Biomedical subjects
Publications and source records attributed to J Kuś.
In scanning microscopy the right tonsil melanoma was examined. The authors stressed the usefulness of this examinations in precise diagnose of above mentioned tumor along with the routine histopathologic examination.
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We examined by use of scanning microscopy the healthy looking tracheal mucous membrane 25 mm from the cancer lesions. The small pieces were taken during the initial routine tracheostomy before the laryngectomy. In 21 examined patients there was one woman. One patient did not smoke tobacco and did not drink alcohol. 19 were farmers and workers. Two had other professions. The normal tracheal mucous membranes were found in 6 patients, 2 of them were farm workers. In the remaining group there were abnormal appearance of cilia or complete lack of them, being replaced by the plain epithelium layer. In one case after cobalt therapy the mucous membrane was completely destroyed.
A comparison of serum, pulmonary tissue and bronchial secretory levels of erythromycin and cyclic--11,12 carbonate of erythromycin (Davercin--Polfa) was carried out in 55 patients with lung cancer. All patients received erythromycin and Davercin 80 hours prior surgery, during which a small fragment of pulmonary tissue was removed for further evaluation. Concentration of both antibiotics was determined microbiologically. Better penetration of Davercin to the pulmonary tissue was found, as well as higher tissue concentration. The study demonstrates the advantage of Davercin over erythromycin in treating bacterial infections of the respiratory system.
A case of common variable immunodeficiency in a patient with recurrent respiratory bacterial infections is presented. The patient was successfully treated with fresh frozen serum. The authors discussed different models of substitution therapy in primary antibody deficiency.
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Human larynges, removed surgically for advanced planoepithelial carcinoma were used for study. After employing appropriate preparation procedure the obtained material was examined in scanning electron microscope (SEM). The predominant findings were: the human cancer cells transmigrate through the venule lining at/or near the sites of the endothelial intercellular junction, capillaries and postcapillary venules constitute a territory within the transmigration of lymphocytes, piercing the body of the endothelial cell, occur in both directions, the cellular elements of the immune system are relatively more numerous gathered in the peripheral areas of the primary tumor, the obtained results are consistent with in vivo and in vitro experimental data.
Observations that certain primary tumors (solid ones) are infiltrated by cells which participate in immune responses tend us to examine this problem in spontaneously growing larynx carcinoma (ca. planoepitheliale). Our observations in SEM revealed within but also in surrounding of cancer infiltrations the presence of cellular elements belonging to the immune system like: lymphocytes, monocytes and macrophages. The most numerous of them, lymphocytes, are brought to the surrounding and tumor's territory by very rich vascular network (angiogenesis phenomenon). Bidirectional transmigration of the lymphocytes, observed mainly within the postcapillary venules, takes place through the cytoplasm of endothelial cells. It is most probably that they are lymphocytes of T-type which are involved in a cell mediated mechanisms of the immune response against a tumor. The lymphocytes are responsible also for the presence of monocytes and especially macrophages within a tumor's territory. These facts suggest that the human organism, in certain degree, is able to fight against malignant tissue by similar mechanisms which are involved in the rejection of the graft.
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Morphology of blood vessels in cancer of the larynx, which as other solid tumors has great neoangiogenic abilities, was studied on microcorrosion casts in SEM. Most evident changes of the endothelial patterns were seen on the casts of capillaries, venules, and veins. Capillaries, especially the newly formed, are the most numerous constituent of the vascular bed in all zones of cancer of the larynx. These vessels exhibit great morphological differentiation varying from the single, blind-ended pipes via relatively long hairpin loops spirally twisted in the long axis, to strongly spiralled and convoluted loops, resembling pseudoglomeruli. The newly formed capillaries deriving predominantly from the host's capillaries, venules, and veins have a embryonal character. It seems reasonable to presume that the neoangiogenesis process triggered by active influence of the tumor angiogenesis factor, is in principle, a repetition of the mechanism of the embryonal angiogenesis.
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In view of a considerable increase of the tracheal injuries brought about by intubation, further detailed information on microcirculation of the trachea is needed. For this purpose, the normal microvascularization of the guinea pig trachea was investigated in microcorrosion casts viewed in a scanning electron microscope. The trachea is supplied by longitudinal vascular bundles running at both sides of the organ, including both longitudinal tracheoesophageal arteries and veins. They are the source of a segmental vascularization of the trachea. Due to numerous arteriovenous anastomoses and anastomoses occurring within respective arterious and venous vascular systems, a constant blood flow within submucous capillary plexus and the tracheal wall is provided. A characteristic feature of tracheal vascularization is a very rich, dense network of veins, which form well-developed plexuses, particularly in tracheal segments covered by skeletal cartilages.