PubMed Health⌕ Search

Biomedical subjects

J Papillon

Publications and source records attributed to J Papillon.

At least 55 records · Page 3Linked to original sources
PubMed1984

[Treatment, by 192-iridium curietherapy, of epitheliomas of the penis. Apropos of 36 cases].

Since 1975, 36 patients with squamous cell carcinoma of the penis have been treated with 192 Iridium at the Centre Léon Bérard: 17 T1 lesions, 18 T2 lesions and one T3 lesion. The tumor was less than 4 cm in diameter in 31 cases. Two patients presented with local recurrences after local excision and/or external beam irradiation with 60 Cobalt. In 32 patients followed for more than one year, the rate of local control was 84% (27/32). Five local failures were controlled by subsequent salvage surgery. The rate of severe complications is 25% (8/32): 2 urethral stenoses, 4 necroses, and 2 severe fibrosis. Conservation of a functional organ was possible in 72% of cases (23/32). Amputation was necessary in the 5 patients with lesions of more than 4 cm, because of local failure or painful complications. Ten patients had palpable inguinal lymph nodes, which were found to be involved in 4 cases. Three were controlled by combined radiotherapy and surgery. Among patients off any lymphadenopathy at the time of diagnosis, only one subsequently developed an inguinal metastasis which was controlled by radiotherapy and surgery. The disease-free survival rate was 81% at 3 years (22/27) and 75% at 5 years (12/16). Only one patient died of carcinoma. Curietherapy with 192 Iridium is very suitable treatment for cancers of the penis less than 4 cm in diameter. In most patients, the quality of life will be better than with primary surgical amputation, because sexual function is preserved.

Adult↗
PubMed1983

A new approach to the management of epidermoid carcinoma of the anal canal.

Until recently most squamous cell carcinomas of the anal canal were treated by radical surgery. Radiation therapy was only considered for palliation in case of inoperable tumors. Important progress has been made in the knowledge of the natural history of the disease and in the field of radiotherapy. Anal canal squamous cell carcinoma should not be treated any longer by the same procedure as adenocarcinoma of the lower rectum, because both these diseases differ markedly. Multimodality therapy with radiotherapy as first approach has been considered. This series of 121 cases treated since 1971 and followed more than three years suggests that three protocols based on irradiation followed or not by surgery should be used according to the extent of the disease. Of the 72 patients with resectable tumor, the five-year survival rate was 65%. Three-quarters of the patients cured had normal anal function. The rate of death from cancer was 18%. The method requires an accurate assessment of the extent of the tumor and of its pelvic lymphatic spread. Great care must be taken in planning treatment in a close cooperation between radiotherapist and surgeon.

Adult↗
PubMed1983

[Cancer of the rectum: current trends in radiotherapy in conservative treatment].

Conservative treatment of rectal cancer by intracavitary irradiation (Philips contact x-ray therapy followed or not by Iridium implant) is only applicable to tumours which are thought to have no lymphatic spread. A strict selection of cases is compulsory, especially with regard to the probability of lymph node involvement (degree of histological differentiation, degree of infiltration of the rectal wall, absence of palpable pararectal metastatic lymph nodes). After treatment, follow-up must be performed methodically. Moreover, in patients not older than 55, mesenteric and perirectal lymphadenectomy must be considered. At the Centre Léon Bérard (Lyon), 231 patients followed more than 5 years have been treated. The 5-year and 10-year survival rates are respectively 57 per cent and 74 per cent. The rate of local failure is 5.2 per cent. The rate of death from cancer at 5 and 10 years is 10 per cent. However intracavitary irradiation is only applicable in 10 to 15 per cent of rectal cancers. A new conservative approach has been worked out. It consists of preoperative external beam irradiation with Cobalt 60 (30 Gy in 12 days) followed 2 months later, according to the residual disease, either by radical surgery of Iridium implant. Applied to poor risk, patients this method can spare many of a permanent colostomy, without jeopardizing their chances of cure (27 cases, median age: 77 years).

Aged↗
PubMed1982

[Changes in the management of osteosarcomas of long bones in the Léon Bérard Center, in the last twenty years ].

