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Biomedical subjects

J Stratigos

Publications and source records attributed to J Stratigos.

At least 55 records · Page 3Linked to original sources
PubMed1986

Bovine ringworm. An outbreak caused by Trichophyton mentagrophytes var. granulare in Greece.

Seven cattle barns were investigated during the years 1976 through 1977. Six of these barns located in central Euboea have been characterized as "suspect" barns because one or more persons working in these barns had been infected by dermatomycosis. The seventh barn serving as control was located on the opposite side of the Boeotic coast. A total of 60 "suspected as infected" animals were isolated from all these barns. Twenty-one of them (35%) gave positive cultures for dermatophytes in Sabouraud medium. Of the 113 "healthy" animals that were examined, 28 (24.8%) gave positive cultures. The only pathogenic strain of dermatophyte that was isolated was the Trichophyton mentagrophytes var. granulare.

Animal Husbandry↗
PubMed1986

Reduction of cell mediated immunity in patients with genital warts of long duration.

Cell mediated immunity was studied by a leucocyte migration inhibition assay and by tuberculin and dinitrochlorobenzene skin tests in 30 patients with recurrent genital warts and in 34 healthy people (with no history of genital warts) who served as controls. Migration inhibition was significantly less in patients suffering from recurrences for more than one year than in controls (p less than 0.001). Dinitrochlorobenzene and tuberculin sensitivity were also found to be impaired in those with infection of long duration (p less than 0.001).

Adolescent↗
PubMed1985

Human lymphocyte antigens A, B, and C in Greek patients with psoriasis: relation to age and clinical expression of the disease.

The frequencies of human lymphocyte antigens (HLAs) A, B, and Cw6 were studied in a group of 212 Greek patients with psoriasis and 202 control subjects. An increased frequency of B13, B16, and Cw6 antigens and a low frequency of B14 were noted in the group of all patients. However, there were striking differences in HLA phenotypes according to the age at onset of the disease. Early onset (less than 25 years of age) was associated with a high frequency of A1, B17, B37, and Cw6 antigens, whereas patients with late onset (greater than 25 years of age) had a significantly lower incidence of A1, B17, and Cw6, which did not differ from that of the control subjects. Patients with onset of the disease greater than 60 years of age had, in addition, an increased frequency of B16. Psoriatic erythroderma was characterized by an increase of Aw19 and a higher frequency of B13 than in the total group of patients with psoriasis. In patients with a familial incidence of the disease, there was no significant association with any particular HLA.

Adolescent↗
PubMed1985

Some further features for differential diagnosis between squamous cell carcinomas and basal cell epitheliomas.

Two further methods for the characterization of epidermal skin tumors are described: the antinuclear antibody (ANA) immunofluorescent test, which consists of indirect immunofluorescence with known high titer sera containing homogenous ANAs on epidermal skin tumors, and the ammoniacal-silver cytochemical method, which specifically stains nuclear histones. Squamous cell carcinomas (SCCs), basal cell epitheliomas (BCEs) as well as control specimens from normal skin and benign epidermal hyperplasias were studied. The ANA immunofluorescent test was positive for most SCCs, mixed SCC and basal cell carcinomas and metatypical BCEs. The ammoniacal-silver method gave a characteristic staining pattern shared among SCCs, mixed carcinomas and metatypical BCEs. BCEs, besides metatypical ones, were always negative by the ANA immunofluorescent test and the same applied for the control specimens. The ammoniacal-silver method gave a characteristic staining pattern for BCEs and control sections quite different from the staining pattern of the more aggressive forms of epidermal tumors. The two methods usually yielded parallel results.

Antibodies, Antinuclear↗
PubMed1985

The dermal cellular infiltrate and cell-mediated immunity in skin carcinomas.

The cell-mediated immunity in nonmelanotic skin cancer was studied in 115 patients. The diagnosis and type of skin cancer was histologically evaluated. The T cell levels and leukocyte migration test in preoperative patients with squamous cell skin carcinoma (SCSC) and metatypical basal cell epithelioma were significantly lower than in the noncancer control population. The immunocompetence was not impaired in patients with basal cell epithelioma (BCE) and even in those with BCE that showed deep invasiveness and paucity of lymphocytic infiltration. There was a direct correlation between cell-mediated immunity and the lymphocytic infiltration and differentiation of the cells in SCSC.

Adult↗
PubMed1985

Blood lymphocyte subpopulations studied with monoclonal antibodies in aleukaemic stages of mycosis fungoides.

Peripheral blood lymphocytes from 21 patients with aleukaemic stages of mycosis fungoides were studied with monoclonal T cell antibodies. Patients with erythematous eruptions or infiltrated plaques (group I) had a higher percentage of OKT4+ cells than patients with a tumorous stage (group II) or normal subjects (p = 0.05). OKT8+ cells were decreased in group I patients whereas in group II they were usually normal or increased (p less than 0.02). These data indicate that with advancing stage of the disease a different pattern of imbalance of T-cell subsets is being established.

Adult↗
PubMed1985

Hostile personality characteristics, dysthymic states and neurotic symptoms in urticaria, psoriasis and alopecia.

