNF-alpha) is commonly recognized as a one of the most important mediators of allergic inflammation and hyperreactivity in bronchial asthma. Several studies proved the inhibitory effect of theophylline (including it's subtherapeutic doses) on the synthesis of TNF-alpha in 24 hrs monocyte cultures. The aim of our study was to determine the influence of therapeutic and subtherapeutic concentrations of the drug on the early phase of TNF-alpha release. We showed that theophylline did not significantly alter the cytokine concentration measured by Elisa method in supernatants from 2 hrs monocyte cultures stimulated by LPS (1 microgram/ml). Therefore, we concluded that the mechanism of theophylline inhibitory action on TNF-alpha production is more likely associated with changes in genome expression, than with the inhibition of the cytokine liberation from the cell.

Humans↗
PubMed1997

[Reasons for chronic expectoration--case reports].

To illustrate reasons for chronic culture positive pulmonary tuberculosis 4 patients are presented. In two cases the reasons for treatment failure were on the doctors' side. In one case a doctor used an insufficient number of drugs, in the second case the treatment was too short. In the third case there were more than one reason for treatment failure: the patients' poor compliance, and the doctors' fault: an inadequate choice of drugs. In the last case adverse reactions to drugs caused the treatment failure.

Adult↗
PubMed1997

[Surgical treatment of patients with multi-resistant pulmonary tuberculosis--case reports].

Two patients with multidrug-resistant pulmonary tuberculosis were surgically treated after 3 and 7 years of unsuccessful chemotherapy. There was pneumonectomy in one case and lobectomy with segmentectomy in the second. Pneumonectomy was complicated by bronchopleural fistula. Both patients become sputum culture negative after surgical treatment but first patient died 5 months after surgery because of acute hepatitis.

Adult↗
PubMed1997

[Lung and pleural changes caused by exposure to asbestos].

Asbestos exposure results in an increased risk of nonmalignant as well as of malignant pulmonary and pleural disease. The asbestos-related disease are inexorably progressive (cancer) or insidious (fibrosis), untreatable and widespread in the industrialized and urban world. The identification of these diseases is important because therapy and prognosis differ from the other pulmonary fibrosis. The case reports indicate that careful clinical and histologic examination allows proper diagnosis. Two patients with asbestos-related disease after asbestos exposure are described.

Asbestos↗
PubMed1997

[Evaluation of angiogenic activity in sera from patients with interstitial lung diseases].

Angiogenesis is a process of new blood vessels' formation occurring in many physiological and pathological conditions. Neovascularisation is the principal vascular response in chronic inflammation and concomitant fibrotic process. Microvascular changes in various organ sites in sarcoidosis (BBS) and some of the symptoms of the disease may be related to microangiopathy. Moreover, vascular alterations were also observed in lung specimens from idiopathic pulmonary fibrosis (IPF) and avian fanciers lung (AFL) patients. The present study was aimed at testing the effects of serum from 43 patients with ILD (24 BBS, 8 AFL, 8 IPF, 3 DIPF--drug induced pulmonary fibrosis) and 11 healthy controls on angiogenic capability of normal blood peripheral mononuclear cells (PBMC) in the murine intradermal angiogenesis assay (according to Sidky and Auerbach). The data demonstrated that sera from ILD patients significantly enhanced angiogenic capacity of normal PBMC as compared to control sera (p < 0.001). The effect was more pronounced for AFL patients than for BBS and IPF ones (p < 0.05). Sera from DIPF did not stimulate angiogenesis compared to control sera. The data showed that sera from ILD patients constitute sources of mediators participating in angiogenesis. This phenomenon may play role in pathogenesis of chronic immunological processes in lung.

Adult↗
PubMed1996

[Tuberculosis of the bones and joints].

The incidence of tuberculosis has increased over the last several years. Bones and joints tuberculosis makes 20% of all extrapulmonary locations of tuberculosis. In Poland this form of tuberculosis is underdiagnosed. We present three cases with tuberculosis of bones, joints and lung to remind the basic principles of diagnosis and treatment.

Aged↗
PubMed1995

[Initial experience with a new type of high energy neodymium laser in correcting stenosis of the airway].

The aim of the study was to assess the use of a new Nd:YAG laser--mediLas fibertom--in correcting malignant and benign stenoses of the airways. Eighteen patients were included in the study. In 9 these were caused by malignant tumors, in 3 by nonmalignant tumors, in 6 by post-inflammatory stenoses of the airways. Altogether 99 laser sessions were carried out. In patients with malignant diseases complete recanalization was achieved in 6 patients, in 2 partial. One patients did not benefit form the laser procedure. In patients with benign tumors complete recanalization was achieved in all of the patients. In 5 out of 6 patients the post inflammatory stenosis was corrected. Satisfactory results observed after the second, fourth and one year after the initial laser procedure encourage to use this from of therapy in cases of malignant and nonmalignant narrowing of the airways.

Adolescent↗
PubMed1994

[Pulmonary changes as a result of pulmonary artery involvement during Takayasu disease--case report].

We described a case of Takayasu disease with pulmonary artery involvement in a young woman with dyspnea, and multiple pulmonary infiltrations on chest radiogram. The changes were initially diagnosed and treated as protracted pneumonia. In the later stage of the disease the development of the typical inflammatory changes in the systemic arteries with absence of the left radial pulse suggested the diagnosis.

Adult↗
PubMed1992

[Results of 3-stage treatment: (I) corticotherapy, (II) linear acceleration and (III) orbital decompression in 206 patients with malignant Graves ophthalmopathy].

There is no, so far, a rational method of therapy based upon the etiology of autoimmune Graves' ophthalmopathy. As a malignant Graves' ophthalmopathy we defined the most severe eye changes leading to the sight loss or permanent disability of vision which are classified as exceeded class 3c according to the eye changes classification of the American Thyroid Association [27]. The aim of the study was to develop the most efficacious method of therapy for malignant Graves' ophthalmopathy. The material consisted of 206 patients treated according to the 3-stage method: 1-st--corticotherapy, 2-nd--radiotherapy, including linear accelerator, 3-rd--orbital decompression. Moreover, in four patients plasmapheresis was applied and in additional five cyclosporine was administered. In all 206 patients the estimation of the results of the treatment was based on the Donaldson ophthalmopathy index [4]. It has been proved that corticotherapy combined with linear accelerator radiotherapy has been the most efficacious method of treatment. It has also the least number of side effects. Orbital decompression as the 3-rd stage of treatment was employed in those cases in which the previous two stages of medical therapy were unsuccessful.

Adrenal Cortex Hormones↗
PubMed1991

Ultrastructural study of human macrophages from peritoneal dialysate.

Peritoneal macrophages obtained from 30 patients with end-stage kidney treated by intermittent peritoneal dialysis and from 30 subjects with normal renal function (relative control) were investigated by light microscopy, transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Two populations of peritoneal macrophages were distinguished in both dialysed and control patients. In the former group, the main population consisted of macrophages similar to monocytes from peripheral blood, while the majority of macrophages in control patients showed larger size, more prominent vacuolization of the cytoplasm and stronger spreading on glass surface.

Adolescent↗
PubMed1990

[Lymphoid interstitial pneumonia].

Interstitial lymphoid pneumonia is a rare disease characterized by diffuse infiltration of lung tissue by lymphocytes and plasmocytes. The diagnosis can be only achieved by histopathological examination of the biopsied pulmonary tissue. It should be differentiated from malignant processes of the lymphatic system. Immunosuppression is the main line therapy, with prednisone, azatioprine and cyclophosphamide.

Aged↗