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Biomedical subjects

J Olszewski

Publications and source records attributed to J Olszewski.

At least 55 records · Page 3Linked to original sources
PubMed1997

[Treatment results of acoustic trauma].

20 patients aged from 18 to 42 treated in the past few years because of acoustic trauma. Together the investigations concerned 24 years. Therapeutic schema comprised intravenous infusion--Sermion (Nicergoline--amp. a 4 mg) or Cavinton (Vinpocetine--amp. a 10 mg) 1 amp.--twice a day for 10 days. The treatment of 60% of the patients started in the first week after the trauma occurred, of 20% in the second week and the remaining 20% later on after 15 days when the trauma took place. The obtained results of treatment both of improvement of hearing (79.2%) and tinnitus (66.6%), support the necessity of treatment of acoustic trauma independently from the time that passed after trauma had occurred. Better results of audiometric improvement of hearing (54.2%) and tinnitus disappearance (50%) were obtained in the patients whose treatment started in the first week after trauma. The improvement of hearing and tinnitus disappearance was more observed in patients after treatment by using Sermion than Cavinton.

Adolescent↗
PubMed1997

[Clinical evaluation of Olbas oil effect on nasal mucosa in acute rhinitis patients during common cold].

The aim of the study was the clinical evaluation of the effect of Olbas oil on nasal mucosa in patients with acute rhinitis during common cold. 15 patients with 2-3 days history of acute rhinitis during common cold, both sexes, in the age between 23-47 were investigated. All the examinations were done before using, after the first inhalation, and after 7 days of Olbas oil administration. The investigation before using Olbas oil was comprised of: history data, general and otorhinolaryngological examination with particular evaluation of nasal mucosa, anterior rhinomanometry, saccharin translocation time, olfactometry, microbiological cultures, histamine nasal provocation test. At the end, after 7 days of Olbas oil inhalation 3 times a day for 4 minutes 4 drops of Olbas oil applied into a handkerchief, all the test were done again, as at the beginning. The study showed a good of the effect of Olbas oil on nasal mucosa in patients with acute rhinitis during common cold.

Acute Disease↗
PubMed1997

[Selected immunological studies of chronic purulent and hypertrophic otolaryngological diseases].

The aim of this work was the comparison of selected immunological parameters in patients with chronic purulent and hypertrophic otorhinolaryngological diseases who were to be operated on. The patients were divided into two groups: 1-31 patients aged 17-58 with chronic purulent otorhinolaryngological diseases. The following immunological parameters were carried out: rheumatoid factor (RF), immunoglobulins IgG, IgM, IgA, proteinogram including the level of albumin, globulin alpha1, alpha2, beta and gamma. In chronic purulent otorhinolaryngological diseases the characteristic features are the reduction of the level of globulin alpha1 (67.7%) and gamma (35.5%), while in hypertrophic cases globulin alpha1, and beta--91.7% each.

Abscess↗
PubMed1997

[The evaluation of granulocyte function before and after surgical treatment in patients with chronic inflammation of the middle ear and palatine tonsils].

The aim examinations was the evaluation of granulocytes (PMNL) pre- and postsurgical treatment in patients with chronic inflammation of middle ear and palatine tonsils. The examined 40 persons and divided into three groups: I--18 patients with chronic inflammation of middle ear, II--10 ones with chronic tonsillitis and III--12 healthy persons. There were evaluated: "in vivo" and "in vitro" migration, bactericidal index and absorption of S. aureus labeled 14C isotope (phagocytic index) in the own modification. Preoperative treatment in patients with chronic inflammation of middle ear and palatine tonsils in comparison to the healthy were noticed: characteristic increase of the migration area, the MIF liberation and the phagocytic index, decrease in the bactericidal index (but more in group II). After a year postsurgical treatment the function of granulocytes in patients of group II was more similar to the healthy than in group I.

Adolescent↗
PubMed1997

[Clinical studies of Olbas oil tolerance and its effect on nasal mucosa in healthy volunteers].

The aim of the study was the clinical examinations of the tolerance and effect of Olbas oil on nasal mucosa in healthy volunteers during permanent 4 weeks administration. 23 healthy volunteers both sexes in the age between 20-50 were investigated. This investigations consisted of: history data, general and otorhinolaryngological examination, with particular evaluation of nasal mucosa, anterior rhinomanometry, olfactometry, saccharin translocation time, microbiological cultures, histamine nasal provocation test. Besides, each patient has follow up self evaluating chart of symptoms and adverse effect from the eyes, nose, pharynx and others. All the examined persons showed a very good tolerance of Olbas oil after 28 days of inhalation.

Adult↗
PubMed1996

A matrix metalloproteinase-generated aggrecan neoepitope as a marker of skeletal maturation and aging in cartilage.

