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Biomedical subjects

J Stankiewicz

Publications and source records attributed to J Stankiewicz.

At least 19 recordsLinked to original sources
PubMed1995

Latex allergy.

Over the last ten years allergy to latex has become a serious, life-threatening medical problem. Exposure to latex may result in immediate hypersensitivity reactions such as urticaria, dyspnoe, rhinitis, angioedema and anaphylactic shock in sensitized individuals. People occupationally exposed to latex--health care and rubber industry workers and children suffering from spina bifida--are the most important risk groups. Clinical manifestations, immunological mechanisms, trials for identifying latex allergens and laboratory testing are reviewed here. Moreover, the authors present two cases of latex allergy diagnosed with the use of a nasal challenge test. 0.0005% latex solution (Stallergen) and latex extract prepared at the Clinic were used. Nasal washings were performed before, 30 minutes, 3 and 24 hours after provocation. The test evaluation was based on changes in the number and type of cells present in the washings. As there is no laboratory test to be used in latex allergy diagnosis approved by the Food and Drug Administration (FDA) the nasal provocation test seems to be worthy of further investigation. Ways of reducing of the allergenicity of latex products and preventing hypersensitivity reactions are also presented.

Adult↗
PubMed1993

[Effect of environmental factors on prevalence of epileptic seizures].

A decreased convulsant threshold is found in 10% of human population. This population is at higher risk of epileptic seizure in the case of exposure to harmful factors at working place or outside it. The following harmful factors should be taken into consideration: 1. traumas, 2. physical agents (high temperature, electrocution, specific sensory stimuli), 3. toxic agents (organic solvents, organophosphorus compounds, lead, alcohol, some drugs and narcotics). Therefore, detection of the decreased convulsant threshold and gathering knowledge about potential epileptogenic factors at working places and in community environment should become one of the goals for medical personnel dealing with occupational problems. The authors recommend to perform pre-employment EEG examination whenever an increased risk of epileptic seizure is suspected in a given person following an interview and information on working conditions. It is also recommended to supplement work safety and hygiene instructions.

Environmental Exposure↗
PubMed1992

Impairment of peripheral nervous system in patients with non-Hodgkin's lymphomas treated with CBVPM/AVBP and CHOP schedules.

Clinical examination and conduction velocity measurements in peripheral nerves have been done on 56 patients with non-Hodgkin's lymphomas of high malignancy (NHL). It is suggested that: the evaluation of the influence of chemotherapy on peripheral nervous system (PNS) is possible by means of systematic neurological and electroneurographic studies; electroneurographic assessment is most important in the diagnosis of early subclinical stages of peripheral neuropathy; toxic influence of CBVPM/AVBP protocol on PNS is greater than CHOP schedule; impairment of PNS due to chemotherapy is reversible in patients during complete remission (CR).

Adolescent↗
PubMed1991

The endoscopic approach to the lateral accessory sphenoid sinus.

In summary, an interesting case of an accessory parasphenoid sinus mucocele in a 10-year-old girl is reported. By choosing an endoscopic approach, hearing and balance were preserved, and an external sinus or neurosurgical procedure avoided. The surgery was done on an outpatient basis, with minimal postoperative discomfort and no complications. The mucocele was adequately drained and there has been no recurrence over the following 12 months.

Child↗
PubMed1988

[Electromyographic estimation of functional state of the mouth slit's muscles after the lip reconstruction by means of various methods].

The authors present the results of functional state examination of the orbicular muscle of the mouth in 28 patients operated by means of Abbe's and Karapandzicz's method because of vermilion border's carcinoma. It has been found that no features of neurogenic damage of the muscle were present in the group of patients operated by means of Karapandzicz's method and the return to its proper function was more frequent. It points out that Karapandzicz's method is less invasive in comparison with Abbe's method.

Electromyography↗
PubMed1985

Intubation-related tracheal stenosis in very-low-birth-weight infants. Diagnosis and treatment.

Five infants who developed intubation-related tracheal stenosis were treated surgically with an anterior cricoid split instead of a tracheostomy. This surgery allowed early extubation and discharge of these patients who, on follow-up, have had adequate phonation and no further respiratory compromise. We suggest that this surgery be considered for all infants who develop intubation-related tracheal stenosis.

Cricoid Cartilage↗
PubMed1984

Mucocutaneous lymph node syndrome.

