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Biomedical subjects

J Rodríguez

Publications and source records attributed to J Rodríguez.

At least 199 records · Page 11Linked to original sources
PubMed1989

[Immunosuppression with cyclosporin after orthoptic liver transplant in pigs].

The immunosuppressive effect of cyclosporine A (CsA) was studied in six pigs that underwent orthotopic liver transplant (OLT). The drug was administered i.v. in low doses (1.5-4 mg/Kg-1/12 h-1) and associated with wide spectrum antibiotics. The mean survival of the animals was 23.4 +/- 11.2 days. All animals had fever, jaundice and hypertrichosis, and the preoperative corporal weight remained constant. Liver abscesses by E. coli were common autopsy findings. Livers also presented biliary regeneration and cholestasis with a slight lymphocytic infiltration. OLT in pigs without immunosuppressive treatment causes and elevation in serum gamma-GTP, GOT, LDH, alkaline phosphatase and bilirubin. In the post-mortem findings, the livers did not present abscesses but evidenced intense atrophy with hepatocellular necrosis and abundant lymphocytic infiltration.

Animals↗
PubMed1989

[Audiologic evaluation of children by auditory responses of the brainstem].

Brainstem auditory evoked responses (BAER) were recorded in 112 children (0-14 years) submitted to us from a ORL source to evaluate the auditory function. The othologic examination and different audiologic tests (pure tone audiometry, impedance measurement, stapedial reflex) showed no definite results due to several reasons including age, uncooperativeness, low reliability, or communication impairment. The following items were evaluated: 1) Wave V threshold. 2) Latency-intensity function. 3) Interwave timing, I-V amplitude ratio, wave amputation, response to the changing rate of stimulation. Results showed the utility of BAER to: 1) Confirm the audiologic impairment: 2) determine if the anomalies are uni or bilateral; 3) quantify the intensity of hearing loss, and 4) establish a topographic diagnosis of the disease.

Auditory Threshold↗
PubMed1987

[Preventing the recurrence of febrile seizures: intermittent prevention with rectal diazepam compared with continuous treatment with sodium valproate].

Sixty nine children suffering from a first febrile seizure without evidence of neurologic disorder or associated risk factors were randomly assigned to one of three groups: no treatment; intermittent rectal diazepam; or continuous oral sodium valproate. All patients were followed for two years. Periodical controls were performed every three months in order to record febrile episodes, recurrent seizures, and treatment side affects. Rate of recurrent febrile seizures was 16% in control group, and 5.5% in diazepam group. Sodium valproate group showed no recurrences in the follow-up period. The low relapsing rate in control group suggests that prophylaxis should not be established even if it is requested by certain parental attitudes.

Administration, Rectal↗
PubMed1987

[Combination of drugs and clean intermittent catheterization in the treatment of neurogenic bladder. Effect on continence].

We report the results obtained with the association of drugs with clean intermittent catheterization (CIC) in 13 patients with neurogenic bladder due to spina bifida. The drugs used were bladder muscle relaxants (imipramine), anticholinergic (probanthine) and/or alpha-adrenergic (ephedrine). CIC alone led to acceptable continence in only 24% of cases, whereas with the addition of drugs this proportion increased to 80%. All along the treatment upper urinary tract remained stable in all patients, there were no changes in asymptomatic bacteriuria when present and collateral effects were minimal.

Child↗