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Biomedical subjects

J Prokopowicz

Publications and source records attributed to J Prokopowicz.

At least 19 recordsLinked to original sources
PubMed1978

Distribution of CSF (colony stimulating factor) in kidney of the mouse.

The activity of the colony stimulating factor (SCF) was measured in kidney subcellular fractions in mice. The highest activity was noted in microsomes. From other fractions, the cytosol had large amounts of CSF. On the basis of literature data, and the findings presented we suggest that the kidney is at least one of the organs of CSF biosynthesis.

Animals↗
PubMed1978

Colony stimulating factor (CSF) activity in human and murine sera.

Substances with CSF activity were studied in human and murine sera. Gel filtration of the sera on Sephadex G-200 showed that fractions with molecular weight of 14,000 and 6000 D were active in the CSF test. When mice were stimulated with endotoxin, CSF activity of both fractions was twice as high as in control animals, and CSF activity was found also in a protein peak with the molecular weight of 300,000 D. The fractions with CSF activity were sensitive to pepsin.

Animals↗
PubMed1978

Is granulopoietic activity (GA) in vivo comparable to colony stimulating factor (CSF)?

Human sera after column chromatography on Sephadex G-200 were tested for Granulopoietic Activity (GA) in vivo and Colony Stimulating Factor (CSF) in vitro. We have found that GA after chromatography is distributed in three peaks but CSF only in one peak with high activity, and evident activity in volume 135 ml. This activities are in good agreement with two peaks of GA. We assume that GA and CSF after this chromatographic procedure is free from lipoproteins inhibitors. The obtained results are briefly discussed.

Animals↗
PubMed1978

The depressing effect of tumour on bactericidal capacity of plasma and leukocytes.

Leukocyte--plasma suspensions and plasma from tumour patients have been tested in vitro against staphylococcus aureus for bactericidal capacity. Blood was collected during surgical intervention from peripheral vein and from the nearest point of vein to tumour. Second collection of peripheral blood was done 2--3 weeks later after surgery. Decrease of bactericidal activity of plasma has been found in blood collected from vein near the tumour. We can suggest that tumours release some factors disturbing the bactericidal capacity or that the tumour absorbs some factors of plasma or changes the functions of granulocytes.

Adult↗