Biomedical subjects

J O Marquez

Publications and source records attributed to J O Marquez.

8 recordsLinked to original sources

PubMed2000

Interleukin-5 and interleukin-10 are major cytokines in cerebrospinal fluid from patients with active neurocysticercosis.

Neurocysticercosis (NCC) is a common neurological disorder especially in developing countries, caused by infection of the brain with encysted larvae of the tapeworm Taenia solium. Seizures are a common finding associated with this disease. The objective of the present study was to evaluate the correlation between the levels of various cytokines present in the cerebrospinal fluid (CSF) of patients with NCC and the severity of the disease. The levels of the cytokines IL-1ss, TNF-alpha, IL-5, IL-10 and IFN-gamma were determined in the CSF of 22 patients with active NCC, 13 patients with inactive NCC and 15 control subjects. CSF from patients with active NCC presented significantly higher IL-5 levels compared to control subjects. IL-5 and IL-10 levels in CSF from NCC patients with inflammatory CSF were significantly higher than those detected in non-inflammatory CSF. These results show a predominant Th2 lymphocyte activation in human NCC and also indicate the possible use of cytokines in the CSF as a marker for the differential diagnosis between inactive disease and the active form of NCC.

Animals↗

PubMed1998

Chagasic meningoencephalitis in the immunodeficient.

Based on their own experience and on the literature, the authors compare the brain pathology due to HIV+ associated Trypanosoma cruzi reactivated infection to that described for the natural history of the Chagas' disease (CD). The peculiar focal necrotizing chagasic meningoencephalitis (MECNF) which appears only in immunedeficient chagasics, especially when the deficiency is due HIV is a safe criterion for reactivation of CD. MECNF morphologic findings are unlike to those found either for some cases of acute phase CD or for chronic nervous form of CD.

AIDS-Related Opportunistic Infections↗

PubMed1998

Terson's syndrome. Report of a case with favorable outcome.

Terson's syndrome is characterized by the presence of a subarachnoid hemorrhage accompanied by retinal and vitreous hemorrhage leading to a not very favorable prognosis. We describe a case with a good outcome, probably because of a early diagnosis and medical intervention. We emphasize the routine optician's check up as very important in the evaluation of a prognosis in the cases of a suspect intracranial hemorrhage.

Adult↗

PubMed1987

Regional dipyrone nociceptor blockade: a pilot study.

Eighteen of nineteen patients reported relief from chronic pain (40 to 100%, analogue scale) lasting from a few hours to up to two months after single or repeated regional infusion of dipyrone into a limb. A tendency towards increased duration of pain relief was observed after repeated infusions. The present series of observations in man and experiments with rat paw hyperalgesia are consistent with the interpretation that dipyrone blocks a persistent hyperalgesic state which may result from a previous frequent nociceptive stimulation (memory?) rather than an ongoing inflammatory process.

Aminopyrine↗

PubMed1979

Antibodies against neurons in chronic Chagas' disease.

Severe qualitative and quantitative alterations of the autonomic system inervating the heart and other organs have been demonstrated in experimental and natural Chagas' disease. These facts led us to search for the presence of antibody to neurons in 230 chagasic sera by an indirect immunofluorescence technique. Our results indicated that 83% of the chagasic patients presented IgG antibodies and 7% IgM antibodies to neurons. All control sera were negative. The demonstrated antibody to neurons presented cross-reaction against neurons of the central and peripheral nervous system (sympathetic and parasympathetic) and also against neurons of different species.

Absorption↗

PubMed1978

[Amyotrophy due to parietal lobe lesions].

A bibliographical revision about Silverstein's amyotrophy, with a historical sight analizing the physiopathogeny and its clinical manifestations is reported. The authors discussed the possible cause of the few references in the literature about the matter and relate three cases; they leave a blank in one of them with amyotrophy in the other side and the same side of the lesion, that got better with surgical treatment. This was not found in the bibliographical revision that has been looked for.

Adult↗

PubMedDate not supplied

[Association of encephalic vascular accidents and Chagas disease].

The frequency of strokes was studied in chronic chagasic and years of age, non-chagasic patients, older than 15 coming to necropsy in Uberaba, from 1979 than 1988. The study consisted of paired sex and age matched controls. Two hundred and eight pairs were analysed. Either ischemic or hemorrhagic strokes were found in 41 (19.7%) of the chagasics and in 55 (26.4%) of the non-chagasic, a difference not significant at the level of 5%. Twelve (75%) of the former had infarcts and 4 (25%) had brain hemorrhage; five (31.3%) of the non-chagasics had ischemic strokes and 11 (68.7%) had hemorrhagic strokes. The differences were significant to the level of 5%. The results indicate a high frequency of ischemic strokes in human Chagas' disease and demonstrate a lesser frequency of hemorrhagic stroke in chagasics when compared with non-chagasics.

Adolescent↗

PubMedDate not supplied

[Toxoplasmic and chagasic meningoencephalitis in patients with human immunodeficiency virus infection: anatomopathologic and tomographic differential diagnosis].

Twenty-two HIV+ patients with encephalitis were studied. Of these, 7 had meningoencephalitis due to Toxoplasma gondii (MT) and 15 due to Trypanosoma cruzi (MC). Pathologic and computerized axial tomography (CAT) changes were compared. We found that focal necrotizing encephalitis due to Toxoplasma involved the cerebral cortex and the basal ganglia, whereas lesions due to Trypanosoma cruzi were centered in the white matter, sometimes extending into the cortex. Hemorrhages, myelin lesions and organisms were more pronounced in chagasic than in toxoplasmic encephalitis. These findings are consistent with the literature reviewed.

Acquired Immunodeficiency Syndrome↗