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Biomedical subjects

J M Dubernard

Publications and source records attributed to J M Dubernard.

At least 253 records · Page 14Linked to original sources
PubMed1979

[Study of a new case of male pseudohermaphroditism due to 17-ketosteroid reductase deficiency (author's transl)].

We studied a 17 year old patient with primary amenorrhea, hirsutixm, clitoral enlargment, poor breast development and 46, XY karyotype. The results shown in table clearly indicate a 17-ketosteroid reductase deficiency. In the view of previously described patients we can conclude that: 1) intensity of virilisation depends on both plasma testosterone and androstenedione levels; 2) importance of gynecomastia depends on plasma E2 but not E1 levels; 3) FSH levels are not correlated with circulating androgens or estrogens but presumably depends on importance of seminiferous tubules' lesions.

17-Hydroxysteroid Dehydrogenases↗
PubMed1978

[A new method of pancreatic transplantation. II. Double renal and pancreatic transplantation in a diabetic with renal failure (author's transl)].

A 41-year-old man who had suffered from insulin-dependent diabetes since the age of twenty and who had severe degenerative complications with chronic renal failure, underwent pancreatic transplantation. The graft was prepared by intraduct injection of neoprene in order to suppress the exocrine function of the gland. It was situated in the iliac fossa and has ensured the complete correction of diabetes for more than 10 months. This favourable situation made it possible to carry out a renal transplant which could not have been envisaged previously in this patient with very unstable and progressive diabetes who was dialysed under very difficult conditions.

Adult↗
PubMed1978

[A new method of pancreatic transplantation. 1 - Effects on the dog pancreas of the intraduct injection of neoprene (author's transl)].

Injection into the pancreatic ducts of a synthetic liquid gum (neoprene), which polymerises when it comes into contact with the fluid secreted by the gland, would appear to be a simple and effective means of suppressing exocrine secretion of the pancreas in the dog. Endocrine secretion was remained in the short and mid-term. The therapeutic implications of this new technique in the preparation of pancreatic transplants are discussed.

Amylases↗
PubMed1978

A new method of preparation of segmental pancreatic grafts for transplantation: trials in dogs and in man.

A new method of eliminating the exocrine function of the pancreas by obstruction of pancreatic duct with neoprene was investigated in dogs and applied to three cases of human segmental pancreatic transplantation. Neoprene is a liquid synthetic rubber which flocculates with changes in pH. In animals, progressive fibrosis of the pancreatic tissue occurs after injection of neoprene in the main pancreatic duct, leaving islets well vascularized and functioning for prolonged periods. Using this technique, three severely diabetic patients received a cadaver segmental pancreatic allograft. Blood sugar returned to normal levels within the first hours or days after operation. All three grafts continue to function 1.5, 2, and 8 months, respectively, following transplantation. If these results are confirmed by further clinical experience, this method may be of considerable assistance in the treatment of severe diabetes by pancreatic transplantation.

Adult↗