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PubMed · 3330464

Regional dipyrone nociceptor blockade: a pilot study.

J O Marquez·S H Ferreira
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Abstract

Eighteen of nineteen patients reported relief from chronic pain (40 to 100%, analogue scale) lasting from a few hours to up to two months after single or repeated regional infusion of dipyrone into a limb. A tendency towards increased duration of pain relief was observed after repeated infusions. The present series of observations in man and experiments with rat paw hyperalgesia are consistent with the interpretation that dipyrone blocks a persistent hyperalgesic state which may result from a previous frequent nociceptive stimulation (memory?) rather than an ongoing inflammatory process.

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AminopyrineAnalgesiaAnimalsChronic DiseaseClinical Trials as TopicDipyroneHumansInfusions, Intra-ArterialNociceptorsPilot ProjectsRatsClinical TrialJournal ArticleResearch Support, Non-U.S. Gov't

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J O Marquez, S H Ferreira. 1987. Regional dipyrone nociceptor blockade: a pilot study.. https://pubmed.ncbi.nlm.nih.gov/3330464/

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