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Biomedical subjects

J Rotgans

Publications and source records attributed to J Rotgans.

At least 19 recordsLinked to original sources
PubMed1991

[The effect of a chemotherapeutical amine containing toothpaste on plaque formation, gingivitis and caries in clinical and animal experiment].

"C31G" means and amine mixture, which shall be, a new "sure" substance of small toxicity and is used as an effective plaque and caries reducing chemotherapeutical substance in a tooth paste. In this study we report on: the caries reducing effect in the teeth cleaning experiment in Osborn-Mendel-rats (96 animals, 6 Groups) with C-31G-containing tooth pastes in different concentrations and also in combinations with and without fluoride. the effect of an 1% C31G-containing tooth paste on plaque formation (SLI + QHI) and gingivitis (SBI) in a clinical double blind cross over-study (section % patients, 2 groups, 2 pre-experimental OH-Plases, teeth cleaning once per day). The study results don't show the expected plaque and caries reducind effect. The results of the in vivo and in vitro experiments call for a critical examination of the substances with attention of further parameters.

Analysis of Variance↗
PubMed1990

Aluminium in tooth pastes and Alzheimer's disease.

Epidemiological studies from Norway and England suggest a relation between the frequency of Alzheimer's disease and the concentration of aluminium in the drinking water. Estimates, made in this study, show that the role of aluminium from tooth pastes may be even more important than that from the drinking water. For that reason we determined in samples of tooth pastes taken from the BENELUX market which brands contained aluminium. This appeared to be the case for about 22% of the brands which according to the manufacturers cover about 60% of the market.

Aluminum↗
PubMed1990

[The use of aluminum-containing toothpaste and its potential risk].

Epidemiological studies from Norway and England suggest that there is a relation between the frequency of Alzheimer's disease and the concentration of aluminum in the drinking water. A recent Dutch study suggests further that the role of aluminum from tooth pastes may be even more important than that from drinking water. For this reason we determined in samples from the Belgian market which tooth pastes contained aluminium oxyhydroxide as abrasive. This happened to be the case in 5 out of 27 brands. It is not know to us which part of the market these tooth pastes represent.

Aluminum Hydroxide↗
PubMed1978

[Animal experimental tests of a new filling material (Isocap)].

An experimental investigation with animals (Rhesus monkeys) concerning pulp tolerance to two premeasured dosages of calcium hydroxide cement (Reocap and Reocap-E) as well as a pre-measured dosage of filling material (Isocap) in an injection capsule was carried out (78 class V cavities). As with the negative controls, a very slight reaction, or none at all, developed in response to the two calcium hydroxide cements and the new filling material, with and without application of capping material. When five other accidentally exposed pulpae were dissected, direct capping under the corresponding preconditions (punctate exposed pulpa, longer storage period for calcium hydroxide cement) showed the characteristic formation of reparative dentin.

Animals↗