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Biomedical subjects

J Snow

Publications and source records attributed to J Snow.

At least 73 records · Page 4Linked to original sources
PubMed1981

Promising results with a new textured surface intrathoracic variable volume device for LVAS.

The smooth surface cycled chambers, both Biomer and silicone rubber, developed thick tissue capsules and exhibited persistent acute tissue reaction at the interface. The silicone rubber noncycled chambers either developed no capsule or a very thin capsule without the acute inflammation observed with the cycled side. The dacron velour surface chambers, both the cycled and noncycled, developed a thin, stable capsule, with no acute inflammation. The cycled dacron velour surface chambers have achieved almost one year with acceptable performance and are continuing at this time. These results with the textured surface compliance chambers compare favorably with the smooth surface series. Although the number of studies as yet is limited, the performance of the textured series compliance chambers shows promise for the application of the compliance chamber for use with totally implantable blood pump systems.

Animals↗
PubMed1981

Hemodynamic regulation in total artificial heart recipients.

The right and left atrial pressures (RAP and LAP), circulating blood volume (CBV) and pump output were analyzed in 17 calves implanted with a free-diaphragm-type total artificial heart. A high RAP and increased CBV were common features in these animals, while the LAP was maintained in a nearly normal range throughout the course. Some correlation was seen between RAP, CBV and pump output, which was maintained in the range of 86.6 to 130.1 ml/min/kg. In the atrial myocardium various morphological changes were observed accompanied by thickening of the cell, which was conspicuous after one month of implantation. To improve this high venous pressure problem, an automatic controller for pusher-plate-type pumps wtih a greater sensitivity was introduced. A preliminary in vivo study using this new system is also reported.

Animals↗
PubMed1980

Preventing mental retardation associated with gross obesity in the Prader-Willi syndrome.

Twenty-seven patients with Prader-Willi syndrome have been described, ten of whom did not receive comprehensive management, nine who were diagnosed and treated after becoming obese, and eight who were diagnosed in infancy and responded to early preventative treatment. Intelligence scores declined in the first two groups, but the group receiving early treatment maintained a mean IQ score 20 points higher than the other two. Even though the underlying mechanism of this disorder remains undefined, a comprehensive early intervention program appears to improve prognosis.

Adolescent↗
PubMed1979

The human dura mater valve. Fabrication methods.

We have used a glycerol-treated human dura mater valve as a valve substitute of the blood pumps for more than 3 years. In comparative studies, it was shown that the dura mater valve is more durable than the glutaraldehyde-treated bovine aortic valves, and thought to be a very attractive valve material. Fabrication methods both for rigid and flexible stents were introduced.

Acrylic Resins↗
PubMedDate not supplied

Short cervical length by ultrasound and cerclage.

OBJECTIVE: To determine whether gravidas with short cervical length on endovaginal ultrasound examination, not in preterm labor, who underwent cervical cerclage have better outcomes compared with those with no cerclage. METHODS: This is an observational study in which data were collected prospectively on women who had ultrasound endovaginal cervical length measurement and were not in preterm labor. The subgroup of women who were < or = 26 weeks' at cervical measurement was analyzed separately. Short cervix was defined as < or = 30 mm. After delivery, charts were reviewed for management and outcomes, performed at the discretion of the attending obstetrician. Two study groups were defined: those with cerclage and those with no cerclage. Predictor variables were cerclage and cervical lengths. Outcome variables were birth weight, gestational age at delivery, and neonatal outcomes. Data were analyzed using the chi-squared, Fisher's exact, and Student's t-tests, a p value of < 0.05 was considered to be significant. RESULTS: A total of 85 patients with cervical lengths of < or = 30 mm were identified; of these 43 had cerclage, and 42 did not. The latter had bedrest, tocolytics, or no intervention. Indications for cervical length measurement were similar in both groups, as were age, insurance status, cervical measurements, preterm premature rupture of membranes, and mode of delivery. The mean gestational age at delivery and birth weight in the cerclage group (34.0 +/- 5.4 weeks'; 2530 +/- 905 gm) were greater than in the no cerclage group (32.0 +/- 6.0 weeks', 2084 +/- 1085 gm, p values of < 0.04 and < 0.04, respectively). Analysis for the subgroup of women who were < or = 26 weeks at first measurement revealed similar results. The relative risk for delivering at < 30 weeks' gestation, for incrementally shorter cervices, was less in the cerclage group. CONCLUSION: Cerclage in gravidas with short cervix measured by endovaginal ultrasound, not in preterm labor, may be associated with neonates of greater gestational age and birth weight, with fewer of these parturients delivering before 30 weeks' gestation. A prospective randomized trial of treatment modalities for asymptomatic shortened cervix is needed.

Birth Weight↗