OBJECTIVE: To quantify the matrix metalloproteinase-induced neoepitope F(M/V)DIPEN (Phe-[Met/Val]-Asp-Ile-Pro-Glu-Asn341) in guinea pig and rabbit cartilage during aging. METHODS: Cartilage was taken from the stifle joint, nasal septum, and xiphoid process in guinea pigs and rabbits at selected ages. The cartilage was then extracted and evaluated for F(M/V)DIPEN levels by radioimmunoassay. RESULTS: In the 3 tissues studied, there were major increases in F(M/V)DIPEN levels during skeletal maturation and aging in both the guinea pig and rabbit cartilage. Except for spontaneous osteoarthritis that develops in guinea pigs with aging, increases in the neoepitope were not correlated with arthritis pathology. CONCLUSION: Increases in the level of F(M/V)DIPEN in cartilage occur as a result of skeletal maturation and aging. This physiologic accumulation of F(M/V)DIPEN in cartilage should be considered when using the neoepitope as a disease marker in arthritis.

Age Factors↗
PubMed1996

[Aeroacoustic and pneumotachometric studies in the evaluation of vicarious voice in laryngectomy patients].

The aim the study was showed some spirometric and aerodynamic parameters of the respiratory system and of vicarious voice at laryngectomized patients, which were performed in plethysmographic cabin and by using of pneumotachometer. Clinical material stated 20 laryngectomized men, aged 45-77 years, who were divided into two groups (by Pruszewicz): A-well or very well speaking and B-bad speaking. The obtained results showed that laryngectomized well or very well speaking made bigger work of the respiratory system during vicarious voice than bad speaking ones. The well and very well speaking patients used twice (in case of consonants) and three times (in case of vowels) the volume of oesophageal-throat's air greater than bad speaking patients. Aerodynamic examinations in plethysmographic cabin allows for monitoring of vicarious voice at laryngectomized after operation and qualification some of ones for voice prosthetization in the aim of voice amplification.

Aged↗
PubMed1996

[Management of breech delivery and its influence on the newborn].

Authors analyse the newborns general well-being after the breech delivery in the two-years periods in 1983-84 and 1993-94. During this period of time the routine delivery by the caesarean section in primiparas was introduced. The statistically significant improvement in the general state on newborns measured by the Apgar score was observed in primiparas. All other data were comparatively similar.

Apgar Score↗
PubMed1996

[Forceps delivery--obstetric indications and outcome].

Authors analysed 170 forceps delivery in comparison to the control group of normal vaginal delivery. We analysed mothers age, obstetrical history, gestational age and duration of labour as well as traumatization, loss of blood and hospitalisation time. Analysed concerned as well the newborns state in the Apgar score its delivery way and newborn injuries. The most frequent indication for the forceps delivery was the imminent foetal asphyxia. The second stage of delivery lasted significantly longer, the blood lost was greater and the hospitalisation prolonged. Newborns presented poorer after-delivery condition measured in the Apgar score.

Adult↗
PubMed1996

[Morphometric analysis of the human placenta in physiologic term pregnancy].

Thirty placentas (after physiological deliveries of full term pregnancies) were morphometrically examined. Computer aided analysis of microscopic picture was used in those examinations. Measurements of terminal villi and epithelial plates were underwent. The efficiency of measuring methods was confirmed in morphometric examinations. The area of metabolic transport in placental plates was estimated to 1,222 m2. The results of measurements may constitute the basis for further examinations on morphology placenta.

Cell Count↗
PubMed1995

Quantification of a matrix metalloproteinase-generated aggrecan G1 fragment using monospecific anti-peptide serum.

Several members of the matrix metalloproteinase family have been reported to cleave aggrecan in the interglobular domain between Asn-341 and Phe-342. An antiserum was prepared against a peptide conjugate corresponding to the C-terminal sequence of the matrix metalloproteinase-generated aggrecan G1 fragment (Phe335-Val-Asp-Ile-Pro-Glu-Asn341). A quantitative radioimmunoassay, with a limit of detection of about 80 pM, was developed using this antiserum. This antiserum requires the free carboxyl group of the C-terminal asparagine for optimal recognition. If the C-terminal asparagine is excised from the sequence, replaced with closely related amino acids, or extended across the matrix metalloproteinase cleavage site, there is a 40-10,000-fold loss in detection. Using peptides cleaved from the N-terminus, it was determined that the antiserum requires the entire Phe-Val-Asp-Ile-Pro-Glu-Asn sequence for optimal recognition. The radioimmunoassay detects matrix metalloproteinase-generated G1 fragments with similar sensitivity to the Phe-Val-Asp-Ile-Pro-Glu-Asn peptide, but it does not recognize intact aggrecan. Immunoreactive aggrecan G1 fragments of molecular mass 50 kDa are generated by the matrix metalloproteinases stromelysin and gelatinase A. In contrast, under identical conditions, the closely related metalloproteinases, gelatinase B and collagenase, as well as cathepsin G, cathepsin B and human leucocyte elastase, did not generate a G1 fragment recognized by the antiserum. The anti-Phe-Val-Asp-Ile-Pro-Glu-Asn serum detects stromelysin-generated aggrecan G1 fragments from mouse, guinea pig, rabbit and human, indicating that the detection is not species-specific. This antiserum and radio-immunoassay should be useful for quantifying and characterizing matrix metalloproteinase-generated aggrecan G1 fragments in articular cartilage and synovial fluids from humans and various animal models of articular-cartilage destruction.

