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Biomedical subjects

J Nowicka

Publications and source records attributed to J Nowicka.

At least 55 records · Page 3Linked to original sources
PubMed1978

[Activity of acid phosphatase in saliva of industrial workers exposed to fluorine compounds].

Assuming that fluorine is a strong inhibitor of phosphatases, the activity of acid phosphatase in the saliva of 42 phosphorus fertilizers plant workers was studied. The workers were chronically exposed to fluorine compounds. Saliva had been collected for studies before the workers entered the productive plant and after the 1st and 2nd working hour. Enzyme activity was determined by Bessey and Lowry's method and was related to both the volume of the saliva and total protein level. The studies revealed a significant decrease in the activity of acid phosphatase after the 1st and 2nd working hour in those working in the division with a higher exposure to fluorine compounds. The results of these studies were confirmed by in vitro studies carried out additionally. Taking into account biological activity of acid phosphatase it seems that the observed phenomenon of inhibiting enzymatic activity may be connected with the frequency of parodontopathy in the studied group of workers. The results of these studies may be used for working out a biological test of workers' exposure.

Acid Phosphatase↗
PubMed1978

Group systems of serum proteins and erythrocyte enzymes in malignant lymphoma.

Four group systems of serum proteins (Hp, Gc, Gm, Km) and five group systems of erythrocyte enzymes (AP, PGM1, GPT, AK, EsD) were determined in 63 patients with malignant lymphoma. Statistical analysis of the distribution of the above mentioned systems in patients and Polish population samples did not reveal any significant differences, which points to the lack of any correlation between the disease and the group systems under examination.

Acid Phosphatase↗
PubMed1977

Disseminated intravascular coagulation (DIC) during superacute haemolysis in a patient with ovarian dermatoid cyst treated with rifampicin.

A 53-year-old female patient with ovarian dermatoid cyst and lung tuberculosis had been treated with rifampicin. During repeated rifampicin treatment she developed an acute haemolytic syndrome with haemorrhagic diathesis. Laboratory findings showed that it was caused by disseminated intravascular coagulation. Death ensued despite intensive administration of heparin and Trasylol. It is assumed that the repeated rifampicin application had provoked massive haemolysis by an allergic mechanism leading to thrombofibrinolytic haemorrhagic diathesis.

Antithrombins↗
PubMed1977

[A case of Osler-Rendu disease with simultaneous thrombopenia and a factor VIII inhibitor].

Long-term determinations of haemostasis factors in a case of Osler's telangiectasia revealed the temporarily simultaneous existance of periods of thrombocytopenia, a decrease of prothrombine and a reduction of the fibrinogen and plasminogen level. These findings considered as signs of consumption coagulopathy coincided with an increased bleeding tendency of the patient. The correlation existing between the clinical symptoms and the observed disorders of coagulation may possibly be explained by the appearance of an intravascular coagulation during the late period of the haemorrhagic diathesis, which could be proved by the simultaneous increase of fibrinogen degradation products. Moreover, the patient's plasma was capable of strongly inhibiting factor VIII of a normal plasma. The possible influence of plasmatic disorders of coagulation which are caused by secondary reasons on the clinical picture of a haemorrhagic diathesis primarily based on vascular conditions is discussed.

Endocarditis, Bacterial↗