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J L MELNICK

Publications and source records attributed to J L MELNICK.

At least 91 records · Page 5Linked to original sources
PubMed1962

Thermal inactivation of poliovirus under anaerobic conditions.

Wallis, Craig (Baylor University, Houston, Texas) and Joseph L. Melnick. Thermal inactivation of poliovirus under anaerobic conditions. J. Bacteriol. 84:389-392. 1962.-Of the six strains of poliovirus tested (three antigenic types), none was stabilized at 50 C under anaerobic conditions. The previously reported stabilization of polioviruses using thioglycolate had been attributed to anaerobic conditions. However, the sparing effect attained with high concentrations of thioglycolate was achieved as readily with other organic salts (benzoate, acetate) which could not be attributed to the anaerobic state. The viruses failed to be stabilized when low oxygen tension was obtained by dilute thioglycolate, l-cysteine, and nitrogen.

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PubMed1961

Rapid development of drug-resistant mutants of poliovirus.

Guanidine hydrochloride is a potent inhibitor of poliovirus synthesis in cell culture. However, the viral progeny which do grow in the presence of guani-dine may become approximately 10,000 times more resistant to the drug. The phenomenon of drug resistance poses yet another problem in the search for a satisfactory viral chemotherapeutic agent.

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