A 3-year-old child presented with a short clinical history of fever and diffuse cervical lymphadenopathy, and the diagnosis of mucocutaneous lymph node syndrome was reached. We include a discussion of the case history and a brief review of this disorder.

Child, Preschool↗
PubMed1981

Studies on derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid. IV. Addition reactions of thioglycolic acid to 2-N-aralkylidene derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid.

In the course of studies on compounds with expected antiinflammatory and immunosuppressive activity a series of new derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid have been synthesized. Several new and unexpected details of the chemical properties of these compounds were revealed. The chemical structure of the new compounds was confirmed by degradation and identification of the decomposition products and by spectral analysis.

Amino Acids↗
PubMed1981

Studies on derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid. V. Syntheses of 2-N-aralkylidene and 2-N-aralkyl derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid.

A number of new N-aralkylidene and N-aralkyl derivatives of amides and hydrazides of 2-amino-4-p-chlorophenylthiazole-5-acetic acid (III-XXIX) have been synthesized. These compounds were obtained in two various ways depending on the character of substituents in the carboxyl group. The chemical structure of the newly obtained compounds was determined on the basis of the data of elementary and spectral analyses.

Amino Acids↗
PubMed1981

Studies on derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid. VI. Syntheses and properties of 2-N-aralkyl-alpha-sulphoderivatives of tert-amides of 2-amino-4-p-chlorophenylthiazole-5-acetic acid.

In the course of the studies on compounds with expected antiinflammatory and immunosuppressive activity several new tert-amides derivatives of 2-N-aralkylamino-alpha-sulpho-2-amino-4-p-chlorophenylthiazole-5-acetic acid were synthesized. Some of the previously described Schiff bases reacted with aqueous alcoholic solution of sodium bisulphite and as a result several (III-VIII) alpha-sulphoderivatives were obtained. The course of the reactions was studied and the structure of the new compounds was confirmed.

Amides↗
PubMed1979

Studies on the derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid. I. Syntheses and pharmacological analysis of acylderivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid.

A number of new acyl and imidoderivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid (II) and its methyl ester (VII) were synthesized. Methyl ester VII heated in benzene solution with acid anhydrides was transformed into adequate acyl derivatives (VIII, IX, X, XIII, XVI). Some of them (X, XIII, XVII) by heating with acetic anhydride underwent cyclization and were transformed into the imido derivatives (XI, XIV, XVIII). Compounds XI, XIV and XVI heated with diluted aqueous solution of sodium hydroxide underwent selective hydrolysis giving the respective dicarboxylic acids XII, XV, XVII. Pharmacological analysis revealed that some of the synthesized preparations exert an anti-inflammatory effect and allow to draw limited relations between chemical structure and pharmacological activity in this group of compounds.

Analgesia↗
PubMed1979

Studies on the derivatives of thiazole acetic acid. II. Syntheses and pharmacological analysis of 2-N-aralkylidene and 2-N-aralkyl derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid.

A number of 2-N-aralkylidene, 2-N-aralkyl and 2-N-aralkyl-alpha-sulphoderivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid (I, R = H) and its methyl ester (I, R = CH3) were synthesized. As a result of condensation of methyl ester I with various aromatic aldehydes in boiling benzene solution, the Schiff-bases (anils) II--VIII were obtained. After reduction with NaBH4 compounds II--VIII were transformed into adequate amino esters IX--XV. Esters IX--XV heated with diluted aqueous solution of sodium hydroxide underwent selective hydrolysis giving the respective amino acids XVI--XXII. Some of Schiff bases (II, III, V, VII, VIII) reacted with aqueous alcoholic solution of sodium bisulphite after its several (XXIII--XXVII). alpha-sulphoderivatives had been obtained. Several tests were performed in order to detect the anti-inflammatory and immunosuppressive activity of the compounds. The pharmacological analysis allowed us to draw conclusions concerning the relationship between chemical structure and biological activity in this group of compounds. The most efficacious immunosuppressive and anti-inflammatory activity exhibited 2-aralkyl-alpha-sulphoderivatives.

Adjuvants, Immunologic↗
PubMed1979

[2 cases of ocular myopathy].

On the basis of two cases of progressive external ophthalmoplegia the authors discuss the clinical manifestations of this disease and call attention to diagnostic difficulties.

Adult↗