Three experimental groups of patients with urticaria, psoriasis and alopecia were compared for hostile personality characteristics, states of anxiety and depression, neurotic syndromes and stress with a control group of patients with other skin diseases. The patients from each experimental group were found to be less dominant, more intropunitive, more extrapunitive and more neurotic than the control group. The following neurotic syndromes differentiated the experimental groups: non-specific anxiety states in urticaria patients; neurotic depression in the patients with alopecia, and a variety of neurotic syndromes in the psoriasis patients. All experimental groups scored significantly higher than the controls in stress experienced during the year preceding the onset or the exacerbation of the illness.

Adult↗
PubMed1984

Histocompatibility antigens HLA-A, -B, -DR in Greek patients with Kaposi's sarcoma.

Thirty-two Greek patients with histologically documented Kaposi's sarcoma, aged 46 to 82 years, were typed for HLA-A, B and DR antigens. None of them was homosexual and they had not been subjected to any immunosuppressive therapy. The study revealed a significant increase of HLA-DR5 (53.1% vs. 21.4%, R.R. 4.1) and a decreased frequency of HLA-DR1 (3.3% vs. 16.6%, R.R. 0.16). An increased frequency of HLA-B18 was also noted (43.7% vs. 20.7% R.R. 2.96). These results indicate that the same positive association with HLA-DR5 antigen is observed in Greek patients as in other patients of Mediterranean origin and support the view that HLA linked factor(s) may have a role in the development of the disease.

Aged↗
PubMed1984

Ophthalmological manifestations in patients with psoriasis.

101 patients suffering from psoriasis have been examined ophthalmologically, in order to determine the incidence of the eye symptoms. The most important finding was iridocyclitis (uveitis) which was present in 3 out of 7 patients suffering from psoriatic arthritis.

Adult↗
PubMed1983

Sweat gland disturbances in granuloma annulare and necrobiosis lipoidica.

We studied sweat gland distribution, density and activity in thirteen cases of granuloma annulare and ten cases of necrobiosis lipoidica, using a combination of the plastic impression and starch-iodine methods. The pattern of sweat gland disturbance in the two diseases was entirely different. In necrobiosis lipoidica an intense and uniform hypohidrosis was detected throughout the lesion, whereas in granuloma annulare the disturbance followed the morphology of the lesion (the papular border showed complete anhidrosis, whereas the flat central part of the lesion showed only moderate hypohidrosis or normal sweating). The method assigns numerical values to the 'relative density' and the 'relative activity' of the functioning sweat glands compared with normal skin, thus permitting statistical evaluation of the results.

Adolescent↗
PubMed1983

In situ identification of mononuclear cells in lichen planus.

In this study, the in situ immunological typing of cell populations in lichen planus was attempted. T lymphocytes and suppressor/cytotoxic subsets, B lymphocytes, macrophages, immunocytes and Langerhans' cells were studied by one or more technical parameters and semiquantitative assessment of T cell populations were carried out. A critical evaluation of assays for T cell characterization was also attempted. T cells were found predominant in lichen planus infiltrate but macrophages were also many. Langerhans' cells were increased in the epidermis compared to normal skin and contact dermatitis.

Antibodies, Monoclonal↗
PubMed1982

Sweat gland function in dermatophytosis.

In 54 cases of dermatophytosis, sweat gland disturbances and their possible mechanisms were studied. The basic perspiratory malfunction was intense hypohidrosis, with some hyperhidrotic phenomena being observed at particular points of the exanthem (margin and disc) in a few cases. It is worth noting that in 51.85% of the cases, hypohidrotic phenomena were also observed in areas of normal skin adjacent to the lesions. One of the most important forms of perspiratory disturbances was the closure of sweat ducts at the keratin level. The inflammatory process in the dermis may also affect gland function. Finally, there is a discussion of the significance of perspiratory disturbances in relation to special aspects of the disease.

Adult↗
PubMed1982

Bullous pemphigoid, cicatricial pemphigoid, and pemphigus vulgaris. A comparative clinical survey of 278 cases.

The clinical features of bullous pemphigoid (BP), cicatricial pemphigoid (CP), and pemphigus vulgaris (PV), based upon examination of 278 patients during the years 1972 through 1981, are recorded. Data in relation to age, sex, site of onset, duration of the disease at the site of onset, distribution of oral, skin, and extracutaneous lesions, and time of final diagnosis are analyzed for each disease separately, and a detailed discussion in comparison with previous reports follows. Comparative evaluation of all the clinical data permitted identification of similarities and differences in the clinical manifestations within this disease group and provided an opportunity to increase our knowledge and understanding of the overall clinical behavior of these bullous diseases. Greater awareness of these entities, which very often involve the oral mucosa, in correlation with careful clinical observation is of particular importance and leads to early diagnosis and improved treatment.

Adolescent↗
PubMed1982

Anhidrotic ectodermal dysplasia. Therapeutic attempts.

In 2 patients with anhidrotic ectodermal dysplasia, we were able to show that the hypoplastic eccrine glandular elements may give rise to normal eccrine glands both anatomically and functionally, after repeated local application of acetylcholine. The perspectives of our findings for the therapeutic management of the anhidrotic ectodermal dysplasia are discussed and special attention is paid to the genetic background of the defect as well as the possible mode of action of acetylcholine.

Acetylcholine↗