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Biomedical subjects

J Nĕmec

Publications and source records attributed to J Nĕmec.

At least 73 records · Page 4Linked to original sources
PubMed1985

Estrogen receptors in human goitrous and neoplastic thyroid.

An attempt was made to quantify the number of specific estrogen binding sites in specimens of human goitrous or neoplastic thyroid tissue obtained by surgery. Using synthetic estrogen [3H]moxestrol as a radioligand, the concentrations of estrogen receptors found were very low (average 0.57 +/- 0.47 fmol mg-1 of protein) approaching the detection limit. Accordingly, no significant sex dependent differences in estrogen receptors could be revealed.

Estradiol Congeners↗
PubMed1985

Different patterns of blood sugar and serum insulin levels after different glucose preparations.

In a group of 20 in-patients oral glucose tolerance test was performed repeatedly using 100 g of glucose in weak tea and the same amount of glucose in form of commercial flavoured preparation Glukosa Test. Blood sugar (BS) and immunoreactive insulin (IRI) were estimated in venous blood at intervals 0, 30, 60, 90, 120 and 180 mins, respectively. During the test the values of BS alter Glukosa Test were lower at 120 and 180 mins interval than after the pure glucose. The values of IRI after Glukosa Test were higher from 60 to 120 mins interval. Insulinogenic index was therefore significantly higher at 30, 60 and 90 mins interval and in summarized value for the entire test. Our findings of different effects of the same amount of glucose administered in various forms on pattern of blood sugar and insulin cannot been explained from our material. The possibility of different activation of some regulatory mechanism--e.g. so called enteroinsular axis--should be considered.

Antigens↗
PubMed1984

The rational use of 201Tl scintigraphy in the evaluation of differentiated thyroid cancer.

Fifteen patients with differentiated thyroid cancer were examined following 131I thyroid ablation, of these seven were examined after radio-iodine therapy to disseminated neck cancer. They had no further radio-iodine uptake and were evaluated using a 201Tl scan. In thirteen patients there was a good correlation between the results and the clinical diagnosis, showing no uptake in seven subjects with negative clinical findings, and positive delineation of tumour tissue in the neck region in six patients. The remaining two patients with lymph node metastases after previous radio-iodine irradiation showed marked clinical regression of the metastases with absent uptake of both 131I and 201Tl, probably due to radiation-induced changes. The comparison of thallium scans with plasma thyroglobulin levels showed certain differences (high plasma thyroglobulin without any proof of remaining thyroid tissue in one patient and normal/low plasma thyroglobulin in the presence of a tumour in two patients) but both measurements could give additional information. It is believed that while in the differential diagnosis of a thyroid nodule no important information could be expected of scanning (compared with the high value of aspiration biopsy), the evaluation of patients without 131I uptake by 201Tl scans could provide important information for further therapy.

Adenocarcinoma↗
PubMed1983

Serum thyroglobulin determinations in patients with differentiated thyroid carcinoma.

Serum thyroglobulin levels were measured in 636 patients with differentiated thyroid carcinoma, in whom altogether 1240 determinations were performed in different phases of disease and treatment. A modified sensitive radioimmunoassay was employed using an own high-specific thyroglobulin antibody. The results showed that both the majority of patients with functioning metastases accumulating radioiodine and with non-functioning metastases which could not be detected by scanning had higher serum TG levels, compared with a group of healthy subjects. However, "normal" TG values in patients with metastases, especially non-functioning, were found too. Thus, these findings decrease the diagnostic value of the TG determination. The highest TG values were found in patients with distant metastases of differentiated thyroid carcinoma (in lungs and bones); on the other hand, the proportion of patients with lymph-node(s) metastases and "normal" TG levels was relatively high. We suggest that the serum TG determination cannot generally replace scanning with 131I and cannot serve as the only test, while being a helpful indicator in the long-term follow-up of differentiated thyroid cancer patients.

False Negative Reactions↗