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Biomedical subjects

J Novák

Publications and source records attributed to J Novák.

At least 145 records · Page 8Linked to original sources
PubMed1984

The pyrophosphate heart scintigram in children with progressive muscular dystrophy.

A pyrophosphate heart scintigram was obtained in 16 boys with progressive muscular dystrophy Duchenne. All of them showed pathological ECG findings and high plasma levels of CK, AST, ALT and LD. In 4 patients the scintigram was distinctly positive and in further 3 it reached borderline values. The remaining 9 boys had normal scintigraphic findings. Those with a positive heart scintigram had very high plasma levels of the enzymes under study which was suggestive of current progression of the disease. There was, however, no relation between heart scintigraphy and the affliction of the skeletal muscles expressed by means of an index.

Adolescent↗
PubMed1984

Scintigraphic detection of experimental myocardial infarction with 99mTc-2,3-dimercaptosuccinic acid.

Acute myocardial infarctions were produced by ligature of the left frontal descending coronary artery in 9 dogs. The possibility of scintigraphic imaging with 99mTc-DMSA 4 hrs after intravenous administration was studied. The infarctions were 4, 24 and 48 hrs old. The in vivo scan was positive in only one dog with a 4-hr old infarction. The in vivo scans were confirmed by the analysis of the radioactivity in tissue samples. The accumulation of the radiopharmaceutical increased slightly in 48-hr old lesions; however, this increase was not sufficient for a positive scintigraphic finding. Thus, we do not recommend 99mTc-DMSA for clinical use in acute lesions.

Animals↗
PubMed1984

Experiences with evaluation of immunosuppressive activity of alpha-globulin fraction of human blood plasma.

Presented are experiences with the determination of immunosuppressive activity of alpha globulin fraction of human blood plasma, crude (Cohn fraction IV), partially purified and so-called low-molecular isolates of these substances. For testing the following techniques were used: the lymphocytotoxic and lymphoagglutination test, rosette-inhibition tests with human lymphocytes and splenocytes of mice immunized with sheep erythrocytes, lymphocyte blastic transformation inhibition test using PHA stimulated cells as well as in the mixed culture, inhibition of haemolytic plaque formation tests, determination of GVH reactivity using regional tests in the popliteal nodes, determination of HVG reactivity by skin graft survival test, determination of the effect on formation of precipitins against soluble antigens. The best results were obtained with the determination of survival times for skin grafts and the regional test in the popliteal nodes Fairly reproducible results were obtained in experiments on influencing the humoral antibody response and inhibition of formation of precipitating antibodies. Of in vitro methods tests of inhibition of lymphocyte blastic transformation both after PHA stimulation and in the mixed culture are applicable. Fully unsuitable proved the rosette, lymphocytotoxic and lymphoagglutination tests. In vitro modification of haemolytic plaque formation tests. In vitro modification of haemolytic plaque formation test is unfit for testing the crude fractions or partially purified drugs, its in vivo modification seems more feasible provided a large panel of animals is examined.

Alpha-Globulins↗
PubMed1984

[The information system of thermic injuries in Hungary].

The Hungarian information system for burns is reviewed and some results are referred to. Factor analysis and regression analysis of data obtained from nearly 7000 burned patients underline the fact, that, in addition to the deep burn and the patient's age, accompanying diseases and localisation of the burn will have a significant influence on the prognosis, too.

Adolescent↗