PubMed Health⌕ Search

Biomedical subjects

J Stríbrná

Publications and source records attributed to J Stríbrná.

At least 73 records · Page 4Linked to original sources
PubMed1982

The effect of renal revascularization on decreased glomerular filtration rate in patients with renovascular hypertension.

The effect of revascularization on decreased glomerular filtration rate (GFR) was studied in 18 patients with renovascular hypertension (RVH) for a period of 5 to 74 months after operation. Renal artery stenosis (SRA) was present unilaterally in 3 patients, bilaterally in 13 patients, and in two patients with one kidney. Following surgical correction, the GFR increased or normalized in 6 patients, decreased in 2, and did not change in 10 patients. The blood pressure of almost 90% of the operated patients normalized or improved. The results support the assumption that severe hypertension is indicated for surgery, irrespective of the magnitude of GFR decrease. Revascularization effected a reversal of renal insufficiency only in a third of the patients.

Adult↗
PubMed1981

Peripheral plasma renin activity (PRA) in recipients with allograft artery stenosis; its diagnostic value in acute stage hypertension.

Peripheral PRA was examined in 11 patients with graft artery stenosis after the onset and throughout the course of hypertension. In the acute stage PRA was elevated in 9 patients and decreased to normal in the later stage of hypertension in all but 1 patient with malignant hypertension. The findings suggest that the determination of peripheral PRA is helpful in diagnosing graft artery stenosis only in the acute stage of hypertension, but it has no unequivocal value to the prognosis of hypertension or indication for operation.

Adult↗
PubMed1981

Response of peripheral plasma renin activity (PRA) to furosemide stimulation; reduction of the renal parenchyma as a limiting factor.

The authors examined 34 patients with arterial hypertension, whose glomerular filtration rate ranged from normal to renal failure. The peripheral plasma renin activity (PRA) values were determined before and 30 and 90 min after injecting furosemide. In 17 patients with chronic renal failure treated by haemodialysis and with arterial hypertension, PRA was likewise determined before and after injecting furosemide. In 18 patients, including 13 from this latter group, PRA was determined before and after dialysis. It was found that: 1) In the group of non-dialysed patients, mean PRA rose significantly after the injection of furosemide. In dialysed patients it was not affected either by furosemide or by dialysis. 2) In non-dialysed patients, the ability of PRA to be stimulated by furosemide fell together with inulin clearance (Cin) in a significant hyperbolic relationship. 3) PRA changes in dialysed patients were indistinct and variable. A significant direct correlation was found between the absolute change in PRA after furosemide and after dialysis. These findings show that the degree of damage to the renal parenchyma must be taken into account when evaluating the response of PRA to furosemide stimulation.

Adult↗
PubMed1981

Acute effect of furosemide on Na and K excretion fractions in patients with allotransplanted kidney.

The acute effect of 20 mg i. v. furosemide on the excretion fraction (EF) of osm, Na, K, and urea was investigated in groups of 32 patients with chronic renal disease and 20 with renal allograft. In renal patients furosemide elicited comparably high increment (delta) of EF osm, Na, and K in both the stage of renal insufficiency and at normal Cin. In transplant patients, the delta EFosm increased in linear relationship to increasing Cin. The different response seems to be attributable to the significance of the correlation of delta EFk to delta EFosm, resp., delta EFNa. The results indicate that in transplant patients the acute effect of furosemide on tubular transport of solutes increases with increasing GFR. This finding could be explained by the influence on potassium excretion.

Adult↗
PubMed1981

Renal artery stenosis of the transplanted kidney. Diagnosis and therapy of the hypertension.

Indications for the angiography, probability, of the diagnosis of renovascular hypertension and results of the surgical and medical treatment were considered in 16 patients with renal artery stenosis of the transplanted kidney. The evaluation shows that an increase in the blood pressure in patients with good, stabilized graft function is the most essential clinical symptom of the stenosis. An increase in the peripheral plasma renin activity is of diagnostic value only in the acute phase of the hypertension. The examination of the plasma renin activity in renal veins is valuable when deciding the indication for surgical therapy of hypertension. The results of surgical interventions in two patients with renal artery stenosis in the anastomosis supported the diagnosis of the renovascular hypertension and indicated that reason of the increased blood pressure and deterioration of the graft function need not be the same. In the course of the medical therapy 14 patients were followed--out of them ten patients for 1 to 4 years. The results showed the medical therapy had a good prognosis in these risk patients. Thus, the reconstruction of the artery is indicated only in the case of serious stenosis threatening the loss of graft function and in the case of the accelerated hypertension.

Adult↗
PubMed1981

Determination of plasma renin activity in renal veins of kidney graft recipients.

Renal vein plasma renin activity (PRA) was examined in 10 cadaver kidney recipients with graft artery stenosis detected by angiography in 8 of them. A significantly higher PRA in the graft versus the autologous renal veins occurred only in 1 patient: 4 patients showed significantly higher PRA values in autologous renal veins and 4 showed only insignificant differences. In 1 patient PRA could be determined only in the graft vein. Bilateral autologous nephrectomy was performed in 2 patients. The effect of surgery on hypertension agreed with the results of PRA determination. Renal Vein PRA is a valuable criterion in the indication for surgery. In some patients its determination does not help to decide whether the causative factor of hypertension is the graft or autologous kidneys.

Adult↗
PubMed1980

Importance of hypertrophy of resistance vessels in humans in different stages of hypertension.

One of the causes of fixation of elevated blood pressure are structural changes in the arterial wall manifested at first by hypertrophy of the smooth muscle and later by proliferation of connective tissue. These changes can be evaluated in humans from the degree of vasodilatation during reactive hyperaemia. We found that the inability of adequate vasodilatation is typical for all types of hypertension, i.e. essential hypertension in young and elderly subjects stage I and II, and vasorenal hypertension. On the other hand, in patients with borderline hypertension structural changes do not develop. The inability of adequate vasodilatation in patients with hypertension persists also during a short-term reduction of the blood pressure to normal values as a result of therapy. In patients operated successfully on account of vasorenal hypertension the normal vasodilatation capacity is regained after one year of normalization of blood pressure.

Adult↗