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J O Croxatto

Publications and source records attributed to J O Croxatto.

28 records · Page 2Linked to original sources
PubMed1982

Atypical histopathologic features in sympathetic ophthalmia. A study of a hundred cases.

One hundred cases of clinically acceptable sympathetic ophthalmia (SO) were evaluated histologically to determine the incidence of atypical features and correlate them with the severity of choroidal inflammation. The inflammatory response in the choroid varied from a focal non-granulomatous to a diffuse non-necrotizing granulomatous process. The choriocapillaris was focally involved rather frequently (in 40% of the cases). This was associated with severe inflammation. Chorioretinal adhesions were noted in 7% of the cases. Retinal detachment was observed in 50% of the cases, and this was associated with severe uveal inflammation. Fifty percent of the cases showed retinal perivasculitis and 18% a mild inflammatory infiltrate of the retina. Involvement of the meninges (a finding present in 22% of the cases) and severe inflammation in the scleral canals were both related to the severity of choroidal inflammation. Lens-induced endophthalmitis was observed in 14 cases and was not associated with the severity of the choroidal inflammation. Our observations indicate that the changes interpreted as atypical in SO are usually associated with severe choroidal inflammation, suggesting that these features may be the response to high doses of antigenic agent. The classical histopathologic description of SO may represent only one manifestation of the pathologic response of this disease.

Adolescent↗
PubMed1982

Hemangiopericytoma of the orbit: a clinicopathologic study of 30 cases.

The clinical and pathologic features of 30 orbital hemangiopericytomas were reviewed. An effort was made to determine the clincopathologic characteristics that may correlate with the biologic behavior. Histopathologic criteria evaluated included degree of cellularity, nuclear atypia, mitotic activity, tumor size, and the presence of hemorrhage and necrosis. Histopathologically, 16 tumors were classified as benign, five as borderline, and nine as malignant. Follow-up information was obtained in 27 cases (mean duration of follow-up period was five and one-half years). Eight tumors recurred (30 per cent). Five patients died, four with widespread metastases (15 per cent) and one of unrelated causes. Tumors that recurred or metastasized were distributed among all three histologic groups. The interval between the onset of symptoms and metastasis for three of the four lethal tumors was 31 years, 28 years, and 8 1/2 years; in the fourth case it was unknown. For the entire series, the five-year actuarial survival rate was 89 per cent. Although the number of cases is too small to serve as a basis for firm conclusions, the lack of unequivocal correlation between the histologic features and clinical behavior is consistent with the unpredictable behavior of this neoplasm, as concluded by other investigators. Because of the apparent circumscription of most of these tumors, complete surgical excision rather than exenteration is recommended. Metastasis usually develops late in the clinical course of the disease, indicating that long-term follow-up studies are required before a cure can be assumed.

Adolescent↗
PubMed1982

Juvenile xanthogranuloma of the optic nerve, disc, retina, and choroid.

A 20-month-old infant found to have a blind eye with neovascular glaucoma was thought to have a neoplasm of the optic nerve for which enucleation was performed with resection of a long segment of optic nerve. Microscopic examination revealed the enlarged optic nerve and optic papilla to be infiltrated densely by histiocytic cells, including Touton giant cells, all containing large amounts of neutral fat. The histologic picture was indistinguishable from that of juvenile xanthogranuloma. Occlusion of the central retinal vessels had led to hemorrhagic infarction of the retina and neovascular glaucoma. Thorough clinical and laboratory investigations repeated over a period of more than 2 1/2 years failed to disclose any evidence of a systemic disease, and the child has remained in good health. This is believed to be a unique case of juvenile xanthogranuloma of the optic nerve and disc.

Child, Preschool↗
PubMed1982

Unusual ciliary body tumor. Mesectodermal leiomyoma.

A 23-year-old white woman presented with a pigmented ciliary body mass in the left eye. The tumor appeared to transilluminate when observed with indirect illumination. Clinically the tumor was considered to represent either a malignant melanoma or a cyst and was excised by iridocyclectomy. Electron microscopic examination established the smooth muscle nature of the tumor. The literature on this unusual tumor is reviewed. Furthermore, this report serves to emphasize the value of iridocyclectomy in the diagnosis and treatment of ciliary body tumors.

Adult↗
PubMed1981

Sympathetic ophthalmia after pars plana vitrectomy-lensectomy for endogenous bacterial endophthalmitis.

A 71-year-old woman developed an endogenous bacterial endophthalmitis in her right eye. Because of the rapid progression she was treated by para plana vitrectomy-lensectomy and with antibiotics and corticosteroids. The patient improved after the antibiotic therapy. One month later she had a recurrence of the inflammatory signs in the same eye. Examination disclosed lens remnants in the vitreous. Because of the possibility of phacoallergic uveitis, she underwent a second vitrectomy. The corticosteroid dosage was increased. She did well until three months later when, while still taking corticosteroids, she noted loss of visual acuity in the left eye, accompanied by bilateral inflammatory signs. Sympathetic ophthalmia was suspected and the blind right eye was enucleated. The choroid was grossly unremarkable; the routine sections disclosed many inconspicuous foci of mononuclear infiltration. Tangential sections of flat-embedded choroid, however, showed ill-defined nests of epithelioid cells containing phagocytosed melanin, supporting the diagnosis of sympathetic ophthalmia. To our knowledge, this is the first published report of this complication after pars plana vitrectomy-lensectomy in the absence of nonsurgical trauma or other surgical procedures.

Aged↗
PubMed1980

Intracellular inclusions in meningothelial meningioma. A histochemical and ultrastructural study.

This is a study on the histochemical and electron microscope findings of the intracellular inclusions in a case of meningothelial meningioma of the frontoethmoidal region with orbital involvement. The inclusions are PAS-positive, diastase resistant, and stain strongly positive with the modified Morel-Sisley reaction for protein-bound tyrosine and weakly with dihydroxy-dinaphthyl-disulfide (DDD) for the demonstration of sulfhydryl (SH) and disulfide (S-S) groups of proteins. These staining reactions suggest the inclusions are composed of conjugated proteins (glycoproteins). Ultrastructurally, the inclusions are located within intracellular spaces lined by microvilli and are composed of granular material, usually forming a dense core that is intermixed with small vacuoles. Numerous desmosomes and whorls of tonofibrils are concentrated around them. Our findings support the view that the intracellular inclusions, which are rarely found in meningiomas, represent an active secretory product of the meningothelial cells rather than a degenerative or phagocytic process.

Female↗
PubMedDate not supplied

[Floppy eyelid syndrome. 5 cases].

First described in 1981, the floppy eyelid syndrome is characterized by loose upper lids that evert spontaneously and chronic papillary conjunctivitis. We present five patients with this syndrome and illustrate the distinctive clinical findings.

Adult↗