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J Prokopowicz

Publications and source records attributed to J Prokopowicz.

47 records · Page 3Linked to original sources
PubMed1975

Peripheral and gastric fibrinolysis in patients with gastric carcinoma.

The fibrinolytic system was studied in blood-samples from gastric and peripheral veins of patients with gastric carcinoma. There was a slight decrease in plasma-euglobulin fibrinolytic activity, a rise of plasma-fibrinogen level and antithrombin VI activity, and a decrease in antiplasmin activity. The changes observed are more marked in blood-samples from gastric veins. Some therapeutical implications and the role of fibrinolytic agents in malignant diseases are briefly discussed.

Fibrin Fibrinogen Degradation Products↗
PubMedDate not supplied

Serum concentration of alpha-2-macroglobulin, alpha-1-antitrypsin and alpha-1-antichymotrypsin [correction of alpha-2-antichymotrypsin] in patients with Hodgkin's disease.

In twenty four patients diagnosed with Hodgkin's disease we have determined several antiproteases. Our findings have shown the decrease of concentration of alpha-2-macroglobulin and increase of alpha-1-proteinase inhibitor and alpha-1-antichymotrypsin. The observed changes were statistically significant p < 0.001. We did not find any correlation between the concentration of inhibitors and the clinical stage of carcinoma and histopathological data. The determination of the level of antiproteases in patients with cancer disease may be assumed to reflect partly at least the capability of anticancer mechanism in the host.

Adult↗
PubMedDate not supplied

[Human serum colony-stimulating factor in mouse bone marrow culture].

Activity of CSF was measured in human serum after chromatography on Sephadex G-200. Agar culture of bone marrow cells was done in Petri dishes with agar in Eagle'a medium containing fetal calf serum and antibiotics. This agar-medium containing mouse bone marrow cells, was allowed to gel and the dishes were incubated at 37 degrees C in a fully humidified atmosphere of 10% CO2 in air. Our data indicate that chromatography procedure allows to get CSF free from its inhibitors. All activity was localized in one peak, in the region of low molecular weight proteins.

Bone Marrow Cells↗
PubMedDate not supplied

[Colony-stimulating factor (CSF) and granulopoietic activity (GA) in various mouse organs].

The colony stimulating factor and granulopoietic activity were determined in the homogenates of mouse kidney, liver, spleen and bone marrow. The activity of CSF and GA were highest in the kidney. The homogenate of this organ was fractionated then by ultracentrifugation. The distribution of CSF and GA in subcellular fractions and homogenates may suggest that kidney cells are the source of a substance causing, both, colony stimulation and granulopoietic activity.

Animals↗