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Biomedical subjects

J Larrauri

Publications and source records attributed to J Larrauri.

54 records · Page 3Linked to original sources

[Kniest's syndrome. Two cases with psychomotor retardation (author's transl)].

Two cases are presented, a female and a male, with a clinical and radiological picture which can be included in Kniest's syndrome. Both patients showed significant psychomotor retardation. The boy presented bilateral glaucoma. The osseous biopsy of the girl showed many large sized chondrocytes in the cartilagenous tissue surrounded by clear lacunae and immersed in a loose matrix giving them the appearance of Swiss cheese.

Bone and Bones↗

Fibrous histiocytoma of the lung.

A case of asymptomatic fibrous histiocytoma of the lung is described in a 14-year-old girl. A left thoracotomy was performed followed by partial resection of the lingula. Postoperative progress was uneventful.

Adolescent↗

[Cost-benefit analysis of the anatomo-pathological study of tonsillectomy specimens in the pediatric population].

To study the cost-benefit of the histological examination of tonsilar samples, we evaluated 567 cases (547 routine and 20 nonroutine cases) of patients under 14 years of age, operated between 1st January 1996 and 30th November 2000. There were 2 routine cases (0.3%), and 6 nonroutine cases (30%) with a diagnosis different to follicular hyperplasia. In this way, our clinical preoperative sensitivity was 75% and specificity 97%. The average cost per case at our Centro to study the tonsilar samples was 30$. We conclude that the histological examination of tonsilar specimens is economically worth only in nonroutine cases, although additional factors (e.g. training of residents of Pathology and the quality control of the institution must be taken into consideration.

Adolescent↗

Immunohistochemical expression of p53, Bcl-2, COX-2, C-erb-B2, EPO-R, beta-catenin, and E-cadherin in non tumoral gastric mucous membrane.

Different authors have investigated the immunohistochemical expression of some proteins in the adenocarcinoma of the stomach, including cell cycle regulators proteins like p53 and Bcl-2; growth factors (c-erb-B2 and EPO-R); angiogenesis-related markers such as COX-2 and cellular adhesion molecules (beta-catenin and E-cadherin). While these proteins have been studied in gastric adenocarcinoma, their immunophenotyping in non tumoral gastric mucous membrane remains unexplored. In the present study, we investigated the expression, function and behavior of these proteins in normal gastric mucous membrane to contribute to gain further knowledge on the significance of their loss or overexpression in malignant gastric tumors.

Biomarkers↗