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J O Croxatto

Publications and source records attributed to J O Croxatto.

At least 19 recordsLinked to original sources
PubMed1999

Pleomorphic adenocarcinomas of the ciliary epithelium. Immunohistochemical and ultrastructural features of 12 cases.

OBJECTIVE: To examine the immunohistochemical and ultrastructural features of the rare pleomorphic adenocarcinomas of the ciliary epithelium (CE). DESIGN: Retrospective case series. PARTICIPANTS: The study materials included 12 cases of adenocarcinoma of the ciliary epithelium: 9 cases of CE hyperplasia and 3 cases of CE adenomas. INTERVENTION: Histologic sections were stained with hematoxylin-eosin, alcian blue, periodic acid-Schiff, and occasionally with Masson trichrome. Additionally, the following immunohistochemical markers were used: Kermix (ae1/ae3 + ck1), cytokeratin 7 (CK7), cytokeratin 20 (CK20), epithelial membrane antigen, CAM 5.2, S-100 protein, neuron-specific enolase, glial fibrillary acid protein, smooth muscle actin, and vimentin. Five lesions were studied ultrastructurally. Clinical data were available in all cases, and follow-up was obtained in 9 of the 12 patients. RESULTS: Nine tumors occurred in phthisical eyes in adults. The tumor cells were arranged in tubular and solid patterns and surrounded by thick basement membrane (BM) material and fibrous stroma. Immunohistochemistry (IM) of adenocarcinomas showed positivity with kermix (8 of 12 lesions), CAM 5.2 (7 of 12), and CK7 (5 of 12). Ultrastructurally, the tumor cells were surrounded by a thick, homogeneous, and/or multilaminar BM and attached to each other by junctional complexes. CONCLUSIONS: Clinically, this intraocular neoplasm should be considered in adults with a longstanding blind eye with an epibulbar mass and/or proptosis of recent duration. Fatal cases only occurred in tumors with extraocular extension. Adenocarcinomas of CE should be differentiated from amelanotic melanoma and metastatic lesions by the presence of a thick BM material around the tumor cells and intraocular fibrosis. Immunohistochemistry is helpful in differentiating from melanomas but not helpful in cases of metastatic carcinomas.

Adenocarcinoma↗
PubMed1991

Sjogren's syndrome: a comparative study of impression cytology of the conjunctiva and buccal mucosa, and salivary gland biopsy.

The diagnosis of Sjogren's syndrome (SJ) as an underlying disease of keratoconjunctivitis sicca is important because of the many ocular and systemic complications. We compared the results of impression cytology of conjunctiva (ICC) and the results of labial salivary gland biopsy (LSB) with impression cytology of buccal mucosa (ICB) in 33 patients with SJ. LSB, ICC, and ICB were considered positive in all patients. Moderate to severe changes were graded in 85% of the biopsy specimens, 94% of the conjunctival specimens, and 76% of the buccal mucosa specimens. The rate of agreement between LSB and ICB was 97%. The use of ICB in the clinical ophthalmological examination may be helpful in patients with consistent history, and clinical and ocular findings, before the biopsy procedure.

Adolescent↗
PubMed1989

Benign fibrous tumor of the choroid.

A 32-year-old white woman presented with an amelanotic choroidal tumor in the left eye. Although a malignant melanoma could not be totally ruled out, some features suggested a benign tumor. The patient was followed up without treatment during a 2-year period. Neovascular glaucoma developed and the blind eye was enucleated. Histopathologic examination revealed a benign fibrous tumor of the choroid, presumably a fibrous histiocytoma.

Adult↗
PubMed1989

Genetic spontaneous late subluxation of the lens. A study of two families.

