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Biomedical subjects

J M Dubernard

Publications and source records attributed to J M Dubernard.

At least 271 records · Page 15Linked to original sources
PubMed1978

Thoracic duct drainage and antilymphocyte globulin for renal transplantation in man.

Thoracic duct drainage resulting in a lymphocyte depletion of more than 20 x 10(9) cells was performed during the three months prior to transplantation in 37 patients. Results obtained in this group of patients were compared to those in transplant recipients similarly treated, over the same period, but not subjected to thoracic duct drainage. Both groups received comparable doses of antilymphocyte globulins, azathioprine and corticosteroids. No clear-cut difference in transplantation outcome was found when recipients of kidneys from related living donors (whether HLA identical or HLA haploidentical) were considered. By contrast, an improved transplant survival and a decreased incidence of rejection crises were observed in recipients of kidneys from cadaver donors when a thoracic duct drainage was performed prior to transplantation. The immunosuppressive effect of thoracic duct drainage, probably enhanced by antilymphocyte globulin treatment, is therefore a valuable adjunct to more conventional methods of pretreating human cadaveric transplant recipients.

Antilymphocyte Serum↗
PubMed1977

Suppression of the exocrine function as an aid to of segmental pancreatic transplantation in dogs.

The injection of neoprene into the pancreatic ducts appeared to be a simple and effective means of suppression of the pancreatic exocrine function in dogs. It was investigated in experiments performed in three groups of dogs the pancreas of which were injected with 1 to 6 ml of neoprene. In group I (injection alone), all animals showed pancreatic exocrine insufficiency, none was diabetic. In group II, the dogs received a substitutive treatment and a special diet, they survived in a good general condition up to the time of sacrifice. There was extensive pancreatic fibrosis with disseminated Langerhans islets. In group III, a cephalic pancreatectomy was performed after the injection of neoprene into the pancreatic ducts, 8 animals were alive and well after 3 to 15 months, and showed a normal level of blood sugar, insulin, glucagon and amylase without glycosuria.

Amylases↗