Aggrecans↗
PubMed1995

In vivo effects of stromelysin on the composition and physical properties of rabbit articular cartilage in the presence and absence of a synthetic inhibitor.

OBJECTIVE: To characterize the effects of intraarticular injection of recombinant human stromelysin (SLN) on the matrix composition and physical properties of cartilage from lapine stifle joints and the modulation of these effects by the systemic administration of an N-carboxyalkyl synthetic matrix metalloproteinase inhibitor, L-696,418. METHODS: Female 6-8-week-old New Zealand white rabbits received an intraarticular injection of 100 micrograms activated SLN in 1 stifle joint and buffer in the contralateral control knee; these animals were killed after 1 hour. A separate group of animals received an intravenous injection of either 30 mg/kg L-696,418 or buffer prior to intraarticular injection of SLN. Joints were dissected and analyzed for proteoglycan (PG) loss into joint fluid, tissue biochemical composition, and histology by toluidine blue or anti-VDIPEN antibody staining, or were frozen for physical property analysis. Disks of femoropatellar groove cartilage were harvested from the stifle joint and tested in uniaxially confined compression for determination of electromechanical and mechanical properties. RESULTS: Lapine stifle joints that received injection of SLN without systemic administration of L-696,418 showed a 13-fold increase in loss of PG into synovial fluid. Cartilage from these joints showed significant decreases in streaming potential at 1 Hz and electrokinetic coupling coefficient, but no change in equilibrium modulus, dynamic stiffness, or hydraulic permeability. Systemic treatment with L-696,418 resulted in a significant decrease in loss of PG into joint fluid and elimination of changes in cartilage high-frequency streaming potential and coupling coefficient in joints that were injected with SLN. CONCLUSION: The 1-hour exposure to SLN in vivo resulted in loss of PG and exposure of the VDIPEN epitope of the aggrecan core protein in the superficial region of the tissue near the articular surface. This highly localized degradation resulted in electromechanical behavior changes, but little or no change occurred in mechanical properties. Systemic administration of L-696,418 significantly decreased loss of PG from cartilage and prevented the highly localized tissue degradation and the resultant changes in electromechanical behavior caused by intraarticular SLN injection.

Animals↗
PubMed1995

[Changes in levels of human placenta lactogen (hPL), progesterone, and estriol in blood serum and estrogens in urine during gestational diabetes mellitus].

The aim of the study was estimation of endocrinological function of placenta in pregnancy complicated by GDM. The study were performed on a group 13 women with GDM and 14 women in normal pregnancy. All women with GDM were treat by diet and intensive insulinotherapy with self monitoring levels of glucose. In women with GDM level of fructosamine and HbAlc were significant higher but in normal range. In 28, 36, 37, 38, 39 week of pregnancy were determined levels of hPL, oestriol and progesterone in serum and daily excretion of oestrogens in urine. From 36 week of pregnancy levels of hPL, oestriol and progesterone were significant lower in women with GDM. In 39 week of pregnancy level of hPL was 9.34 micrograms/ml vs. 12.71 micrograms/ml, p < 0.01, oestriol was 495.77 nmol/l vs. 681.14 nmol/l, p < 0.01 and progesterone was 25.12 ng/ml vs. 34.52 ng/ml, p < 0.01 respectively in women with GDM and in normal pregnancy.

Adult↗
PubMed1995

[Spirometric examinations at laryngectomized patients and healthy subjects].

Spirometric studies were conducted at 40 patients, divided into on basic group (20 laryngectomized men, aged 48-77 years) and comparative group (20 healthy men, aged 20-57 years). The results obtained showed that the mean value of airways resistance was about 5-times higher than at healthy subjects. The large resistance of airways influence for considerable decreasing of the maximum ventilation volume. Tracheitis and bronchitis chronic in cause of increase resistance of airways at laryngectomized patients and it can influence for quality and understanding of vicarious voice.

Adult↗
PubMed1995

[Changes in levels of chorionic gonadotrophin (hCG) and its subunit alpha and beta in pregnancy complicated by diabetes (GDM)].

The aim of the study was estimation of endocrinological function of placenta in pregnancy complicated by GDM. The study were performed on a group 13 women with GDM and 14 women in normal pregnancy. All women with GDM were treat by diet and intensive insulinotherapy with self monitoring levels of glucose. In women with GDM level of fructosamine and HbAlc were significant higher but in normal range. In 28 and 36 week of pregnancy were determined levels of hCG, alpha hCG, beta hCG, in serum. Level of hCG in control group and in women with GDM were respectively 97.29 U/ml vs. 29.29 U/ml, p < 0.01 in 28 week of pregnancy and 77.23 U/ml vs. 37.93 U/ml, p < 0.05 in 36 week. Level of alpha hCG was lower and beta hCG was higher in group with GDM.

Case-Control Studies↗