Patients with genetic spontaneous late subluxation of the lens may present signs and symptoms other than lens displacement due to secondary anatomic alteration of the anterior segment. Two families are described, one of them with affected individuals in five successive generations. The vast majority of the patients sought consultation because of progressive myopia or intermittent acute intraocular hypertensive crisis which obscured the basic condition. Upon recognition of the disease, the affected patients underwent an uneventful intracapsular extraction. Histopathologic examination of the removed lenses suggested a dysplastic development of lens zonules.

Adult↗
PubMed1989

Unsuspected mycobacterial endophthalmitis with increased aqueous lactate dehydrogenase levels in a child.

A 12-year-old boy had chronic uveitis resistant to medical therapy OS. Clinical examination and serologic tests did not show any infectious or systemic disease. Cytologic study from aqueous paracentesis revealed atypical cells. Ultrasonography disclosed diffuse posterior chorioretinal thickening. The diagnosis of diffuse retinoblastoma was considered, and an aqueous aspirate was assayed for lactate dehydrogenase. It contained six times the level present in a matching sample of serum. The blind eye was enucleated, and pathologic examination showed a necrotizing granulomatous endophthalmitis containing acid-fast bacilli.

Aqueous Humor↗
PubMed1988

Hydatid cysts of the orbit. A review of 35 cases.

The authors reviewed 35 cases of orbital hydatid cysts, which represented 5% of orbital surgical cases seen from 1944 to 1985. The average age was 16 years (range, 2-57 years). Slowly progressive unilateral exophthalmos, with or without pain, was the most frequent clinical manifestation. Computed tomography (CT) of the orbit demonstrated a well-circumscribed mass. Ultrasonography showed an anechoic cystic mass. The parasitic membrane and contents were surgically removed through an orbital approach. Hydatid cysts should be included in the differential diagnosis of unilateral exophthalmos in patients from countries where echinococcosis is endemic. Preoperative recognition is important for planning an appropriate surgical treatment in avoiding complications.

Adolescent↗
PubMed1988

Clinically atypical granular corneal dystrophy with pathologic features of lattice-like amyloid deposits. A study of these families.

Four patients from families in Pennsylvania, Massachusetts, and Argentina were diagnosed clinically as having granular dystrophy. Results of pathologic examination of the corneal buttons from each patient after penetrating keratoplasty confirmed granular deposits in the anterior third of the stroma. Amyloid was demonstrated within some of these granular deposits by Congo red staining with birefringence and dichroism and by electron microscopy. In addition to the morphologically granular deposits, numerous fusiform deposits identified as amyloid by histochemistry and electron microscopy and morphologically identical to those seen in lattice corneal dystrophy were detected deep to the granular deposits. It was further shown that the histochemical pattern of staining of the granular material by a series of lectins was similar to that present in corneas with lattice dystrophy. Although a relationship between these patients cannot be definitively proven, each family traces its origins to the Italian province of Avellino.

Adult↗
PubMed1988

Atypical corneal dystrophy with stromal amyloid deposits.

Corneal dystrophies are distinctive clinically and histopathologically; however, variations do occur. We present two cases of stromal amyloidosis from one family masquerading other corneal dystrophy. The two cases are from a six-generation family with an autosomal dominant corneal dystrophy resembling Reis-Bucklers' dystrophy. In these cases, neither the propositus nor other family members showed typical lattice lines. Light and electron microscopy of the obtained corneal buttons disclosed amyloid stromal deposits. The clinicopathologic correlation of these cases suggests that this family represents a variant of stromal amyloid dystrophies.

Adult↗
PubMed1987

Malignant melanoma of the conjunctiva. Report of a case.

Malignant melanomas of the conjunctiva are extremely rare in children. The authors report an 11-year-old boy who had a nodule at the limbus in a pigmented area since early childhood. The lesion was excised and the diagnosis of atypical compound nevus was made. Five months later, the patient returned with multiple nodules in the bulbar and palpebral conjunctiva. One of the lesions was excised, and the diagnosis was malignant melanoma. He was lost for follow-up for 6 months; then he presented a large pigmented, vascularized mass protruding through the palpebral aperture. Results of systemic workup for metastatic disease were negative, and an exenteration was performed. A few months later, cervical lymphadenopathy developed followed by extensive metastatic disease.

