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Biomedical subjects

J Papillon

Publications and source records attributed to J Papillon.

At least 73 records · Page 4Linked to original sources
PubMed1977

[Role of the intracavitary irridiation in the curative treatment of cancer of the rectum. 170 cases].

In carcinoma of the rectum occurring in patients in whom surgery represents a high risk, the problem of local treatment is worthy of discussion in certain precisely defined cases. Intracavitary radiotherapy (contact radiotherapy, interstitial curietherapy) proved to be effective in a series of 170 patients, observed over a period of five years. The death rate due to carcinoma was less than 11 per cent. This simple, ambulatory method may be used in fragile and very elderly patients and is without danger. Surgery is still possible in the case of failure but irradiation can be used only in selected patients, in whom very close follow-up is possible.

Age Factors↗
PubMed1977

[Colonic and rectal villous tumors. Comparative study of treatment by surgery or radiotherapy. Report of 104 cases].

The authors report and analyse two series of observations of colonic and rectal villous tumours. 47 treated initially by surgical removal, 57 treated by radiotherapy, (contact radiotherapy or interstitial radium therapy). After recalling the basic pathology, they expose the results of each group of treatment and draw practical conclusions. The treatment should first be surgical, the method depending on the site and volume of the tumour; radiotherapy may be a beneficial complement when the tumour is malignant and non-invasive or when a recurrence occurs. It may exceptionally be used as a cure when the tumour has a small diameter (less than 3 cm) and is situated less than 12 cm from the anus.

Colonic Neoplasms↗
PubMed1976

[Seminoma of the ovary. Clincopathological study. The role of radiotherapy in treatment based upon a series of 31 cases (author's tranls)].

The authors collected a series of 31 cases of seminoma of the ovary over a period of 12 years. Statistical data, including the results of of lymphography, indicate that the prognosis is good, the application of strict rules in treatment being an essential condition. Certain patients with a pure seminoma of the ovary (20% of cases) die despite early and appropriate treatment. Such a fatal outcome occurs usually during the first 18 months. The prognosis in such cases may be explained in part by the degree of extension initially but the course in certain patients, fortunately rare, is quite dramatic. This can be explained neither on the basis of the histological type nor any inadequacy in therapy. Some special unknown factor must be involved. In general combined surgery and radiotherapy, adapted to the degree of extension of the disease, give the best change of definitive cure and, for the majority of patients, an entirely normal life from a feminine and maternal standpoint. This possibility of combining cure with conservation remains the basis of treatment of seminoma of the ovary in favourable cases.

Adolescent↗
PubMed1976

Pros and cons of subpectoral implantation.

At the present time, there is no universally accepted surgical technique or prosthesis for augmenting breast volume. Each surgeon has to choose with regard to shape, consistency, and volume, according to his own conviction and respecting his patient's priorities. These priorities will vary with age, profession, sexual habits, and marital and social status. In order to get the best possible results, the plastic surgeon should be adept at alternative methods and should not be restricted to one technique or one prosthesis. Patients vary considerably so our methods should be diversified. Our subpectoral implantations have given us better results than our retroglandular ones, which have been performed during the same period of time and with the same prosthesis. Consequently, retropectoral implantation is still our preferred procedure. We think that this technique, with its proper indications, deserves wider application.

Anesthesia↗
PubMed1976

[Post-operative radiotherapy of hemisphere gliomas in the adult. A statistical study of 134 cases (author's transl)].

A series of 134 adults patient with hemisphere gliomas who received post-operative radiation after surgical excision, either by conventional radiotherapy or high energy radiation, between 1966 and 1972 in the Léon-Bérard Centre. Overall survival for grade I and II astrocytomas at two years was 15/29, or 51%. Overall survival for glioblastomas was 30/91, i.e. 33% at one year, and 3/91 or 3.3% at two years. High energy radiation gave slightly superior results to conventional radiotherapy. The best results were obtained with concentrated irradiation when two series of irradiation were possible : 8/17 at one year (47%). Analysis of the literature indicates that radiotherapy, whilst remaining controversial for grades I and II astrocytomas, is recognised to be useful by all in the case of glioblastomas. The authors favour the post-operative irradiation 6,00 to 6,500 Rads, localised) for grade I and II astrocytomas with pejorative characteristics and routin- post-operative irradiation for glioblastomas over a wide field taking in almost the entire brain. This may be spread (6,000 Rads) or in a "split course" (two series of 1,800 each). The latter technique has the advantage of a simple protocol, better adapted to lesions in which the final prognosis remains very poor. Finally, the indications for radiotherapy in the case of supra-tentorial ependymomas (3 cases) and oligodendrogliomas (6 cases) are presented, together with an analysis of the complications of radiotherapy for cerebral tumours.

Adult↗
PubMed1975

Intracavitary irradiation of early rectal cancer for cure. A series of 186 cases.

If radical surgery is the only rational policy for most cases of rectal cancer, the problem of local treatment in poor surgical risk patients should be discussed in selected cases. Only limited, fairly-well-differentiated tumors, still confined to the rectal wall may have a sufficiently low probability of lymphatic spread to be amenable to local treatment. Rectal cancer, usually regarded as being slightly radiosensitive when treated by external irradiation, proves to be highly radiosensitive in the case of early cancer treated by intracavitary irradiation. This method is able to control a large amount of limited polypoid and ulcerative adenocarcinomas. In a series of 133 cases followed more than 5 years, the rate of death from cancer is only 9%, and the 5-year survival rate is 78%. As compared with local exision or electrocoagulation, intracavitary irradiation has several advantages. It does not require colostomy nor anesthesia. Contact x-ray therapy is an ambulatory treatment applicable even to elderly and fragile patients. There is no danger of fistula in the case of tumor of the anterior wall in female patients. It preserves all the chances of cure by subsequent surgery in case of failure.

Adenocarcinoma↗
PubMed1975

[Interstitial curietherapy with iridium 192 applied to small cancers of the rectum (author's transl)].

Intracavity irradiation aimed at curing cancers of the rectum mainly calls on contact radiotherapy but also on interstitial curietherapy. Iridium curietherapy has replaced Radium-therapy owing to the better homogeneousness of its' action and precise method of assay. It uses a 2 pronged fork containing 2 Iridium wires which can be very simply placed in position. It is applied on the one hand to the base of the ulcerated tumour, after abraision by contactotherapy and on the other hand as a method of prophylactic irradiation after exeresis of a malignant or degenerated polyp where the scar is badly adapted to contacto-therapy.

Iridium↗