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Biomedical subjects

J Linde

Publications and source records attributed to J Linde.

29 records · Page 2Linked to original sources
PubMed1977

Diabetes and hypoglycemia in chronic pancreatitis.

Fifty-nine patients with chronic pancreatitis were studied in retrospect. The incidence of overt diabetes was high, 36/59. Half of the diabetics were insulin-dependent, and among these labile diabetes with hyperglycemia and high amounts of glucose in the urine was not uncommon. Hypoglycemic episodes were noted in 14 of the 18 insulin-treated patients, and in 3 patients severe hypoglycemia was believed to be the cause of death. Mechanisms leading to such disastrous hypoglycemia are discussed, and a hypothesis regarding lack of glucagon as the cause of severe hypoglycemic attacks was experimentally tested by measuring pancreatic glucagon in plasma in two patients with pancreatic diabetes and severe brain damage following hypoglycemic coma. Low basal glucagon values were found, and the normal rise upon insulin-induced hypoglycemia was not seen. From these results it may be justified to suggest, firstly that glucagon should be used in the management of severe hypoglycemia in chronic pancreatitis, and secondly that a certain degree of hyperglycemia should be allowed in the treatment of diabetes in these patients.

Adolescent↗
PubMedDate not supplied

[Carcinoid--advances in diagnosis and treatment].

Carcinoid is one of the most frequently diagnosed neuroendocrine tumours. It develops slowly but grows by infiltration and has the ability to give metastases in distant organs. The clinical picture is very diverse and in 10% of cases the signs called carcinoid syndrome develop. Not infrequently it produces also peptide hormones. In the present paper the most modern diagnostic methods, possibilities of surgical and pharmacological treatment of this extremely interesting neoplasm are discussed.

Carcinoid Tumor↗