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J Stasiewicz

Publications and source records attributed to J Stasiewicz.

87 records · Page 5Linked to original sources

[Anatomic changes in the biliary tract and pancreas in patients with diabetes mellitus diagnosed by endoscopic retrograde cholangiopancreatography].

Structural changes in both biliary tract and pancreas have been assessed with endoscopic retrograde cholangiopancreatography in 100 diabetic patients divided into subgroups depending on the type of diabetes mellitus, i.e. type I, type II and III-pancreatic. Control group included 100 randomly selected patients without diabetes mellitus in whom endoscopic retrograde cholangiopancreatography has been performed for various indications. Structural changes in the biliary tract and pancreas have been more frequent in diabetic patients than in the control group (47 and 75% vs 32 and 30%, respectively). Cholelithiasis has been noted in 27.8% of patients with type II diabetes mellitus and in 11.3% of patients with type I diabetes mellitus; obesity has been found in 57 and 12% of patients, respectively. Other biliary tract disorders, mainly in the form of segmental stenosis or dilatation of the common bile duct, have been more frequent in patients with type II diabetes mellitus. Pancreatic disorders, assessed with the aid of Cambridge classification, have been noted in all patients with pancreatic diabetes and in 80.7% of patients with diabetes mellitus type I. Incidence of so-called doubtful and mild disorders has been more frequent (22.2 and 24.1%, respectively) in patients with diabetes mellitus type II whereas "moderate" and "severe" disorders have been significantly less frequent (7.4 and 1.9% of patients). The results indicate, that endoscopic retrograde cholangiopancreatography is useful in the assessment of bile ducts structure and pancreatic exocrine activity in diabetic patients in whom disorders are more frequent.

Adult↗

Endoscopic retrograde pancreatography in elderly patients.

We studied two hundred patients aged 65-88 years who underwent endoscopic retrograde pancreatography (ERP); the control group included 200 patients aged 35-55 years. A normal pancreatogram was found in 51.6% of the geriatric patients and in 59.0% of the middle-aged patients. Pancreatic carcinoma and chronic pancreatitis with "Moderate" changes (according to the Cambridge classification) were significantly more frequent in the group of elderly patients. In the geriatric patients without pancreatic changes in the ERP, the main pancreatic duct (in the head, body and tail of the pancreas) was significantly wider than that in the corresponding group of middle-aged patients. We suppose that age-dependent changes in the pancreas must be taken into consideration during diagnostic procedure in elderly patients.

Adult↗

[Comparison of the results of the treatment with pirenzepine combined with cimetidine and sucralfate of stomach ulcer resistant to cimetidine].

Increased inhibition of gastric acid release through simultaneous blockade of H2-receptors and muscarine-receptors or administration of gastroprotective agent is theoretically justified in patients with peptic ulcer unresponsive to cimetidine. The study involved 70 patients with peptic ulcer previously treated with cimetidine in daily dose 1000 mg for 6 weeks without an effect. Patients were divided into two groups: group 1 treated with cimetidine plus pirenzepine, and group 2 given sucralfate in daily dose 4.0 g. Pirenzepine to patients of group 1 was given in a single dose of 50 mg before bedtime. Both groups were comparable in age, sex, disease onset, smoking, gastric acid secretion, and ulcer size. Healing was evaluated with endoscopic technique following 2 and weeks of therapy. Ulceration healed up within 2 weeks in 40% of patients treated with cimetidine combined with pirenzepine and in 31.4% patients treated with sucralfate. After 4 weeks, healing of ulceration was 71.4% and 68.6%, respectively. Large ulcers (over 1 cm in diameter) and previous partial gastrectomy did not affect healing rate. The obtained results suggest that administered therapies enable recovery in over 2/3 of patients with peptic ulcer unresponsive to a 6-week therapy with cimetidine alone.

Cimetidine↗

Motor interaction between cimetidine and cholecystokinin-related peptides in the gall bladder.

In vitro cimetidine (10(-5) g/ml), an antagonist of H2-histamine receptors, caused an augmentation of the contractile effects of histamine (10(-8) - 10(-6) g/m) and caerulein (10(-10) - 10(-8) g/ml) on isolated guinea-pig gall bladder. Also in vivo pretreatment of anesthetized dogs with cimetidine (3 mg/kg) induced an increase of the motor response of the gall bladder to Boots pancreozymin (0.5-5.0 CHR U/kg). These results confirm the existence of relaxing effect of H2 -- receptors in musculature of the gall bladder which can modify the contractile action of cholecystokinin-related peptides.

Animals↗