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Biomedical subjects

J Larrauri

Publications and source records attributed to J Larrauri.

At least 37 records · Page 2Linked to original sources
PubMed1992

Helicobacter pylori infection in children: clinical, endoscopic, and histologic correlations.

We have assessed 270 consecutive patients (age range 0.8-20 years) referred for endoscopic study because of abdominal pain during 32 months. Helicobacter pylori (HP) was detected by culture in 91 cases (33.7%). HP colonization increased significantly with age (p less than 0.01). Nine patients less than 5 years of age were colonized by HP. A previous history of peptic ulcer disease in first-degree relatives was significantly more frequent in the HP-positive group (p less than 0.001). The frequency of HP positiveness as related to diagnosis was: normal, 3.3%; nonactive chronic gastritis, 100%; active chronic gastritis, 97.2%; gastric ulcer, 75%; and duodenal ulcer, 90.9% (p less than 0.001). Endoscopic nodular antritis was a frequent (67%) and specific finding; this presence was associated with that of lymphoid follicles in the histopathological study. Signs of histological activity were observed in 55.9% of the HP-positive patients. The histological colonization by HP was assessed semiquantitatively, and a significantly greater HP colonization score was observed in patients with signs of histological activity (p less than 0.001). A significant correlation was found between HP colonization score and histological score (rs = 0.574), with a significant association between the degree of HP colonization and the histologic categories (p less than 0.001). The present study suggests a pathogenic role of HP in the development of gastroduodenal disease in children.

Adolescent↗
PubMed1991

Glandular odontogenic cyst: clinicopathologic analysis of three cases.

The glandular odontogenic cyst is a rare cyst of odontogenic origin, first described in 1988 by Gardner et al. Three previously unreported glandular odontogenic cysts are presented; none recurred after the initial surgical treatment, and one example was associated with a squamous odontogenic tumor-like proliferation in the wall. Ten similar cases were found in the literature, and their clinical and roentgenographic features, and follow-up, have been compared with the present cases.

Adult↗
PubMed1991

[Histopathology of biliary atresia: correlation with biliary flow].

The objective of KASAI's operation is to obtain a postoperative bile excretion and to maintain an internal biliary fistula. The purpose of this report is to study the relationship between the liver histopathology and the postoperative bile flow and survival. From july 1976 to january 1990, 66 patients underwent a corrective operation for biliary atresia. In 24 patients we performed a KASAI's operation with internalization of the biliary conduit, 36 with externalization, four gall-bladder KASAI and two liver biopsy. The mean age at operation was 66 days and postoperative bile excretion was obtained in 43 of them (66 per 100). The survival rate was 70 per 100. The liver histopathology shown: minimum portal fibrosis (7.8 per 100), moderate (49 per 100) and severe (43 per 100). We found bile ducts in 30 patients (46 per 100), in three bile ducts were less than 50 mu, in 15 between 50 and 100 mu and more than 100 mu in 12. We did not found statistic correlation between grade of liver fibrosis size of bile duct and postoperative flow. We found a statistic correlation between the presence of bile ducts and postoperative flow (p less than 0.05).

Anastomosis, Surgical↗
PubMed1990

Gastric heterotopy of the biliary tract.

The case of a 12-year-old girl having cholestatic syndrome, due to the presence of gastric tissue in the gallbladder and extrahepatic biliary tract, is reported here.

Bile Duct Neoplasms↗
PubMed1990

Association of juvenile and adenomatous polyposis with pulmonary arteriovenous malformation and hypertrophic osteoarthropathy.

The juvenile form is the usual type of colonic polyp seen during childhood. However, mixed forms associating juvenile and adenomatous polyps have been reported. A syndrome including the association of generalized juvenile polyposis, pulmonary arteriovenous malformation, and hypertrophic osteoarthropathy has been described in three cases; however, this is the first report of the association of mixed juvenile and adenomatous polyposis, pulmonary arteriovenous malformation, and hypertrophic osteoarthropathy.

Animals↗
PubMed1990

[Arteriovenous fistula of the cecum diagnosed by digital angiography].

