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Biomedical subjects

J Martin

Publications and source records attributed to J Martin.

At least 1,063 records · Page 59Linked to original sources
PubMed1978

[Osteo-articular lesions of the foot in diabetic patients. A systematic review of 1,501 radiological reports (author's transl)].

Osteo-articular changes observed in diabetic patients include diabetic osteo-arthropathy, infective osteo-arthritis, and osteo-arthrosis. A systematic review of 1,501 case-sheets demonstrated one or more bone lesions in 55% of the diabetic patients studied. There was a striking absence of the most typical lesions of the foot, probably party due to the fact that there has been an improvement in the treatment of diabetes. Osteolytic and reconstructive lesions were more common in women.

Aged↗
PubMed1977

[VP 16-213 in combination with endoxan, methotrexate and oncovin as polychemotherapy for bronchogenic carcinoma].

Thirty patients with bronchogenic carcinoma underwent an 8 week course of induction therapy consisting of cyclophosphamide, methotrexate, vincristine, and VP 16-213 (NSC 141 540). Those who achieved objective remission or tumor stabilization were then placed on an intermittent treatment schedule with the same drugs. Of the 30 patients, 17 had an objective response, 5 were unchanged and 8 progressed. Responses were more frequent in anaplastic carcinoma (13/19) than epidermoid or adenocarcinoma (4/11). The toxicity mainly consisted of leukopenia, thrombopenia, alopecia, nausea and vomiting. The implications of these findings in the planning of further chemotherapeutic programs are discussed.

Adenocarcinoma↗
PubMed1977

A new display technique for computer-processed digital scans.

This article presents a new approach for presenting scintigraphic images. The technique combines the conventional plotting the contour lines and the highlighting, by means of hatching, of the concavities (or convexities) of the 'surface' representative of radioactive distribution. The search for the surface features is achieved generally by the method of normal curvatures. An example with a phantom demonstrates the utility of this representation method.

Computers↗
PubMed1977

Improvement of cis-dichlorodiammineplatinum (NSC 119875): therapeutic index in an animal model.

Cis-Dichlorodiammineplatinum (CPDD) NSC 119875 was given at toxic doses (3 mg/kg) to three groups of dogs. The renal toxicity was avoided with massive prehydration and with mannitol induced diuresis. The bone marrow toxicity was unaltered by either manipulation. The data presented indicate that a better therapeutic index has been achieved by osmotic diuresis with mannitol. Blood levels and urine levels measurements show that the pharmacokinetics of the drug are unaltered, the urinary concentration of drug being low in the first few hours, but with similar urinary drug recovery in all three groups.

Animals↗
PubMed1977

Pentose utilizing variants of Novikoff hepatoma cells: modification of growth and morphological properties.

A series of variant lines that utilize multiple pentoses for growth in place of glucose have been isolated from an 8-azaguanine resistant line of Novikoff hepatoma cells (N1S167). These variants utilize for growth ribose, xylose, arabinose, and/or deoxyribose. The variants growing on pentose containing medium (a) exhibit a density dependent cessation of growth, (b) have a morphology change to a more flattened cell type, (c) become binucleated in the presence of cyto chalasin B, and (d) show an altered sensitivity to trypsin treatment.

Arabinose↗