From 1958 to 1977, 68 patients with long bone osteosarcoma were treated with high dose radiation (greater than 80 grays) followed by amputation when needed. The survival rate free of disease is 33% at three years (23/68) and 31% at five years (20/64). Sterilization of the limb was obtained in 72% of cases (18/25 amputation specimens). Preservation of a functional limb often proved impossible because of the frequent occurrence of trophic disorders, especially fractures, after radiotherapy. The main benefit of primary irradiation is to avoid amputations that have become useless because pulmonary metastases have arisen. Surgical excision of pulmonary metastases can lead to prolonged survival (3 out of 6 patients alive free of disease at three years). As no conclusive randomized trials are as yet available, the benefits of adjuvant therapy (chemotherapy and/or radiotherapy) are still prospective. The present policy is to use adjuvant therapy in all cases, conservative treatment for small lesions, primary amputation in children under fourteen, and primary irradiation followed by systematic amputation one year later for extensive lesions in older patients.

Adolescent↗
PubMed1982

Pseudoaneurysms of the radial artery. Importance of microsurgery. Apropos of a case.

Following a case of pseudoaneurysm of the radial artery, curiously a rare pathological entity, the authors reviewed the literature, which consists of a maximum of 50 publicized cases. The arteriographic, plethysmographic and clinical studies as well as the anatomic and physiologic findings, all seem in favor of a treatment consisting of restoration of the vascular permeability of the principal arterial axes of the forearm (radial and ulnar arterial axes). Conservative treatment may expose the affected limb to a latent or immediate functional impotency, which may be more or less serious. The authors propose a microsurgical technique, with venous interposition grafting, for a better short or long term result, and also to replace the loss of substance secondary to the resected pseudoaneurysm.

Adult↗
PubMed1979

[Endolymphatic curietherapy by lymphography with labelled lipiodol in Hodgkin's disease. A report on 408 cases (author's transl)].

The results of 373 lymphography examinations with radioactive lipiodol, conducted in 408 patients with Hodgkin's disease for diagnostic and prophylactic therapeutic purposes, during investigations carried out from 1966 to 1973 are analyzed. Tolerance was always excellent, especially from the hematological point of view. The efficacy of the procedure can be assessed by the fact that there were only 6% of failures (21/373) in glandular regions irradiated in this way for prophylactic purposes. Relapses occur more frequently in the inguino-iliac and lumbo-aortic regions than in the pelvic chains which were perfectly protected. This technique also enables both pelvic irradiation and ovarian protection in young women without any risk of failure. The procedure is particularly indicated in the following cases: supradiaphragmatic stages I and II, whatever the sex, and stage III especially in women. In sub-diaphragmatic stages I and II, it allows, in favourable cases, the ovarian function in women to remain intact by limiting external irradiation to invaded regions only.

Brachytherapy↗
PubMed1979

Clinical study of a new antikeloid agent.

An old healing drug has been assessed and found to be of clinical value in stopping the inflammatory phase of hypertrophic scars and keloids. So far, this drug has no known side effects other than occasional mild gastric intolerance and allergic reaction. Our findings are well supported in the literature. The effect of the drug on other forms of connective tissue anomalies that present an inflammatory phase is similar to that on keloids, gradually brining scars to the maturation phase. Our results on this will be published later. Madecassol has also been shown to have a preventive effect on burn and postoperative hypertrophic scars. It compares favorably in effectiveness with compression bandaging, and gives more lasting results than intralesional cortisone or radiation therapy. Finally, Madecassol has a placebo effect of 29%-well within acceptable limits.

Adult↗
PubMed1979

Immediate flap reconstruction after excision of basal cell carcinoma of the face.

The authors review 175 basal cell carcinomas of the face, treated primarily by surgery. The overall cure rate was 97%. Among these cases, 53 were treated by excision and immediate local flap reconstruction. Analysis of results in the latter group encourages the use of this method for virgin, untreated tumors provided basic rules of surgical oncology are followed. Furthermore, it has a definite advantage cosmetically over more conservative methods. If radiotherapy has been the initial treatment, however, immediate reconstruction after excision of a recurrent tumor should be contemplated reluctance.

Adult↗
PubMed1978

Pathology and correction of the stenosed nasal vestibule.

Stenosis of the nasal vestibule is a frequent cause of nasal obstruction. An anatomical study of the region will enable one to understand the physiopathology of the stenosis of the floor of the vestibule which frequently accompanies septal deformities in the premaxilla region, or which occurs after septal surgery. The correction of this circumferential stenosis has been handled satisfactorily by the use of a "Z" plasty of the floor of the vestibule. Pertinent anatomical material, schematic drawings, and clinical cases are presented.

Airway Obstruction↗