Availability of the true Schiff's bases of lysine. Chemical evaluation of the Schiff's base between lysine and lactose in milk.
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Biomedical subjects
Publications and source records attributed to J Mauron.
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Results of a balance study of nitrogen, fat, electrolytes and trace-elements (Fe, Cu, Zn, Mn) with 3 1/i to 9 years old malnourished children in the Kwilu region (Zaïre) are given. The main components of the diets were fish, lactose free milk, caseinate, partial hydrolasate of albumin, fermented corn and soya (Soy-Ogi), medium-chain triglycerides, rice and the local foods manioc, peanuts and caterpillars. The lactose free milk and the Soy-Ogi were well tolerated since we found only a small quantity of non absorbed sugar in the faeces. Our results show that in children who have secondary intestinal malabsorption the use of a partial hydrolysate of lactalbumin and the medium-chain triglycerides is recommended and the substitution of the manioc by rice also. Caseinate gave satisfactory results in adult-malnutrition. We found a good retention of nitrogen, fat and phosphorus. For the latter an addition was necessary. The potassium balance was also positive, a content of 5 meq/kg body weight in the food gave a sufficient retention time. The sodium chloride content of the diet must be moderate because of the oedemas (2 meq/kg body weight). The determination of the vitamin content in the diet and their urinary excretion gave some indication of the balance of these nutrients. Children who had intestinal troubles showed only a slight positive or negative balance of calcium, magnesium, zinc, copper and manganese, since we found a high faecel excretion for these elements. These rather unsatisfactory results emphasis the necessity of first curing any intestinal aliments.
The question whether there is a real need for more protein is first critically reviewed and the two main ways of making more protein available are then exposed. They comprise the more efficient use of the protein already available and the synthesis of new protein. The possibilities offered by the oilseeds are then briefly expounded and the difficulties encountered in their practical application are evaluated. The texture meat-like products based on extruded soya and the more sophisticated spun fibers are mentioned. Protein synthesis using yeast, bacteria and algae as microorganisms is then described. The single-cell protein (SCP) products obtaine on different substrates (paraffins, alcohols or inorganic substrates) are evaluated as regards their general composition, amino acid content and nutritive value. The problems of wholesomeness and tolerance are briefly touched upon and the development of three generations of SCP products is envisaged, each having a higher degree of purity and being more suited as a food. Finally the prospects of SCP as human food are discussed.
This experiment compared the effects of (u) "early undernutrition" by rearing in large litters and (ii) an early handlin g stress, on avoidance learning in Swiss white mice. The two treatments, the first leading to permanent physical stunting and the second not, had similar and additive detrimental effects on avoidance performance. Treatment with the minor tranquillizer Chlordiazepoxide improved performance in all groups but had a proportionately greater effect on previously undernourished, handled mice. Thus the poor avoidance performace of mice reared in large litters appears to be largely independent of the growth stunting effect and more closely related to an elevated stress response produced by stress in early life.
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