We report the case of a 69 year-old female, with cardiac disease, hypertension, and chronic renal failure treated by hemodialysis; she had several episodes of gastrointestinal hemorrhage, which could not be diagnosed by conventional methods. Digital angiographic study demonstrated the exact cause: it allowed to localize an arterio-venous malformation. A right hemicolectomy was performed and the pathologic study showed the presence of an arteriovenous fistula. Three years later the patient is free of symptoms. We recommend digital angiography in cases of gastrointestinal hemorrhage of unknown or unclear etiology, particularly in patients in chronic renal failure, on the basis of the association of hemodialysis and arteriovenous malformation.

Aged↗
PubMed1988

[Congenital hepatic fibrosis: apropos of 12 cases].

Twelve patients with congenital hepatic fibrosis have been retrospectively studied and followed for 1 to 14 years. Clinical features, hepatic function tests and biopsy have been analyzed. Presence of portal hypertension and congenital malformation have been investigated. Clinical presentations varies from newborn to nine years of age without male or female predominance. Most frequent clinical form has been hypertensive type. Cholangitic type has worse prognosis. Familiar recurrence rate is 20%. Congenital malformations are associated in 92% most frequently infantile polycystic kidney disease. Hepatic biopsy has confirmed diagnosis in all patients.

Child↗
PubMed1987

Effect of gluten supplementation in healthy siblings of children with celiac disease.

The clinical, functional, and histopathological effects of 18 g additional gluten intake daily for 4 wk was studied in 13 healthy siblings of Spanish children with celiac disease, including two pairs of discordant monozygotic twins. Five of the 13 children were HLA-DR identical to the celiac sibling, 5 shared only one HLA-DR antigen with the celiac sibling, and 3 had completely different HLA-DR antigens than their respective celiac brothers or sisters. Clinical evaluation and functional tests (routine blood, xylose absorption, and fecal fat excretion studies) were performed before, during, and after gluten challenge. A jejunal biopsy specimen was taken at the end of the 4-wk period of gluten supplementation. No clinical abnormalities were found during the period of the study and there was no significant decrease of xylose absorption. Fecal fat excretion studies gave normal results, both before and after gluten challenge. The high gluten diet did not lead to histopathologic abnormalities in any of the jejunal biopsy specimens, which showed a normal range of crypt to villus ratio and surface-cell height. The present results do not support the view that excessive gluten intake is toxic for individuals who are genetically predisposed but do not have overt celiac disease. The findings also suggest that other factors besides HLA-DR antigens and gluten intake are important for expression of the disease.

Biopsy↗
PubMed1987

[Digestive leiomyomas in childhood].

Leiomyoma is a very rare tumor, originating in smooth muscle. During the last 18 year authors treated four of them from 159 digestive tumors. This were located in jejunoileal bowel with occlusion in two cases and bleeding problems in the other two.

Child, Preschool↗
PubMed1986

[Hepatic lesions caused by alpha 1-antitrypsin deficiency in childhood. Review of 14 cases].

Fourteen cases of alpha-1-antitrypsin deficiency are presented. All of them had a PIZZ phenotype except two in which a PIMZ phenotype was found. It must be pointed out that histological findings show a great variability among the different patients most of which did not have intracellular PAS-positive amylase inclusions in liver biopsy specimens. Clinical course did not correlate with either the age of onset of the disease or the phenotype found, thus indicating that other additional factors are involved in determining prognosis. We insist on the importance of a careful study of all neonatal hepatitis syndromes in order to rule out a alpha-1-antitrypsin deficiency.

Biopsy↗
PubMed1986

[Anderson's disease. Apropos of a new case].

A new case of Anderson's disease in a 3-month-old black female infant is presented. This diagnosis should be considered in infants with chronic diarrhoea, fatty stools, failure to gain weight which may be present from birth, low serum cholesterol concentration (less than 70 mg/ml), low plasma triglyceride levels, and hypobetalipoproteinaemia. However, suspicion of diagnosis clinically can be certainly verified by intestinal biopsy showing characteristic epithelial cell pattern. Steatorrhoea may be effectively treated by substituting medium for long-chain triglycerides in the diet. This disorder needs to be distinguished from familial hypobetalipoproteinaemia as well as abetalipoproteinaemia, and it prognosis is good, because of absence of acanthocytosis, neurological involvement and ocular lesions.

Abetalipoproteinemia↗