Child↗
PubMed1986

Inflamed eye in Marfan's syndrome with posteriorly luxated lens.

A 34-year-old man with Marfan's syndrome complained of redness and pain in the left eye. The right eye had been blind because of untractable retinal detachment. The left eye had had three surgical procedures for retinal detachment, and the lens had been luxated in the vitreous for more than 14 years. Ultrasonography demonstrated the spontaneously luxated lens as the possible cause of the inflammatory reaction. The diagnosis of lens-induced endophthalmitis was confirmed by histopathologic examination of the excised lens.

Adult↗
PubMed1986

Superficial involvement in lattice corneal dystrophy.

Twenty-one corneas with lattice dystrophy were studied histologically to evaluate the magnitude of superficial lesions. The compromise included epithelium disarray and atrophy, degenerative pannus, disruption and absence of Bowman's layers, amyloid deposits, and elastotic deposits. These changes were progressive according to patients' age at time of keratoplasty. Oxytalan fibers, an elastic component, were found in affected corneas. The relation of these fibers to elastotic deposition and abnormal fibrillogenesis in lattice corneal dystrophy is discussed.

Adolescent↗
PubMed1985

Bilateral and massive lipoidal infiltration of the cornea (secondary lipoidal degeneration).

A 41-year-old white man presented with bilateral white infiltration of the cornea from limbus to limbus. Extensive examination revealed no manifestations of disorders of lipid metabolism and the patient gave no history of previous ocular disease. VDRL and other serological tests were negative. The corneal button removed by penetrating keratoplasty from the right eye was studied by light microscopy, histochemistry and electron microscopy. The light microscopic appearance was consistent with lipoidal degeneration of the cornea associated with stromal vascularization and chronic keratitis, more likely a secondary lipoidal degeneration. Cholesterol clefts were seen in all levels of the stroma focally surrounded by a foreign body giant cell reaction. Lipid vacuoles were observed in extracellular and intracellular locations within histiocytes and fibroblasts in vascularized and inflammed areas. Lipid stains disclosed cholesterol crystals, neutral fats, and phospholipids.

Adult↗
PubMed1984

Cavitary melanocytoma of the ciliary body.

The clinical and pathologic findings of a patient with an unusual cavitary melanocytoma of the ciliary body are presented. Clinically and with ultrasonography the lesion appeared to have a cystic component. Differential diagnoses included a malignant melanoma or a cyst, and the lesion was excised by iridocyclectomy.

Ciliary Body↗
PubMed1983

Angle closure glaucoma as initial manifestation of melanocytoma of the optic disc.

A 44-year-old man had progressive visual loss and pain due to angle-closure glaucoma associated with a papillary pigmented lesion. The eye was enucleated because of intractable pain and the suspicion of a malignant tumor. Histologic and electron microscopic examination of the enucleated eye revealed a partially necrotic melanocytoma of the optic nerve. There was histologic evidence of vaso-occlusive disease within the optic nerve that resulted in ischemic necrosis of the tumor, hypoxic retinopathy and neovascular glaucoma. This report emphasizes that significant complications may occur in otherwise typical intraocular nevi.

Adult↗
PubMed1983

Retinoblastoma masquerading as ocular inflammation.

The clinical and pathologic findings of a 9-year-old girl with retinoblastoma masqueraded as atypical intraocular inflammation are presented. Histopathologic study revealed a diffuse infiltrating retinoblastoma with seeding of tumor cells into the vitreous cavity and anterior chamber. In tumors with this growth pattern, ultrasonography is of little value. Cytologic examination of aqueous and vitreous aspirates may be misinterpreted and should be evaluated carefully. Because of the seeding of tumor cells, lactate dehydrogenase assay is of diagnostic value prior to considering definitive therapy.

Child↗